PLD3 (original) (raw)
Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, it has no known catalytic function similar to PLD1 or PLD2. PLD3 serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3 is highly expressed in the brain in both humans and mice, and is mainly localized in the endoplasmic reticulum (ER) and the lysosome.
| Property | Value |
|---|---|
| dbo:abstract | Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, it has no known catalytic function similar to PLD1 or PLD2. PLD3 serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3 is highly expressed in the brain in both humans and mice, and is mainly localized in the endoplasmic reticulum (ER) and the lysosome. PLD3 may play a role in regulating the lysosomal system, myogenesis, late-stage neurogenesis, inhibiting insulin signal transduction, and amyloid precursor protein (APP) processing. The involvement in PLD3 in the lysosomal system and in APP processing and the loss-of-function mutations in PLD3 are thought to be linked to late-onset Alzheimer's disease (LOAD). However, there are also studies that challenge the association between PLD3 and Alzheimer's disease (AD). How APP processing is affected by PLD3 during AD still remains unclear, and its role in the pathogenesis of AD is ambiguous. PLD3 may contribute to the onset of AD by a mechanism other than by influencing APP metabolism, with one proposed mechanism suggesting that PLD3 contributes to the onset of AD by impairing the endosomal-lysosomal system. In 2017, PLD3 was shown to have an association with another neurodegenerative disease, spinocerebellar ataxia. (en) PLD3 (англ. Phospholipase D family member 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми. Довжина поліпептидного ланцюга білка становить 490 амінокислот, а молекулярна маса — 54 705. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до гідролаз. Задіяний у таких біологічних процесах, як метаболізм ліпідів, деградація ліпідів. Локалізований у мембрані, ендоплазматичному ретикулумі. (uk) |
| dbo:wikiPageID | 46300275 (xsd:integer) |
| dbo:wikiPageLength | 26728 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1113075036 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:5'_UTR dbr:Endoplasmic_reticulum dbr:Messenger_RNA dbr:Mutation dbr:Meta-analysis dbr:DNA dbr:Valine dbr:Inflammation dbr:LAMP1 dbr:LAMP2 dbr:Protein_disulfide-isomerase dbr:Protein_phosphorylation dbc:EC_3.1.4 dbr:Amyloid dbr:Amyloid_beta dbr:Neuron dbr:Frontal_lobe dbr:Gene dbr:Hematopoietic_stem_cell dbr:Protein_kinase_B dbr:Protein_superfamily dbr:Stop_codon dbr:Neurotransmission dbr:Active_site dbr:Prenylation dbr:Amyloid_precursor_protein dbr:Alternative_splicing dbr:Base_pair dbr:Chromosome dbr:Forebrain dbr:Glycosylation dbr:Granule_(cell_biology) dbr:Granulin dbr:Hippocampus dbr:Protein_domain dbr:Protein_family dbr:Protein dbr:HindIII dbr:Temporal_lobe dbr:Transmembrane_protein dbr:TLR9 dbr:Signal_transduction dbr:Missense_mutation dbr:C-terminus dbr:Spinocerebellar_ataxia dbr:Insulin dbr:Methionine dbr:Occipital_lobe dbr:Cerebral_cortex dbr:Single-nucleotide_polymorphism dbr:Wild_type dbr:Neurogenesis dbr:Late-onset_Alzheimer's_Disease dbr:Short_hairpin_RNA dbr:Exon dbr:Exonuclease dbr:Lysosome dbr:Myogenesis dbr:N-terminus dbr:Phospholipase_D dbr:Phospholipase_D1 dbr:Phagolysosome dbr:Oxidative_stress dbr:PLD2 dbr:Vaccinia dbr:Pancreatic_beta_cell dbr:Myoblasts dbr:N-glycosylation dbr:ER_stress dbr:Loss_of_function |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:Clear dbt:Enzymes dbt:Esterases dbt:Infobox_gene dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:NLM_content |
| dcterms:subject | dbc:EC_3.1.4 |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, it has no known catalytic function similar to PLD1 or PLD2. PLD3 serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3 is highly expressed in the brain in both humans and mice, and is mainly localized in the endoplasmic reticulum (ER) and the lysosome. (en) PLD3 (англ. Phospholipase D family member 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми. Довжина поліпептидного ланцюга білка становить 490 амінокислот, а молекулярна маса — 54 705. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PLD3 (en) PLD3 (uk) |
| owl:sameAs | freebase:PLD3 wikidata:PLD3 http://tt.dbpedia.org/resource/PLD3 dbpedia-uk:PLD3 https://global.dbpedia.org/id/jg16 |
| prov:wasDerivedFrom | wikipedia-en:PLD3?oldid=1113075036&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:PLD3 |
| is dbo:wikiPageRedirects of | dbr:HU-K4 dbr:HUK4 dbr:Phospholipase_D_family,_member_3 dbr:AD19 |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_3 dbr:HU-K4 dbr:HUK4 dbr:Phospholipase_D dbr:Phospholipase_D_family,_member_3 dbr:AD19 |
| is foaf:primaryTopic of | wikipedia-en:PLD3 |