Reptin (original) (raw)
Reptin is a tumor repressor protein that is a member of the ATPases Associated with various cellular Activities (AAA+) helicase family and regulates KAI1. of reptin alters the repressive function of reptin and its association with HDAC1. The sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential. Reptin was reported in 2010 to be a good marker for metastasis. Another name for reptin, RuvB-like 2 (RUVBL2 or RVL2) comes from its similarity to RuvB, an ATP-dependent helicase found in bacteria. Reptin is highly conserved, being found in yeast, drosophila, and humans. It presents itself as a member of a number of different protein complexes, most of which function in chromatin modification, including PRC1, TIP60/NuA4 and INO80. Hence, it also has
| Property | Value |
|---|---|
| dbo:abstract | Reptin is a tumor repressor protein that is a member of the ATPases Associated with various cellular Activities (AAA+) helicase family and regulates KAI1. of reptin alters the repressive function of reptin and its association with HDAC1. The sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential. Reptin was reported in 2010 to be a good marker for metastasis. Another name for reptin, RuvB-like 2 (RUVBL2 or RVL2) comes from its similarity to RuvB, an ATP-dependent helicase found in bacteria. Reptin is highly conserved, being found in yeast, drosophila, and humans. It presents itself as a member of a number of different protein complexes, most of which function in chromatin modification, including PRC1, TIP60/NuA4 and INO80. Hence, it also has the names INO80J, TIP48, and TIP49B. In the majority of its functions, reptin is paired with a very similar protein, pontin (RUVBL1). (en) |
| dbo:wikiPageID | 28000223 (xsd:integer) |
| dbo:wikiPageLength | 14992 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1044675916 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Beta-catenin dbr:DNA_repair dbr:DNA_replication dbr:Dynein dbr:Dyskerin dbr:Saccharomyces_cerevisiae dbr:P53 dbc:Enzymes dbr:Polycomb-group_proteins dbr:RNA_polymerase_II dbr:Chlamydomonas_reinhardtii dbr:Zebrafish dbr:Transcription_(genetics) dbr:WNT1 dbr:HDAC1 dbr:Helicase dbr:Drosophila dbr:NuA4_histone_acetyltransferase_complex dbr:Chromatin dbr:Cilium dbr:Histone_acetylation_and_deacetylation dbr:Protein dbr:Small_nucleolar_RNA dbr:AAA_proteins dbr:AGR2 dbr:Homologous_recombination dbr:Hox_gene dbr:Hsp90 dbr:HINT1 dbr:Metastasis dbr:Cancer_cell dbr:Telomerase_reverse_transcriptase dbr:Flagellum dbr:Telomerase dbr:PRC1 dbr:KAI1 dbr:Desumoylation |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:Reflist |
| dct:subject | dbc:Enzymes |
| gold:hypernym | dbr:Protein |
| rdf:type | yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:Protein yago:Substance100020090 yago:WikicatDrugs |
| rdfs:comment | Reptin is a tumor repressor protein that is a member of the ATPases Associated with various cellular Activities (AAA+) helicase family and regulates KAI1. of reptin alters the repressive function of reptin and its association with HDAC1. The sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential. Reptin was reported in 2010 to be a good marker for metastasis. Another name for reptin, RuvB-like 2 (RUVBL2 or RVL2) comes from its similarity to RuvB, an ATP-dependent helicase found in bacteria. Reptin is highly conserved, being found in yeast, drosophila, and humans. It presents itself as a member of a number of different protein complexes, most of which function in chromatin modification, including PRC1, TIP60/NuA4 and INO80. Hence, it also has (en) |
| rdfs:label | Reptin (en) |
| owl:sameAs | freebase:Reptin yago-res:Reptin wikidata:Reptin https://global.dbpedia.org/id/8L7gG |
| prov:wasDerivedFrom | wikipedia-en:Reptin?oldid=1044675916&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Reptin |
| is dbo:wikiPageWikiLink of | dbr:AGR2 |
| is foaf:primaryTopic of | wikipedia-en:Reptin |