| dbo:abstract |
Generalmente, en la progresión al cáncer, se silencian o activan cientos de genes. Aunque el silenciamiento de algunos genes en los cánceres ocurre por mutación, una gran proporción del silenciamiento de genes cancerígenos es el resultado de una alteración de la metilación del ADN. La metilación del ADN que causa el silenciamiento en el cáncer ocurre típicamente en múltiples en las que están presentes en los promotores de genes que codifican proteínas. Las expresiones alteradas de microARN también silencian o activan muchos genes en progresión al cáncer (ver microARN en cáncer). La expresión de microARN alterada ocurre a través de hiper/hipometilación de en en promotores que controlan la transcripción de microARN. El silenciamiento de los genes de reparación del ADN mediante la metilación de las islas CpG en sus promotores parece ser especialmente importante en la progresión al cáncer. (es) Generally, in progression to cancer, hundreds of genes are silenced or activated. Although silencing of some genes in cancers occurs by mutation, a large proportion of carcinogenic gene silencing is a result of altered DNA methylation (see DNA methylation in cancer). DNA methylation causing silencing in cancer typically occurs at multiple CpG sites in the CpG islands that are present in the promoters of protein coding genes. Altered expressions of microRNAs also silence or activate many genes in progression to cancer (see microRNAs in cancer). Altered microRNA expression occurs through hyper/hypo-methylation of CpG sites in CpG islands in promoters controlling transcription of the microRNAs. Silencing of DNA repair genes through methylation of CpG islands in their promoters appears to be especially important in progression to cancer (see methylation of DNA repair genes in cancer). (en) |
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dbr:Cancer dbr:5-methylcytosine dbr:Pyrimidine dbr:Epigenetics dbr:FANCB dbr:Messenger_RNA dbr:MicroRNA dbr:Mutation dbr:Non-small-cell_lung_carcinoma dbr:Nucleotide dbr:Neoplasm dbr:DNA dbr:DNA_methylation dbr:DNA_methylation_in_cancer dbr:DNA_repair dbr:DNA_replication dbr:Post-transcriptional_regulation dbc:DNA dbc:Epigenetics dbr:Gene_expression dbr:Genetic_hitchhiking dbr:MLH1 dbr:LIG4 dbr:Somatic_evolution_in_cancer dbc:Medical_regulation dbr:Microhomology-mediated_end_joining dbr:O-6-methylguanine-DNA_methyltransferase dbc:Non-coding_RNA dbr:Transcription_(genetics) dbr:Transcriptional_regulation dbr:Head_and_neck_cancer dbc:Gene_expression dbr:Cytosine dbr:Base_pair dbr:Directionality_(molecular_biology) dbr:Promoter_(genetics) dbr:Guanine dbr:CpG_site dbr:ERCC1 dbc:Cancer_epigenetics dbr:DNA_sequence dbr:FEN1 dbr:Ataxia_telangiectasia_mutated dbr:Cancer_epigenetics dbr:Gene_set_enrichment dbr:Eukaryotic_transcription dbr:Noncoding_DNA dbr:NEIL1 dbr:PARP1 |
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dbc:DNA dbc:Epigenetics dbc:Medical_regulation dbc:Non-coding_RNA dbc:Gene_expression dbc:Cancer_epigenetics |
| rdfs:comment |
Generalmente, en la progresión al cáncer, se silencian o activan cientos de genes. Aunque el silenciamiento de algunos genes en los cánceres ocurre por mutación, una gran proporción del silenciamiento de genes cancerígenos es el resultado de una alteración de la metilación del ADN. La metilación del ADN que causa el silenciamiento en el cáncer ocurre típicamente en múltiples en las que están presentes en los promotores de genes que codifican proteínas. (es) Generally, in progression to cancer, hundreds of genes are silenced or activated. Although silencing of some genes in cancers occurs by mutation, a large proportion of carcinogenic gene silencing is a result of altered DNA methylation (see DNA methylation in cancer). DNA methylation causing silencing in cancer typically occurs at multiple CpG sites in the CpG islands that are present in the promoters of protein coding genes. (en) |
| rdfs:label |
Regulación de la transcripción en cáncer (es) Regulation of transcription in cancer (en) |
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wikidata:Regulation of transcription in cancer dbpedia-es:Regulation of transcription in cancer dbpedia-tr:Regulation of transcription in cancer https://global.dbpedia.org/id/2cqgR |
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wikipedia-en:Regulation_of_transcription_in_cancer?oldid=1119685600&ns=0 |
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wikipedia-en:Regulation_of_transcription_in_cancer |
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dbr:DNA_methylation dbr:DNA_methylation_in_cancer dbr:Downregulation_and_upregulation dbr:Inflammation dbr:Gene_expression dbr:Transcription_(biology) dbr:Transcriptional_regulation dbr:HBx dbr:Promoter_(genetics) dbr:Regulation_of_gene_expression dbr:Diffuse_large_B-cell_lymphoma dbr:Dinah_Singer dbr:Cancer_epigenetics dbr:Eukaryotic_transcription dbr:Malignant_transformation dbr:NEDD8 dbr:T_cell/histiocyte-rich_large_B-cell_lymphoma |
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