Porocarcinoma (original) (raw)
Das Porokarzinom (lateinisch ‚porus‘ aus altgriechisch ‚πὀρος‘, poros, Öffnung, Loch, Pore) ist ein seltener, maligner, vom intraepidermalen Teil des ekkrinen Schweißdrüsenausführungsganges ausgehender, infiltrierend wachsender Tumor. Charakteristisch ist das retrograde Einwachsen in die Epidermis. Manchmal entstehen Porokarzinome auch durch Entartung gutartiger Schweißdrüsentumore.
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| dbo:abstract | Das Porokarzinom (lateinisch ‚porus‘ aus altgriechisch ‚πὀρος‘, poros, Öffnung, Loch, Pore) ist ein seltener, maligner, vom intraepidermalen Teil des ekkrinen Schweißdrüsenausführungsganges ausgehender, infiltrierend wachsender Tumor. Charakteristisch ist das retrograde Einwachsen in die Epidermis. Manchmal entstehen Porokarzinome auch durch Entartung gutartiger Schweißdrüsentumore. Das Porokarzinom tritt vor allem bei älteren Menschen, vorzugsweise an den Gliedmaßenenden (Hand, Fuß), auf. Klinisch zeigt sich der Tumor als unscharf begrenzter, geschwürig veränderter Knoten, der mit einer aktinischen Keratose oder mit einem Plattenepithelkarzinom verwechselt werden kann. Zum Zeitpunkt der Diagnose liegen häufig bereits Metastasen der Lymphknoten mit Lymphödemen vor. Metastasen entstehen zumeist an anderen Hautstellen. Über das Blut verbreitete Fernmetastasen in anderen Organen kommen erst im Spätstadium vor. (de) Porocarcinoma (PCA) (also termed malignant poroma, eccrine porocarcinoma, and malignant eccrine poroma) is a rare form of skin cancer that develops in eccrine sweat glands, i.e. the body's widely distributed major type of sweat glands, as opposed to the apocrine sweat glands which are located primarily in the armpits and perineal area. This cancer typically develops in individuals as a single cutaneous tumor in the intraepidermal spiral part (termed the acrosyringium) of these sweat glands' ducts (i.e. channels) at or near to where they open on the skin's surface. PCA tumors are classified as one form of the cutaneous adnexal tumors; in a study of 2,205 cases, PCA was the most common (11.8%) form of these tumors. Porocarcinomas are malignant counterparts to the far more common benign tumors of the eccrine sweat gland's acrosyringium, i.e. poromas. As currently viewed, there are 4 poroma variants based on their predominant cell types and extent of the their tumor tissues presence in the epidermis and dermis: 1) Hidroacanthoma simplexe poromas are confined to the epidermis, i.e. uppermost layer of the skin. 2) Dermal duct poromas are confined to the dermis, i.e. layer of skin between the epidermis and subcutaneous tissues. 3) Hidradenomas have recently been sub-classified into two groups; 95% are termed clear cell hidradenomas and have features suggesting that they derive from apocrine sweat glands while the remaining 5% are termed poroid hidradenomas and have features suggesting that they derive from eccrine sweat glands. And 4) eccrine poromas are eccrine sweat gland tumors that consist of three cell types (see the histopathology section of Poromas) and are primarily located in the epidermis and superficial dermis. Poromas may have 2 or more of these variants in the same tumor tissue and the variants typically have histopathology findings that are not clearly distinguishable from each other. PCA tumors may arise from one of these longstanding poromas (in one study this occurred in 18% of cases) but more commonly appear to develop