| dbo:abstract |
N-Formylmethionyl-leucyl-phenylalanine (fMLF, fMLP or N-formyl-met-leu-phe) is an N-formylated tripeptide and sometimes simply referred to as chemotactic peptide is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator. fMLF is the prototypical representative of the N-formylated oligopeptide family of chemotactic factors. These oligopeptides are known to be, or mimic the actions of, the N-formyl oligopeptides that are (a) released by tissue bacteria, (b) attract and activate circulating blood leukocytes by binding to specific G protein coupled receptors on these cells, and (c) thereby direct the inflammatory response to sites of bacterial invasion. fMLF is involved in the innate immunity mechanism for host defense against pathogens. fMLF led to the first discovery of a leukocyte receptor for a chemotactic factor, defined three different types of fMLF receptors that have complementary and/or opposing effects on inflammatory responses as well as many other activities, and helped define the stimulus-response coupling mechanisms by which diverse chemotactic factors and their G protein coupled receptors induce cellular function. (en) |
| dbo:alternativeName |
Chemotactic peptide (en) F-Met-Leu-Phe (en) fMLP (en) (L)-Phenylalanine, N-(N-(N-formyl-(L)-methionyl)-(L)-leucyl)- (en) |
| dbo:iupacName |
(2S)-2-{(2S)-2-[(2S)-2-Formamido-4-(methylsulfanyl)butanamido]-4-methylpentanamido}-3-phenylpropanoic acid (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Chemotactic_peptide.png?width=300 |
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dbr:Antimicrobial dbr:Hydrogen_peroxide dbr:Degranulation dbr:Innate_immune_system dbr:Innate_immunity dbr:Oligopeptide dbr:Phagocytosis dbr:N-Formylmethionine dbr:Leukocytes dbr:Cloning dbr:Élie_Metchnikoff dbr:Pathogen dbr:Phagocyte dbc:Formamides dbr:Transcription_(genetics) dbr:Cytotoxic dbr:Gram_positive_bacteria dbr:Amine dbr:Dalton_(unit) dbr:Escherichia_coli dbr:Eukaryote dbr:Carboxylic_acid dbr:Formyl_peptide_receptor_1 dbr:Formyl_peptide_receptor_2 dbr:Formyl_peptide_receptor_3 dbr:Formylation dbr:Tripeptide dbc:Tripeptides dbr:Superoxide dbr:Find-me_signals dbr:Macrophage dbr:Reactive_oxygen_species dbr:Molecular_weight dbr:Neutrophils dbr:G_protein_coupled_receptor dbr:Gram_negative_bacteria dbr:Polymorphonuclear_leukocyte dbr:Chemotactic_factor |
| dbp:imagefile |
Chemotactic peptide.png (en) |
| dbp:imagesize |
200 (xsd:integer) |
| dbp:name |
N-Formylmethionine leucyl-phenylalanine (en) |
| dbp:othernames |
Chemotactic peptide (en) (L)-Phenylalanine, N-- (en) F-Met-Leu-Phe (en) fMLP (en) |
| dbp:pin |
-2 (xsd:integer) |
| dbp:verifiedrevid |
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| dcterms:subject |
dbc:Formamides dbc:Tripeptides |
| gold:hypernym |
dbr:Tripeptide |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Abstraction100002137 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Peptide114743046 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:WikicatPeptides umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
N-Formylmethionyl-leucyl-phenylalanine (fMLF, fMLP or N-formyl-met-leu-phe) is an N-formylated tripeptide and sometimes simply referred to as chemotactic peptide is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator. (en) |
| rdfs:label |
N-Formylmethionine-leucyl-phenylalanine (en) |
| owl:sameAs |
freebase:N-Formylmethionine-leucyl-phenylalanine freebase:N-Formylmethionine-leucyl-phenylalanine yago-res:N-Formylmethionine-leucyl-phenylalanine wikidata:N-Formylmethionine-leucyl-phenylalanine http://azb.dbpedia.org/resource/ان-فرمیل_متیونین_لئوسیل-فنیل_الانین dbpedia-fa:N-Formylmethionine-leucyl-phenylalanine dbpedia-sh:N-Formylmethionine-leucyl-phenylalanine dbpedia-sr:N-Formylmethionine-leucyl-phenylalanine https://global.dbpedia.org/id/4iBcU |
| prov:wasDerivedFrom |
wikipedia-en:N-Formylmethionine-leucyl-phenylalanine?oldid=1096107260&ns=0 |
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wiki-commons:Special:FilePath/Chemotactic_peptide.png |
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wikipedia-en:N-Formylmethionine-leucyl-phenylalanine |
| foaf:name |
N-Formylmethionine leucyl-phenylalanine (en) |
| is dbo:wikiPageRedirects of |
dbr:C21H31N3O5S dbr:FMLF dbr:FMLP dbr:Chemotactic_peptide dbr:N-Formylmethionine_leucyl-phenylalanine dbr:N-formylmethionine_leucyl-phenylalanine dbr:Formyl-Met-Leu-Phe dbr:N-formyl-L-methionyl-L-leucyl-L-phenylalanine dbr:N-formyl-Met-Leu-Phe |
| is dbo:wikiPageWikiLink of |
dbr:Chemotaxis dbr:N-Formylmethionine dbr:Lipoxin dbr:Élie_Metchnikoff dbr:TEC_(gene) dbr:C21H31N3O5S dbr:GPR32 dbr:Formyl_peptide_receptor dbr:Formyl_peptide_receptor_1 dbr:Formyl_peptide_receptor_2 dbr:Formyl_peptide_receptor_3 dbr:Eicosanoid_receptor dbr:Find-me_signals dbr:FMLF dbr:FMLP dbr:Chemotactic_peptide dbr:N-Formylmethionine_leucyl-phenylalanine dbr:N-formylmethionine_leucyl-phenylalanine dbr:Specialized_pro-resolving_mediators dbr:Formyl-Met-Leu-Phe dbr:N-formyl-L-methionyl-L-leucyl-L-phenylalanine dbr:N-formyl-Met-Leu-Phe |
| is foaf:primaryTopic of |
wikipedia-en:N-Formylmethionine-leucyl-phenylalanine |
