Nucleotidyltransferase (original) (raw)
Nukleotidyltransferasen sind Enzyme, die die Übertragung von Nukleotiden auf Zielstrukturen, beispielsweise eine wachsende Nukleinsäure-Kette, katalysieren. Typische Vertreter dieser Gruppe sind DNA-Polymerasen oder reverse Transkriptasen. Die Nukleotidyltransferasen sind zentral und unentbehrlich für die Vervielfältigung des Genoms von Lebewesen und Viren. Manche der Enzyme nehmen auch Reparaturaufgaben wahr.
| Property | Value |
|---|---|
| dbo:abstract | Nukleotidyltransferasen sind Enzyme, die die Übertragung von Nukleotiden auf Zielstrukturen, beispielsweise eine wachsende Nukleinsäure-Kette, katalysieren. Typische Vertreter dieser Gruppe sind DNA-Polymerasen oder reverse Transkriptasen. Die Nukleotidyltransferasen sind zentral und unentbehrlich für die Vervielfältigung des Genoms von Lebewesen und Viren. Manche der Enzyme nehmen auch Reparaturaufgaben wahr. (de) Nucleotidyltransferases are transferase enzymes of phosphorus-containing groups, e.g., substituents of nucleotidylic acids or simply nucleoside monophosphates. The general reaction of transferring a nucleoside monophosphate moiety from A to B, can be written as: A-P-N + B A + B-P-N For example, in the case of polymerases, A is pyrophosphate and B is the nascent polynucleotide.They are classified under EC number 2.7.7 and they can be categorised into: 1. * Uridylyltransferases, which transfer uridylyl- groups 2. * Adenylyltransferases, which transfer adenylyl- groups 3. * Guanylyltransferases, which transfer guanylyl- groups 4. * , which transfer cytidylyl- groups 5. * , which transfer thymidylyl- groups (en) Les nucléotidyltransférases sont des enzymes phosphotransférases qui agissent sur des composants des nucléotides. Dans la nomenclature EC, ils sont classifiés dans le domaine 2.7.7 * Portail de la biochimie * Portail de la biologie cellulaire et moléculaire (fr) As nucleotidiltransferases são enzimas transferase de grupos contendo fósforo, por exemplo, substituintes de ácidos nucleotidílicos ou simplesmente monofosfatos de nucleósidos. A reação geral de transferir uma porção de monofosfato de nucleósido de A para B, pode ser escrita como: A - P - N + B A + B- P - N Por exemplo, no caso das polimerases, A é pirofosfato e B é o polinucleótido nascente. Eles são classificados sob o número CE 2.7.7 e podem ser categorizados em: 1. * , que transferem os grupos uridilila 2. * , que transferem grupos adenilila 3. * , que transferem grupos guanosina 4. * Cititidililtransferases, que transferem os grupos citidilila 5. * Timidililtransferases, que transferem grupos timidila (pt) 核苷酸转移酶（nucleotidyl transferase）是将核苷酸从一物质转移至另一物质的酶。包括末端核苷酸转移酶，DNA聚合酶，RNA聚合酶。 末端核苷酸转移酶（terminal nucleotidyl transferase） 这是一种在反应混合物中有任何碱基存在时能使DNA链在3′—OH端延伸的酶。可用于遗传载体的构建以产生同聚物粘性尾巴，以便达到将过客DNA拼接在质粒上的目的过客DNA和质粒分别有如聚腺苷酸和聚胸苷酸的互补碱基，因而易于退火并连接在一起，末端核苷酸转移酶在成年骨髓细胞中也表达，并产生免疫球蛋白的多样性。 DNA聚合酶（DNA polymerase） 原核生物的DNA聚合酶有3种，真核生物有5–6种主要DNA聚合酶，这些DNA聚合酶有聚合功能。 RNA聚合酶（RNA polymerase） 依赖于DNA的RNA聚合酶，以DNA为模板合成RNA。在原核生物中，一种聚合酶合成细胞所有RNA。真核生物RNA聚合酶有四个亚基，即α、β、β′和σ。大的β亚基在进化上是高度保守性的，它们与其他亚基一起是聚合的主要工具。原核生物RNA聚合酶的分子量约为500×103。α亚基识别启动子，β′亚基与DNA结合，而β亚基在RNA聚合作用中有活性。σ对起始转录是必要的。它通过打开DNA双螺旋以便让RNA聚合酶进行聚合作用这样一种特殊方式来起始转录的。真核生物的细胞器含有原核生物型RNA聚合酶。真核生物RNA聚合酶II约有10个亚基，所以要稍大一些。在宽广的系统发生范围内高度同源，最大的两个亚基与原核生物的β亚基相似。在真核细胞中有3种不同的依存在DNA的RNA聚合酶（I,II,III）。RNA聚合酶复制RNA病毒的基因组。这些酶与DNA聚合酶不同，没有校读功能，结果其错误发生率在每一个核苷酸10−3 至10−4 范围内，从而引起RNA病毒的极端多样性。 (zh) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Glutamine_synthase_regulation_by_PII_proteins.png?width=300 |
