Pimozide (original) (raw)

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Pimozid (Handelsname Orap) ist ein Arzneistoff aus der Gruppe der Antipsychotika, der in Form von Tabletten in der Behandlung von chronischen Psychosen des schizophrenen Formenkreises eingesetzt wird.

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dbo:abstract Pimozid (Handelsname Orap) ist ein Arzneistoff aus der Gruppe der Antipsychotika, der in Form von Tabletten in der Behandlung von chronischen Psychosen des schizophrenen Formenkreises eingesetzt wird. (de) بيموزيد (بالإنجليزية: Pimozide)‏ هو دواء يُستعمل في علاج: * متلازمة توريت * داء هنتنغتون (ar) Le pimozide (Orap, R6238) est un antipsychotique typique de la famille des diphénylpipéridines.C'est un puissant antagoniste des récepteurs D2 et D3 à la dopamine et 5HT2A à la sérotonine. (fr) Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome and resistant tics. The side effects include akathisia, tardive dyskinesia, and, more rarely, neuroleptic malignant syndrome and prolongation of the QT interval. (en) Pimozide è un farmaco antipsicotico, derivato della difenilbutilpiperidina (similmente a penfluridolo e fluspirilene). È stato sintetizzato nei laboratori della Janssen Pharmaceutica nel 1963. Ha una elevata potenza rispetto alla clorpromazina (il rapporto è di circa 50 a 1). Sulla base del peso è ancora più potente dell'aloperidolo. Il farmaco presenta particolari indicazioni neurologiche nella Sindrome di Tourette e nei soggetti affetti da tic non rispondenti ad altri farmaci. In Italia il farmaco è venduto dalla società farmaceutica Janssen-Cilag con il nome commerciale di Orap, nella forma farmaceutica di compresse da 4 mg. (it) Pimozide (op de markt gebracht onder de naam Orap) is een klassiek antipsychoticum, dat sinds 1969 verkrijgbaar is. De dosering bedraagt 2 tot 20 mg en de werkingsduur van het middel is ongeveer 55 uur.Pimozide is een antipsychotisch geneesmiddel dat in 1963 ontwikkeld werd in het laboratorium van het Belgische bedrijf Janssen Pharmaceutica, net als enkele jaren eerder het zwaardere antipsychoticum haloperidol. Pimozide behoort tot de groep klassieke of "typische" antipsychotica. Chemisch gezien is het een difenylbutylpiperidine. Het vermindert in de hersenen het effect van de natuurlijk voorkomende stof dopamine. Hierdoor kunnen psychosen, hevige onrust en bepaalde spiertrekkingen afnemen. Het middel wordt door artsen voorgeschreven bij psychose, manie, , schizofrenie, depressie, dementie, Tourette en tics, maar omdat het een sterk middel is met verschillende bijwerkingen wordt het hoofdzakelijk gegeven wanneer andere middelen niet blijken te werken. Ook kan het voorgeschreven worden ter voorkoming van psychosen bij schizofrenie en bij schizoaffectieve stoornis. (nl) ピモジド（英: Pimozide）とは神経遮断薬の1つ。主に統合失調症の治療に用いられ、小児の自閉性障害にも効果がある。日本ではアステラス製薬より商品名オーラップとして承認された。 (ja) Pimozid är ett neuroleptikum. Pimozid är i Sverige avregistrerat och finns således ej längre med i FASS. Det säljs i andra länder än Sverige under namnet Orap®. Pimozid var det första och länge det enda neuroleptikum som i Sverige var inregistrerat för behandling av Tourettes syndrom - även om också haloperidol (Haldol) anses ha effekt mot detta syndrom. Denna läkemedels- eller farmakologi-relaterade artikel saknar väsentlig information. Du kan hjälpa till genom att lägga till den. (sv) Pimozida é um fármaco, utilizado pela medicina como antipsicótico. Age bloqueando os receptores dopaminérgicos, a nível neuronal. Além disso bloqueia também os receptores muscarínicos, alfa-1 e H1. É indicados para pacientes com a síndrome de Gilles de la Tourette, autismo, demência e coreia de Huntington. (pt) Пимозид (Pimozidum) — антипсихотическое средство класса дифенилбутилпиперидинов. Синонимы: Орап (оральный антипсихотик), Antalon, Norofen, Opiran, Oralep, Orap, Pimotid, Pirium. (ru) 雙氟苯丁哌啶苯並咪唑酮（Pimozide；哌迷清；派脈淨；匹莫齊特；商標名 Orap）是類的抗精神病藥藥品。它於1963年由所研發。與氯丙嗪相比具有高效力（比例50-70：1）。在重量基礎上，它比氟哌啶醇更有效。對於妥瑞症及耐藥性抽動綜合症，哌迷清還具有特殊的神經系統適應功效。副作用包括静坐不能、遲發性運動障礙，以及更罕見的與QT間期的延長。 (zh) Пімозид — синтетичний антипсихотичний препарат, що є похідним , для перорального застосування. Пімозид уперше синтезований у Бельгії в лабораторії компанії «Janssen Pharmaceutica» у 1963 році. (uk)
