| dbo:abstract |
اوماسيتاكسن (بالإنجليزية: Omacetaxine) أحد العلاجات الحديثة لمرض ابيضاض الدم النقوي المزمن. اعتمد من قبل إدارة الأغذية والأدوية الأمريكية في أكتوبر 2012. (ar) Homoharringtonin ist ein Alkaloid aus der Gruppe der Cephalotaxus-Alkaloide. (de) Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid leukemia (CML). HHT is a natural plant alkaloid derived from Cephalotaxus fortunei. HHT and related compound esters of were described first in 1970, and were the subject of intensive research efforts by Chinese investigators to clarify their role as anticancer and antileukemic agents from the 1970s until the present. It was approved by the US FDA in October 2012 for the treatment of adult patients with CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKIs). (en) オマセタキシンメペスクシナート（国際一般名、omacetaxine mepesuccinate）は、慢性骨髄性白血病（CML）治療に適応される医薬品化合物である。別名はホモハリングトニン（homoharringtonine、略称: HHT）。商品名はSynriboまたはMyelostat。イチイ科の針葉樹イヌガヤ（Cephalotaxus harringtonii）から1970年に単離・構造決定された天然物であり、現在は半合成によって製造されている。化合物名はイヌガヤの学名に由来する。2012年10月に、2種類以上の（TKIs）に抵抗性、不忍容性の両方またはいずれか一方の成人CML患者の治療薬としてアメリカ食品医薬品局（FDA）に承認された。 (ja) |
| dbo:alternativeName |
Synribo (en) |
| dbo:casNumber |
26833-87-4 |
| dbo:chEBI |
71019 |
| dbo:fdaUniiCode |
6FG8041S5B |
| dbo:kegg |
D08956 |
| dbo:pubchem |
285033 |
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wiki-commons:Special:FilePath/Omacetaxine_mepesuccinate.svg?width=300 |
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| dbp:chemspiderid |
251215 (xsd:integer) |
| dbp:eliminationHalfLife |
21600.0 (dbd:second) |
| dbp:excretion |
Urine (en) |
| dbp:h |
39 (xsd:integer) |
| dbp:image |
Omacetaxine_mepesuccinate3DS.svg (en) |
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1 (xsd:integer) |
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| dbp:kegg |
D08956 (en) |
| dbp:legalUs |
Rx-only (en) |
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Omacetaxine_mepesuccinate (en) |
| dbp:metabolism |
Mostly via plasma esterases (en) |
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1 (xsd:integer) |
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9 (xsd:integer) |
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D (en) |
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| dbp:smiles |
CCO (en) |
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HYFHYPWGAURHIV-JFIAXGOJSA-N (en) |
| dbp:tradename |
Synribo (en) |
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6 (xsd:integer) |
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| gold:hypernym |
dbr:Substance |
| rdf:type |
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| rdfs:comment |
اوماسيتاكسن (بالإنجليزية: Omacetaxine) أحد العلاجات الحديثة لمرض ابيضاض الدم النقوي المزمن. اعتمد من قبل إدارة الأغذية والأدوية الأمريكية في أكتوبر 2012. (ar) Homoharringtonin ist ein Alkaloid aus der Gruppe der Cephalotaxus-Alkaloide. (de) Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid leukemia (CML). HHT is a natural plant alkaloid derived from Cephalotaxus fortunei. HHT and related compound esters of were described first in 1970, and were the subject of intensive research efforts by Chinese investigators to clarify their role as anticancer and antileukemic agents from the 1970s until the present. It was approved by the US FDA in October 2012 for the treatment of adult patients with CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKIs). (en) オマセタキシンメペスクシナート（国際一般名、omacetaxine mepesuccinate）は、慢性骨髄性白血病（CML）治療に適応される医薬品化合物である。別名はホモハリングトニン（homoharringtonine、略称: HHT）。商品名はSynriboまたはMyelostat。イチイ科の針葉樹イヌガヤ（Cephalotaxus harringtonii）から1970年に単離・構造決定された天然物であり、現在は半合成によって製造されている。化合物名はイヌガヤの学名に由来する。2012年10月に、2種類以上の（TKIs）に抵抗性、不忍容性の両方またはいずれか一方の成人CML患者の治療薬としてアメリカ食品医薬品局（FDA）に承認された。 (ja) |
| rdfs:label |
أوماسيتاكسين (ar) Homoharringtonin (de) オマセタキシンメペスクシナート (ja) Omacetaxine mepesuccinate (en) |
| owl:sameAs |
freebase:Omacetaxine mepesuccinate yago-res:Omacetaxine mepesuccinate wikidata:Omacetaxine mepesuccinate dbpedia-ar:Omacetaxine mepesuccinate dbpedia-de:Omacetaxine mepesuccinate dbpedia-hu:Omacetaxine mepesuccinate dbpedia-ja:Omacetaxine mepesuccinate dbpedia-sh:Omacetaxine mepesuccinate dbpedia-sr:Omacetaxine mepesuccinate dbpedia-vi:Omacetaxine mepesuccinate https://global.dbpedia.org/id/4sce8 |
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wikipedia-en:Omacetaxine_mepesuccinate?oldid=1092836773&ns=0 |
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dbr:Alkaloid dbr:Natural_product dbr:Synribo dbr:ATC_code_L01XX40 dbr:ATCvet_code_QL01XX40 dbr:ATC_code_L01 dbr:MCL1 dbr:Ceflatonin dbr:List_of_drugs:_O–Op dbr:Omapro dbr:Homoharringtonine dbr:Omacetaxine |
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wikipedia-en:Omacetaxine_mepesuccinate |