| dbo:wikiPageID | 11538526 (xsd:integer) |
| dbo:wikiPageLength | 4126 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1048222000 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Enzyme_Commission_number dbr:Uridine_monophosphate dbc:EC_2.7.7 dbr:Enzyme dbr:Adenosine_monophosphate dbr:Base_excision_repair dbr:Glycosylase dbc:Transferases dbr:Guanylyltransferase dbr:Cytidylyl dbr:Template_strand dbr:Substituent dbr:Uridylyl dbr:Uridylyltransferase dbr:Transferase dbr:Guanylyl dbr:Adenylyl dbr:Adenylyltransferase dbr:Nucleoside_monophosphate dbr:Thymidylyl dbr:File:Glutamine_synthase_regulation_by_PII_proteins.png dbr:Cytitidylyltransferase dbr:Thymidylyltransferase |
| dbp:wikiPageUsesTemplate | dbt:2.7-enzyme-stub dbt:Enzymes dbt:Kinases dbt:MeshName dbt:Portal_bar |
| dcterms:subject | dbc:EC_2.7.7 dbc:Transferases |
| rdf:type | yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Nukleotidyltransferasen sind Enzyme, die die Übertragung von Nukleotiden auf Zielstrukturen, beispielsweise eine wachsende Nukleinsäure-Kette, katalysieren. Typische Vertreter dieser Gruppe sind DNA-Polymerasen oder reverse Transkriptasen. Die Nukleotidyltransferasen sind zentral und unentbehrlich für die Vervielfältigung des Genoms von Lebewesen und Viren. Manche der Enzyme nehmen auch Reparaturaufgaben wahr. (de) Les nucléotidyltransférases sont des enzymes phosphotransférases qui agissent sur des composants des nucléotides. Dans la nomenclature EC, ils sont classifiés dans le domaine 2.7.7 * Portail de la biochimie * Portail de la biologie cellulaire et moléculaire (fr) Nucleotidyltransferases are transferase enzymes of phosphorus-containing groups, e.g., substituents of nucleotidylic acids or simply nucleoside monophosphates. The general reaction of transferring a nucleoside monophosphate moiety from A to B, can be written as: A-P-N + B A + B-P-N For example, in the case of polymerases, A is pyrophosphate and B is the nascent polynucleotide.They are classified under EC number 2.7.7 and they can be categorised into: (en) As nucleotidiltransferases são enzimas transferase de grupos contendo fósforo, por exemplo, substituintes de ácidos nucleotidílicos ou simplesmente monofosfatos de nucleósidos. A reação geral de transferir uma porção de monofosfato de nucleósido de A para B, pode ser escrita como: A - P - N + B A + B- P - N Por exemplo, no caso das polimerases, A é pirofosfato e B é o polinucleótido nascente. Eles são classificados sob o número CE 2.7.7 e podem ser categorizados em: (pt) 核苷酸转移酶（nucleotidyl transferase）是将核苷酸从一物质转移至另一物质的酶。包括末端核苷酸转移酶，DNA聚合酶，RNA聚合酶。 末端核苷酸转移酶（terminal nucleotidyl transferase） 这是一种在反应混合物中有任何碱基存在时能使DNA链在3′—OH端延伸的酶。可用于遗传载体的构建以产生同聚物粘性尾巴，以便达到将过客DNA拼接在质粒上的目的过客DNA和质粒分别有如聚腺苷酸和聚胸苷酸的互补碱基，因而易于退火并连接在一起，末端核苷酸转移酶在成年骨髓细胞中也表达，并产生免疫球蛋白的多样性。 DNA聚合酶（DNA polymerase） 原核生物的DNA聚合酶有3种，真核生物有5–6种主要DNA聚合酶，这些DNA聚合酶有聚合功能。 RNA聚合酶（RNA polymerase） (zh) |
| rdfs:label | Nukleotidyltransferase (de) Nucléotidyltransférase (fr) Nucleotidyltransferase (en) Nucleotidiltransferase (pt) 核苷酸基转移酶 (zh) |
| owl:sameAs | freebase:Nucleotidyltransferase wikidata:Nucleotidyltransferase http://bs.dbpedia.org/resource/Nukleotidiltransferaza dbpedia-de:Nucleotidyltransferase dbpedia-fr:Nucleotidyltransferase dbpedia-gl:Nucleotidyltransferase dbpedia-pt:Nucleotidyltransferase dbpedia-sh:Nucleotidyltransferase dbpedia-zh:Nucleotidyltransferase https://global.dbpedia.org/id/3o77L |
