Pancreatic enzymes (medication) (original) (raw)
إنزيمات البنكرياس والمعروفة أيضًا باسم البنكرييز والبنكرياسين، وهي خليط من الأميلايز، والليبايز، والبروتيايزيتم ،
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| dbo:abstract | إنزيمات البنكرياس والمعروفة أيضًا باسم البنكرييز والبنكرياسين، وهي خليط من الأميلايز، والليبايز، والبروتيايزيتم ، (ar) La Pancrelipasa es una forma de terapia enzimática para el tratamiento de varios desórdenes digestivos, primordialmente insuficiencia pancreática exocrina. Es una mezcla de tres enzimas digestivas: amilasa, tripsina y lipasa, las cuales son normalmente producidas por el páncreas. La pancrelipasa es utilizada en pacientes con fibrosis quística cuyos conductos pancreáticos se hallan obstruidos con secreción mucosa. Esta obstrucción impide que las enzimas digestivas producidas por el páncreas lleguen al intestino, en donde son requeridas para la digestión. La pancrealipasa también se emplea en personas con pancreatitis crónica. (es) Pancreatic enzymes, also known as pancreases or pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to certain pancreatic problems. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, or pancreatic cancer, among others. The preparation is taken by mouth. Common side effects include vomiting, abdominal pain, constipation, and diarrhea. Other side effects include perianal irritation and high blood uric acid. The enzymes are from pigs. Use is believed to be safe during pregnancy. The components are digestive enzymes similar to those normally produced by the human pancreas. They help the person digest fats, starches, and proteins. Pancreatic enzymes have been used as medications since at least the 1800s. They are on the World Health Organization's List of Essential Medicines. In 2020, it was the 262nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. (en) Enzimas pancreáticas são misturas comerciais de amilase, lipase e protease. Elas são usadas para tratar o síndrome de má-absorção, devido a problemas no pâncreas. Estes problemas pancreáticos podem ser devido a fibrose cística, a remoção cirúrgica do pâncreas, a longo prazo, pancreatite ou câncer de pâncreas, entre outros. Isto é tomado por via oral. Efeitos secundários comuns incluem vómitos, dor abdominal, constipação e diarreia. Outros efeitos secundários incluem irritação perianal e hiperuricemia. As enzimas são de porcos. Acredita-se que o uso possa ser seguro durante a gravidez. Os componentes são enzimas digestivas similares àquelas normalmente produzidas pelo pâncreas humano. Elas ajudam a pessoa a digerir gorduras, amidos e proteínas. Enzimas pancreáticas são utilizadas como medicamentos pelo menos desde os anos 1800. Faz parte da Lista de Medicamentos Essenciais da Organização Mundial de Saúde, uma lista dos mais eficazes e seguros medicamentos que são necessários em um sistema de saúde. No Reino Unido, um mês típico de abastecimento custa ao SNS cerca de 11.64 libras. Nos Estados Unidos um mês de tratamento, normalmente, tem um custo que varia entre 50 a 100 dólares. (pt) 胰脂肪酶（Pancrelipases），特別是它的緩釋劑型(例如： Creon, Pancreaze, Pertzye, Ultresa, Zenpep) 是豬源性胰澱粉酶的商用混合物(作用於)，胰脂肪酶和胰凝乳蛋白酶（一種蛋白酶），其治療目的是為了給那些沒有足夠的嬰兒、小孩、成人在食物消化上的改善，因為它們會影響胰腺，如囊性纖維化、慢性胰腺炎或在胰腺和腸之間的通道堵塞等作用。這產品中的三個組成部分是類似那些通常由人類胰腺產生的消化酶。長期的胰腺酶替代產品（PERPs），有一些甚至使用了一個多世紀，2006年美國食品藥品管理局要求製藥公司提交豬源性PERP產品的保密合約；Creon®（AbbVie公司）是最早的美國食品藥品管理局指令後，批准商業PERP產品的公司，在2009年正式在市場上市。 胰脂肪酶通常是用在治療外分泌胰腺功能和一些不消化上的疾病，伴隨囊性纖維化，胰臟切除手術併發症，或慢性胰腺炎的第一個方法。製劑通常填充在硬質膠囊裡以耐胃酸顆粒。胰脂肪酶類似於胰液，但具有較多的脂肪酶成分。 美國食品藥品管理局具體要求製造商提交風險評估、REMS和用藥指南，以確保病人充分了解有關於高劑量的豬源性PERP產品管理相關的潛在風險，特別是關於「從豬身上傳染病毒性疾病到患者的理論風險」，病人對藥的依賴性（用藥量）應減少到藥品標籤之劑量用量。 (zh) |
| dbo:alternativeName | Creon, Pancreaze, Pancrex, [[#Brand names (en) |
