Methylarginine (original) (raw)

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dbo:abstract La N-méthyl-L-arginine est un dérivé méthylé de l'arginine, un acide aminé protéinogène. On trouve naturellement des résidus de méthylarginine dans les protéines méthylées, notamment dans les histones. Il s'agit d'un inhibiteur de l'oxyde nitrique synthase et elle est utilisée pour en étudier les fonctions physiologiques. Elle présente un effet inhibiteur sur la vasodilatation, plus faible chez les patients hypertendus que chez les personnes saines. Cet effet décline avec l'âge mais peut être partiellement restauré avec la vitamine C chez les patients les moins âgés. (fr) N-Methylarginine is an inhibitor of nitric oxide synthase. Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide. The inhibiting effect of N-methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction. The inhibiting effect of N-methylarginine on vasodilation declines progressively with age, but has been restored with vitamin C in the oldest subjects. An example of N-methylarginine soluble form, that has been used in a number of clinical research trials can be found here. (en) N-Metilarginina é um da óxido nítrico sintase. Quimicamente, é um derivado metil do aminoácido arginina. É usado como uma ferramenta bioquímica no estudo do papel fisiológico do óxido nítrico. (pt)
dbo:alternativeName 2-Amino-5-[(N’-methylcarbamimidoyl)amino]pentanoic acid; N-Monomethylarginine; omega-N-Methylarginine; Tilarginine; Targinine (en)
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dbp:imagecaption -Methylarginine (en)
dbp:imagefile L-Monomethylarginine.svg (en)
dbp:imagename Stereo, skeletal formula of methylarginine (en)
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dbp:verifiedfields changed (en)
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dct:subject dbc:Amino_acids dbc:Guanidines
gold:hypernym dbr:Inhibitor
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rdfs:comment La N-méthyl-L-arginine est un dérivé méthylé de l'arginine, un acide aminé protéinogène. On trouve naturellement des résidus de méthylarginine dans les protéines méthylées, notamment dans les histones. Il s'agit d'un inhibiteur de l'oxyde nitrique synthase et elle est utilisée pour en étudier les fonctions physiologiques. Elle présente un effet inhibiteur sur la vasodilatation, plus faible chez les patients hypertendus que chez les personnes saines. Cet effet décline avec l'âge mais peut être partiellement restauré avec la vitamine C chez les patients les moins âgés. (fr) N-Metilarginina é um da óxido nítrico sintase. Quimicamente, é um derivado metil do aminoácido arginina. É usado como uma ferramenta bioquímica no estudo do papel fisiológico do óxido nítrico. (pt) N-Methylarginine is an inhibitor of nitric oxide synthase. Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide. The inhibiting effect of N-methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction. The inhibiting effect of N-methylarginine on vasodilation declines progressively with age, but has been restored with vitamin C in the oldest subjects. (en)
rdfs:label N-Méthylarginine (fr) Methylarginine (en) N-Metilarginina (pt)
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