| prov:wasDerivedFrom | wikipedia-en:Nucleotidyltransferase?oldid=1048222000&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Glutamine_synthase_regulation_by_PII_proteins.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Nucleotidyltransferase |
| is dbo:wikiPageRedirects of | dbr:Uridylyltransferase dbr:Guanyltransferase dbr:Adenylyltranferase dbr:Nucleotidyl dbr:Nucleotidyl_transferase dbr:Nucleotidyltransferases |
| is dbo:wikiPageWikiLink of | dbr:Aminocyclitol dbr:MB21D1 dbr:MRNA_guanylyltransferase dbr:Sulfate_adenylyltransferase dbr:Anthranilate_adenylyltransferase dbr:Ribonuclease dbr:Cyclic_GMP-AMP_synthase dbr:D-ribitol-5-phosphate_cytidylyltransferase dbr:Degradosome dbr:ORF1ab dbr:Nucleoside-triphosphate-aldose-1-phosphate_nucleotidyltransferase dbr:(2,3-dihydroxybenzoyl)adenylate_synthase dbr:(glutamate—ammonia-ligase)_adenylyltransferase dbr:(protein-PII)_uridylyltransferase dbr:Gentamicin_2"-nucleotidyltransferase dbr:OAS1 dbr:UTP—glucose-1-phosphate_uridylyltransferase dbr:TRNA_nucleotidyltransferase dbr:Streptomycin_3"-adenylyltransferase dbr:LIG1 dbr:Choline-phosphate_cytidylyltransferase dbr:Fucose-1-phosphate_guanylyltransferase dbr:Adenosylcobinamide-phosphate_guanylyltransferase dbr:Adenylylation dbr:Adenylylsulfate—ammonia_adenylyltransferase dbr:Galactose-1-phosphate_thymidylyltransferase dbr:HEPN_domain dbr:Amikacin dbr:3-deoxy-manno-octulosonate_cytidylyltransferase dbr:Pantetheine-phosphate_adenylyltransferase dbr:Capping_enzyme dbr:Glucose-1-phosphate_adenylyltransferase dbr:Glucose-1-phosphate_cytidylyltransferase dbr:Glucose-1-phosphate_guanylyltransferase dbr:Glucose-1-phosphate_thymidylyltransferase dbr:Glucuronate-1-phosphate_uridylyltransferase dbr:Glycerol-3-phosphate_cytidylyltransferase dbr:Glycorandomization dbr:List_of_EC_numbers_(EC_2) dbr:2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase dbr:ATP_adenylyltransferase dbr:Aldose-1-phosphate_adenylyltransferase dbr:Aldose-1-phosphate_nucleotidyltransferase dbr:Holo-ACP_synthase dbr:UTP-monosaccharide-1-phosphate_uridylyltransferase dbr:CGAS–STING_cytosolic_DNA_sensing_pathway dbr:Guanosine-triphosphate_guanylyltransferase dbr:Nicotinamide-nucleotide_adenylyltransferase dbr:Nicotinate-nucleotide_adenylyltransferase dbr:UDP-glucose—hexose-1-phosphate_uridylyltransferase dbr:UDP-N-acetylglucosamine_diphosphorylase dbr:Ethanolamine-phosphate_cytidylyltransferase dbr:FAM46C dbr:FMN_adenylyltransferase dbr:RNA_uridylyltransferase dbr:Planarian_secretory_cell_nidovirus dbr:Mannose-1-phosphate_guanylyltransferase dbr:Mannose-1-phosphate_guanylyltransferase_(GDP) dbr:N-acylneuraminate_cytidylyltransferase dbr:N-methylphosphoethanolamine_cytidylyltransferase dbr:Sulfate_adenylyltransferase_(ADP) dbr:Phosphatidate_cytidylyltransferase dbr:Polynucleotide_adenylyltransferase dbr:Phenylalanine_adenylyltransferase dbr:UTP—xylose-1-phosphate_uridylyltransferase dbr:Ribose-5-phosphate_adenylyltransferase dbr:Uridylyltransferase dbr:UTP—hexose-1-phosphate_uridylyltransferase dbr:Guanyltransferase dbr:Adenylyltranferase dbr:Nucleotidyl dbr:Nucleotidyl_transferase dbr:Nucleotidyltransferases |
| is foaf:primaryTopic of | wikipedia-en:Nucleotidyltransferase |