| dbo:casNumber | 53608-75-6 |
| dbo:drugbank | DB00085 |
| dbo:fdaUniiCode | FQ3DRG0N5K |
| dbo:medlinePlus | a604035 |
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| dbo:wikiPageWikiLink | dbr:Pregnancy dbr:New_Drug_Application dbr:Anus dbr:Cystic_fibrosis dbc:Enzymes dbr:Pancreatic_lipase_family dbr:Colipase dbr:Enzyme dbr:Contact_lens dbr:Pancreatic_cancer dbr:Malabsorption dbr:Lipase dbr:Amylase dbc:Wikipedia_medicine_articles_ready_to_translate dbc:World_Health_Organization_essential_medicines dbr:Exocrine_pancreatic_insufficiency dbr:FDA dbr:Fibrosing_colonopathy dbr:Pancreas dbr:Pancreatectomy dbr:Chronic_pancreatitis dbr:Diarrhea dbr:Digestion dbr:Digestive_enzyme dbr:Formulation dbr:Vomiting dbr:Protease dbr:Hyperuricemia dbc:AbbVie_brands dbr:Pig dbr:World_Health_Organization's_List_of_Essential_Medicines dbr:Trypsin dbr:Exocrine_gland dbr:Pancreatitis dbr:Pancreatic_enzyme |
| dbp:atcPrefix | A09 (en) |
| dbp:atcSuffix | AA02 (en) |
| dbp:caption | Complex of lipase with colipase (en) |
| dbp:casNumber | 53608 (xsd:integer) |
| dbp:chemspiderid | none (en) |
| dbp:drugName | Pancreatic enzymes (en) |
| dbp:drugbank | DB00085 (en) |
| dbp:legalStatus | Rx-only (en) |
| dbp:medlineplus | a604035 (en) |
| dbp:pregnancyCategory | C (en) |
| dbp:pregnancyUs | C (en) |
| dbp:routesOfAdministration | by mouth (en) |
| dbp:tradename | Creon, Pancreaze, Pancrex, [[#Brand names (en) |
| dbp:unii | FQ3DRG0N5K (en) |
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| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | إنزيمات البنكرياس والمعروفة أيضًا باسم البنكرييز والبنكرياسين، وهي خليط من الأميلايز، والليبايز، والبروتيايزيتم ، (ar) La Pancrelipasa es una forma de terapia enzimática para el tratamiento de varios desórdenes digestivos, primordialmente insuficiencia pancreática exocrina. Es una mezcla de tres enzimas digestivas: amilasa, tripsina y lipasa, las cuales son normalmente producidas por el páncreas. La pancrelipasa es utilizada en pacientes con fibrosis quística cuyos conductos pancreáticos se hallan obstruidos con secreción mucosa. Esta obstrucción impide que las enzimas digestivas producidas por el páncreas lleguen al intestino, en donde son requeridas para la digestión. La pancrealipasa también se emplea en personas con pancreatitis crónica. (es) 胰脂肪酶（Pancrelipases），特別是它的緩釋劑型(例如： Creon, Pancreaze, Pertzye, Ultresa, Zenpep) 是豬源性胰澱粉酶的商用混合物(作用於)，胰脂肪酶和胰凝乳蛋白酶（一種蛋白酶），其治療目的是為了給那些沒有足夠的嬰兒、小孩、成人在食物消化上的改善，因為它們會影響胰腺，如囊性纖維化、慢性胰腺炎或在胰腺和腸之間的通道堵塞等作用。這產品中的三個組成部分是類似那些通常由人類胰腺產生的消化酶。長期的胰腺酶替代產品（PERPs），有一些甚至使用了一個多世紀，2006年美國食品藥品管理局要求製藥公司提交豬源性PERP產品的保密合約；Creon®（AbbVie公司）是最早的美國食品藥品管理局指令後，批准商業PERP產品的公司，在2009年正式在市場上市。 胰脂肪酶通常是用在治療外分泌胰腺功能和一些不消化上的疾病，伴隨囊性纖維化，胰臟切除手術併發症，或慢性胰腺炎的第一個方法。製劑通常填充在硬質膠囊裡以耐胃酸顆粒。胰脂肪酶類似於胰液，但具有較多的脂肪酶成分。 美國食品藥品管理局具體要求製造商提交風險評估、REMS和用藥指南，以確保病人充分了解有關於高劑量的豬源性PERP產品管理相關的潛在風險，特別是關於「從豬身上傳染病毒性疾病到患者的理論風險」，病人對藥的依賴性（用藥量）應減少到藥品標籤之劑量用量。 (zh) Pancreatic enzymes, also known as pancreases or pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to certain pancreatic problems. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, or pancreatic cancer, among others. The preparation is taken by mouth. (en) Enzimas pancreáticas são misturas comerciais de amilase, lipase e protease. Elas são usadas para tratar o síndrome de má-absorção, devido a problemas no pâncreas. Estes problemas pancreáticos podem ser devido a fibrose cística, a remoção cirúrgica do pâncreas, a longo prazo, pancreatite ou câncer de pâncreas, entre outros. Isto é tomado por via oral. (pt) |
| rdfs:label | إنزيمات البنكرياس (دواء) (ar) Pancrelipasa (es) Pancreatic enzymes (medication) (en) Enzimas pancreáticas (medicação) (pt) 胰脂肪酶 (zh) |
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