independently of any precursor poroma. PCA are locally invasive tumors that have been treated by surgical resection but often recur at the site of their surgical removal and metastasize to distant tissues before or after their removal. Repeatedly recurrent, unresectable, and metastatic PCA have been treated with chemotherapy and/or radiotherapy. However, metastatic PCA has responded poorly to these treatments and carries a poor prognosis. Because of their rarity and lack of distinct clinical features and variable physical and microscopic histological appearances, the diagnosis of porocarcinomas is often challenging. PCA has commonly been either mis-diagnosed or over-diagnosed. Under-diagnosis may have been responsible for a recent study conducted in a United Kingdom single center that reported that the number of PCA cases had increased 3-fold over the previous 4 years and was expected to rapidly rise further during the next decade. (en) |
| dbo:complications | Invasion of nearby tissues, recurrence after surgical removal, metastases |
| dbo:medicalSpecialty | dbr:Dermatology dbr:Surgery dbr:Oncology |
| dbo:symptom | dbr:Eccrine_sweat_gland |
| dbo:synonym | malignant poroma, eccrine porocarcinoma, malignant eccrine poroma |
| dbo:thumbnail | wiki-commons:Special:FilePath/Porocarcinoma_-_alt_--_low_mag.jpg?width=300 |
| dbo:wikiPageID | 23150050 (xsd:integer) |
| dbo:wikiPageLength | 32996 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1123345130 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Carboplatin dbr:Carcinoembryonic_antigen dbr:Amelanotic_melanoma dbr:Bcl-2 dbr:Sarcoidosis dbr:Endoplasmic_reticulum_membrane_protein_complex dbr:Epidermis dbr:Epithelial_cell_adhesion_molecule dbr:Epithelium dbr:Mutation dbr:Metaplasia dbr:C-Kit dbr:Pembrolizumab dbr:Perineum dbr:Retinoblastoma dbr:Cytokeratin dbr:Cytoplasm dbr:Dermatology dbr:Dermis dbr:Interleukin_2 dbr:P53 dbr:Nuclear_protein_in_testis_gene dbr:Transcription_coregulator dbr:Nucleoli dbr:Medical_ultrasound dbr:Medulloblastoma dbr:S100_protein dbr:Poroma dbr:Chronic_lymphocytic_leukemia dbr:Cisplatin dbr:TP53 dbr:BerEp4 dbr:Lymph_node dbr:Lymphadenectomy dbr:MUC1 dbr:Magnetic_resonance_imaging dbr:Clear_cell dbr:Deletion_(genetics) dbr:Keratin_20 dbr:Keratin_7 dbr:Keratinocyte dbr:Basal_cell_carcinoma dbr:Pernicious_anemia dbr:Surgery dbr:Tumor_suppressor_gene dbr:Microcystic_adnexal_carcinoma dbr:Microphthalmia-associated_transcription_factor dbr:Adjuvant_therapy dbr:Transcription_factors dbr:HRAS dbr:Eccrine_sweat_glands dbr:Karyotype dbr:Locus_(genetics) dbr:3T3_cells dbr:Fibroma dbr:Paclitaxel dbr:Paget's_disease_of_the_breast dbr:Cell_junction dbr:Cell_nucleus dbr:Cell_signaling dbr:Chromosomal_inversion dbr:Chromosomal_translocation dbr:Chromosome_11 dbr:Chromosome_15 dbr:Hippo_signaling_pathway dbr:Histopathology dbr:Ki-67_(protein) dbr:Epithelial_membrane_antigen dbr:Reporter_gene dbr:HIV/AIDS dbr:Adriamycin dbr:Isotretinoin dbr:Histological dbr:AE1/AE3 dbc:Epidermal_nevi,_neoplasms,_and_cysts dbc:Rare_cancers dbr:Chemotherapy dbr:Superficial_spreading_melanoma dbr:Eccrine_sweat_gland dbr:Hidradenocarcinoma dbr:Hidradenoma dbr:TEAD1 dbr:TEAD2 dbr:TEAD3 dbr:TEAD4 dbr:Transcript dbr:Mitosis dbr:Diphenylcyclopropenone dbr:Docetaxel dbr:Apocrine_sweat_glands dbr:CD43 dbr:CDKN2A dbr:Positron_emission_tomography–computed_tomography dbr:Fibroblast dbr:Cytokeratin_19 dbr:Cytokeratin_20 dbr:Cytokeratin_5 dbr:Cytokeratin_6 dbr:Metastatic_adenocarcinoma dbr:Immunotherapy