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rdfs:comment Pimozid (Handelsname Orap) ist ein Arzneistoff aus der Gruppe der Antipsychotika, der in Form von Tabletten in der Behandlung von chronischen Psychosen des schizophrenen Formenkreises eingesetzt wird. (de) بيموزيد (بالإنجليزية: Pimozide)‏ هو دواء يُستعمل في علاج: * متلازمة توريت * داء هنتنغتون (ar) Le pimozide (Orap, R6238) est un antipsychotique typique de la famille des diphénylpipéridines.C'est un puissant antagoniste des récepteurs D2 et D3 à la dopamine et 5HT2A à la sérotonine. (fr) Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome and resistant tics. The side effects include akathisia, tardive dyskinesia, and, more rarely, neuroleptic malignant syndrome and prolongation of the QT interval. (en) Pimozide è un farmaco antipsicotico, derivato della difenilbutilpiperidina (similmente a penfluridolo e fluspirilene). È stato sintetizzato nei laboratori della Janssen Pharmaceutica nel 1963. Ha una elevata potenza rispetto alla clorpromazina (il rapporto è di circa 50 a 1). Sulla base del peso è ancora più potente dell'aloperidolo. Il farmaco presenta particolari indicazioni neurologiche nella Sindrome di Tourette e nei soggetti affetti da tic non rispondenti ad altri farmaci. In Italia il farmaco è venduto dalla società farmaceutica Janssen-Cilag con il nome commerciale di Orap, nella forma farmaceutica di compresse da 4 mg. (it) ピモジド（英: Pimozide）とは神経遮断薬の1つ。主に統合失調症の治療に用いられ、小児の自閉性障害にも効果がある。日本ではアステラス製薬より商品名オーラップとして承認された。 (ja) Pimozid är ett neuroleptikum. Pimozid är i Sverige avregistrerat och finns således ej längre med i FASS. Det säljs i andra länder än Sverige under namnet Orap®. Pimozid var det första och länge det enda neuroleptikum som i Sverige var inregistrerat för behandling av Tourettes syndrom - även om också haloperidol (Haldol) anses ha effekt mot detta syndrom. Denna läkemedels- eller farmakologi-relaterade artikel saknar väsentlig information. Du kan hjälpa till genom att lägga till den. (sv) Pimozida é um fármaco, utilizado pela medicina como antipsicótico. Age bloqueando os receptores dopaminérgicos, a nível neuronal. Além disso bloqueia também os receptores muscarínicos, alfa-1 e H1. É indicados para pacientes com a síndrome de Gilles de la Tourette, autismo, demência e coreia de Huntington. (pt) Пимозид (Pimozidum) — антипсихотическое средство класса дифенилбутилпиперидинов. Синонимы: Орап (оральный антипсихотик), Antalon, Norofen, Opiran, Oralep, Orap, Pimotid, Pirium. (ru) 雙氟苯丁哌啶苯並咪唑酮（Pimozide；哌迷清；派脈淨；匹莫齊特；商標名 Orap）是類的抗精神病藥藥品。它於1963年由所研發。與氯丙嗪相比具有高效力（比例50-70：1）。在重量基礎上，它比氟哌啶醇更有效。對於妥瑞症及耐藥性抽動綜合症，哌迷清還具有特殊的神經系統適應功效。副作用包括静坐不能、遲發性運動障礙，以及更罕見的與QT間期的延長。 (zh) Пімозид — синтетичний антипсихотичний препарат, що є похідним , для перорального застосування. Пімозид уперше синтезований у Бельгії в лабораторії компанії «Janssen Pharmaceutica» у 1963 році. (uk) Pimozide (op de markt gebracht onder de naam Orap) is een klassiek antipsychoticum, dat sinds 1969 verkrijgbaar is. De dosering bedraagt 2 tot 20 mg en de werkingsduur van het middel is ongeveer 55 uur.Pimozide is een antipsychotisch geneesmiddel dat in 1963 ontwikkeld werd in het laboratorium van het Belgische bedrijf Janssen Pharmaceutica, net als enkele jaren eerder het zwaardere antipsychoticum haloperidol. (nl)
rdfs:label بيموزيد (ar) Pimozid (de) Pimozide (fr) Pimozide (it) ピモジド (ja) Pimozide (nl) Pimozide (en) Pimozida (pt) Пимозид (ru) Pimozid (sv) Пімозид (uk) 雙氟苯丁哌啶苯並咪唑酮 (zh)
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