| dbo:abstract |
In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction ATP + sulfate pyrophosphate + adenylyl sulfate Thus, the two substrates of this enzyme are ATP and sulfate, whereas its two products are pyrophosphate and adenylyl sulfate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:sulfate adenylyltransferase. Other names in common use include adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, adenylylsulfate pyrophosphorylase, ATP sulfurylase, ATP-sulfurylase, and sulfurylase. This enzyme participates in 3 metabolic pathways: purine metabolism, , and sulfur metabolism. Some sulfate adenylyltransferases are part of a bifunctional polypeptide chain associated with adenosyl phosphosulfate (APS) kinase. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulfate. Within the cell Sulfate adenylyltransferase plays a key role in both assimilatory sulfur reduction and dissimilatory sulfur oxidation and reduction (DSR) and participates in the biogeochemically relevant sulfur cycle. In dissimilatory sulfate reduction the SAT enzyme, acts as the first priming step in the reduction converting sulfate(+6) to Adenosine 5'-phosphosulfate (APS) via adenylation at the cost of an ATP. If the organisms participating in the DSR pathway possess the full suite of genes necessary, APS can then be further stepwise reduced to sulfite(+4) and then sulfide (-2). Conversely in the process of dissimilatory sulfate oxidation, pyrophosphate combines with APS in a sulfate adenylyltransferase catalyzed reaction to form sulfate. In either direction in which the Sulfate adenylyltransferase (reduction or oxidation) proceeds along DSR in bacterial cells, the associated pathways are participating in cellular respiration necessary for the growth of the organism. (en) |
| dbo:ecNumber |
2.7.7.4 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/3cr8.jpg?width=300 |
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14681411 (xsd:integer) |
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dbr:Pyrophosphate dbr:List_of_enzymes dbr:Nucleotide dbr:Nucleotidyltransferase dbr:Enzymology dbc:EC_2.7.7 dbc:Enzymes_of_known_structure dbr:Chemical_reaction dbr:Pyrosequencing dbr:Enzyme dbr:Protein_Data_Bank dbr:Substrate_(biochemistry) dbr:Adenylyl-sulfate_kinase dbr:Adenylylation dbr:3'-Phosphoadenosine-5'-phosphosulfate dbr:Adenosine_triphosphate dbr:Product_(chemistry) dbr:Sulfate dbr:Tertiary_structure dbr:Purine_metabolism dbr:Polymer dbr:Metabolism dbr:Catalysis dbr:Inorganic dbr:Sulfur_metabolism dbr:Transferase dbr:Polypeptide dbr:Selenoamino_acid_metabolism |
| dbp:caption |
Sulfate adenylyltransferase homohexamer, Thiobacillus denitrificans (en) crystal structure of atp sulfurylase from thermus thermophillus hb8 in complex with aps (en) |
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9012 (xsd:integer) |
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2.700000 (xsd:double) |
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| dbp:interpro |
IPR002650 (en) |
| dbp:iubmbEcNumber |
2 (xsd:integer) |
| dbp:name |
ATP-sulfurylase (en) sulfate adenylyltransferase (en) |
| dbp:pfam |
PF01747 (en) |
| dbp:scop |
172800.0 |
| dbp:symbol |
ATP-sulfurylase (en) |
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270 (xsd:integer) |
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| dcterms:subject |
dbc:EC_2.7.7 dbc:Enzymes_of_known_structure |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Enzyme yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment |
In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction ATP + sulfate pyrophosphate + adenylyl sulfate Thus, the two substrates of this enzyme are ATP and sulfate, whereas its two products are pyrophosphate and adenylyl sulfate. Some sulfate adenylyltransferases are part of a bifunctional polypeptide chain associated with adenosyl phosphosulfate (APS) kinase. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulfate. (en) |
| rdfs:label |
Sulfate adenylyltransferase (en) |
| owl:sameAs |
freebase:Sulfate adenylyltransferase http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/2813 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/2895 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/5412 wikidata:Sulfate adenylyltransferase dbpedia-sh:Sulfate adenylyltransferase dbpedia-sr:Sulfate adenylyltransferase https://global.dbpedia.org/id/4vVQE |
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wikipedia-en:Sulfate_adenylyltransferase?oldid=1075831982&ns=0 |
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wikipedia-en:Sulfate_adenylyltransferase |
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sulfate adenylyltransferase (ATP) (en) |
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dbr:Pyrosequencing dbr:Li_Jiayang dbr:Sulfurylase dbr:Dissimilatory_sulfate_reduction dbr:List_of_EC_numbers_(EC_2) dbr:List_of_MeSH_codes_(D08) dbr:Sulfur_metabolism dbr:Adenosine-5'-triphosphate_sulfurylase dbr:Adenosinetriphosphate_sulfurylase dbr:Adenylylsulfate_pyrophosphorylase dbr:EC_2.7.7.4 dbr:ATP-sulfurylase dbr:ATP-sulphurylase dbr:ATP:sulfate_adenylyltransferase dbr:ATP_sulfurylase |
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