dbr:Interferon_alfa dbr:Necrosis dbr:Nevus dbr:Oncology dbr:Radiation_therapy dbr:Radiotherapy dbr:Sebaceous_cyst dbr:Seborrheic_keratosis dbr:X-ray dbr:Xeroderma_pigmentosum dbr:Merkel_cell_carcinoma dbr:Synaptophysin dbr:Sentinel_lymph_node dbr:Verruca_vulgaris dbr:Nevus_sebaceous dbr:Extramammary_Paget's_disease dbr:Immunoassay dbr:Immunohistochemistry dbr:Immunosuppression dbr:Lymphatic_vessel dbr:Lymphedema dbr:Pyogenic_granuloma dbr:Topical_medication dbr:Periodic_acid–Schiff_stain dbr:MAML2 dbr:Wide_local_excision dbr:YAP1 dbr:TP63 dbr:Hodgkin's_disease dbr:Squamous_cell_carcinoma dbr:Epidermal dbr:Prostate_specific_antigen dbr:Prostatic_specific_acid_phosphatase dbr:Proto-oncogene dbr:Squamous_cell dbr:GCDFP15 dbr:Mitoses dbr:Surgical_resection dbr:RB1 dbr:Retroperitoneum dbr:5-fluorouracil dbr:Nevi dbr:NIH-3T3 dbr:Mohs_micrographic_surgery dbr:CK20 dbr:Hematoxylin_and_eosin dbr:Mucous_cell dbr:Spindle_cell dbr:Squamous_cell_carcinomas dbr:TTF-1 dbr:Xeroderma_pigmentosa dbr:File:Porocarcinoma_-_alt_--_low_mag.jpg |
| dbp:causes | Unknown (en) |
| dbp:complications | Invasion of nearby tissues, recurrence after surgical removal, metastases (en) |
| dbp:name | Porocarcinoma (en) |
| dbp:prognosis | Metastatic porcarcinomas often have a poor prognosis (en) |
| dbp:specialty | dbr:Dermatology dbr:Surgery dbr:Oncology |
| dbp:symptoms | Superficial tumor of an eccrine sweat gland virtually anywhere on the skin (en) |
| dbp:synonym | malignant poroma, eccrine porocarcinoma, malignant eccrine poroma (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_medical_condition_(new) dbt:Reflist |
| dcterms:subject | dbc:Epidermal_nevi,_neoplasms,_and_cysts dbc:Rare_cancers |
| rdf:type | owl:Thing wikidata:Q12136 dbo:Disease |
| rdfs:comment | Das Porokarzinom (lateinisch ‚porus‘ aus altgriechisch ‚πὀρος‘, poros, Öffnung, Loch, Pore) ist ein seltener, maligner, vom intraepidermalen Teil des ekkrinen Schweißdrüsenausführungsganges ausgehender, infiltrierend wachsender Tumor. Charakteristisch ist das retrograde Einwachsen in die Epidermis. Manchmal entstehen Porokarzinome auch durch Entartung gutartiger Schweißdrüsentumore. (de) Porocarcinoma (PCA) (also termed malignant poroma, eccrine porocarcinoma, and malignant eccrine poroma) is a rare form of skin cancer that develops in eccrine sweat glands, i.e. the body's widely distributed major type of sweat glands, as opposed to the apocrine sweat glands which are located primarily in the armpits and perineal area. This cancer typically develops in individuals as a single cutaneous tumor in the intraepidermal spiral part (termed the acrosyringium) of these sweat glands' ducts (i.e. channels) at or near to where they open on the skin's surface. PCA tumors are classified as one form of the cutaneous adnexal tumors; in a study of 2,205 cases, PCA was the most common (11.8%) form of these tumors. (en) |
| rdfs:label | Porokarzinom (de) Porocarcinoma (en) |
| owl:sameAs | wikidata:Porocarcinoma dbpedia-de:Porocarcinoma https://global.dbpedia.org/id/nstK |
| prov:wasDerivedFrom | wikipedia-en:Porocarcinoma?oldid=1123345130&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Porocarcinoma_-_alt_--_low_mag.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Porocarcinoma |
| foaf:name | Porocarcinoma (en) |
| is dbo:wikiPageWikiLink of | dbr:Poroma dbr:Skin_cancer dbr:Acrospiroma dbr:Sweat_gland dbr:List_of_skin_conditions |
| is foaf:primaryTopic of | wikipedia-en:Porocarcinoma |
