Rho-associated protein kinase (original) (raw)
Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.
| Property | Value |
|---|---|
| dbo:abstract | Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. ROCKs (ROCK1 and ROCK2) occur in mammals (human, rat, mouse, cow), zebrafish, Xenopus, invertebrates (C. elegans, mosquito, Drosophila) and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, a coiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. Rat ROCKs were discovered as the first effectors of Rho and they induce the formation of stress fibers and focal adhesions by phosphorylating MLC (myosin light chain).Due to this phosphorylation, the actin binding of myosin II and, thus, the contractility increases. Two mouse ROCK isoforms ROCK1 and ROCK2 have been identified. ROCK1 is mainly expressed in the lung, liver, spleen, kidney and testis. However, ROCK2 is distributed mostly in the brain and heart. Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells. (en) La proteina chinasi associata a Rho (Rho-associated protein kinase, ROCK) è una chinasi che appartiene alla famiglia AGC (PKA/PKG/PKC) delle serina-treonina chinasi. È coinvolta principalmente nella regolazione della forma e del movimento delle cellule agendo sul loro citoscheletro. Le chinasi ROCKs (ROCK1 and ROCK2) sono presenti nei: * mammiferi (umano, ratto, topo, mucca); * danio rerio (pesce zebra); * xenopus; * invertebrati (C. elegans, mosquito, drosophila); * polli. La proteina umana ROCK1 ha una massa molecolare di 158 kDa ed è il principale effettore a valle a seguito dell'azione della piccola GTPasi RhoA. La proteina ROCK dei mammiferi è composta da: 1. * un dominio chinasico; 2. * una regione coiled-coil; 3. * un dominio PH (Pleckstrin homology) che riduce l'attività chinasica delle ROCKs (per mezzo di una piega intramolecolare autoinibitoria se non è presente RhoA-GTP). Nel ratto Le ROCKs furono scoperte come i primi effettori di Rho; esse inducono la formazione delle stress fibers e delle fosforilando la MLC (myosin light chain, catena leggera della miosina). A causa di questa fosforilazione, il legame dell'actina alla miosina II aumenta in numero: pertanto aumenta la contrattilità. Nel topo sono state identificate due isoforme di ROCK: ROCK1 e ROCK2. ROCK1 è espressa principalmente nei polmoni, fegato, milza, reni e testicolo; ROCK2 è espressa prevalentemente nel cervello e nel cuore. (it) |
| dbo:arm | p |
| dbo:band | 24 |
| dbo:ecNumber | 2.7.11.1 |
| dbo:entrezgene | 6093 9475 579202 |
| dbo:hgncid | 10251 10252 |
| dbo:locusSupplementaryData | -q32 |
| dbo:omim | 601702 (xsd:integer) 604002 (xsd:integer) |
| dbo:refseq | NM_004850 NM_005406 |
| dbo:symbol | ROCK1 ROCK2 Rho-associated protein kinase Rho-associated, coiled-coil-containing protein kinase |
| dbo:thumbnail | wiki-commons:Special:FilePath/3d9v_bio_r_500.jpg?width=300 |
| dbo:uniprot | O75116 Q13464 |
| dbo:wikiPageID | 27388475 (xsd:integer) |
| dbo:wikiPageLength | 19012 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1124804311 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Caenorhabditis_elegans dbr:Cancer dbr:RhoA dbr:Cytoskeleton dbr:Intramolecular_force dbr:Spleen dbc:EC_2.7.11 dbc:Protein_families dbr:Cofilin dbr:Brain dbr:Myosin dbr:Contractility dbr:Apoptosis dbr:Arachidonic_acid dbr:Liver dbr:Statin dbr:PTEN_(gene) dbr:Pleckstrin_homology dbr:Protein_kinase_C dbr:Actin dbr:Activator_(genetics) dbr:Cell_(biology) dbr:Centrioles dbr:Tumor dbr:Drug_resistance dbr:GTPase dbr:Amino_acid dbr:Amyotrophic_lateral_sclerosis dbr:Cytokinesis dbr:Drosophila dbr:Alzheimer's_disease dbr:Parkinson's_disease dbr:Cardiovascular_disease dbr:Cell_migration dbr:Kinase dbr:Focal_adhesions dbr:Rho_family_of_GTPases dbr:Heart dbr:Atomic_mass_unit dbr:ATPase dbc:Cell_cycle dbr:Kidney dbr:Homology_(biology) dbr:Growth_cone dbr:Insulin dbr:Integrin dbr:RKI-1447 dbr:Sequence_motif dbr:Serine/threonine-specific_protein_kinase dbr:Xenopus dbr:Lung dbr:ROCK1 dbr:Neurite dbr:Cdc42 dbr:Myotonin-protein_kinase dbr:Myosin_II dbr:Molecular_mass dbr:Phosphatase dbr:Phosphorylation dbr:Rho_kinase_inhibitor dbr:Stress_fiber dbr:ROCK2 dbr:LIM_kinase dbr:Testis dbr:PH_domain dbr:Coiled-coil dbr:Membrane_blebbing dbr:Oligomerization dbr:File:ROCK_protein_function.svg |
| dbp:altsymbols | Rho-associated, coiled-coil-containing protein kinase (en) |
| dbp:arm | p (en) |
| dbp:band | 24 (xsd:integer) |
| dbp:caption | Crystal structure of human ROCK I (en) |
| dbp:ecnumber | 2.700000 (xsd:double) |
| dbp:entrezgene | 6093 (xsd:integer) 9475 (xsd:integer) 579202 (xsd:integer) |
| dbp:hgncid | 10251 (xsd:integer) 10252 (xsd:integer) |
| dbp:locussupplementarydata | -q32 (en) |
| dbp:name | ROCK (en) Rho-associated, coiled-coil-containing protein kinase 1 (en) Rho-associated, coiled-coil-containing protein kinase 2 (en) |
| dbp:omim | 601702 (xsd:integer) 604002 (xsd:integer) |
| dbp:refseq | NM_004850 (en) NM_005406 (en) |
| dbp:symbol | dbr:ROCK1 ROCK2 (en) Rho-associated protein kinase (en) |
| dbp:uniprot | O75116 (en) Q13464 (en) |
| dbp:wikiPageUsesTemplate | dbt:Clear dbt:Distinguish dbt:Expand_section dbt:Kinases dbt:Reflist dbt:See dbt:Serine/threonine-specific_protein_kinases dbt:Infobox_protein dbt:Intracellular_signaling_peptides_and_proteins |
| dcterms:subject | dbc:EC_2.7.11 dbc:Protein_families dbc:Cell_cycle |
| gold:hypernym | dbr:Kinase |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatAnimalGenes yago:WikicatAnimalProteins yago:Abstraction100002137 yago:Arrangement107938773 yago:Chemical114806838 yago:Compound114818238 yago:Gene105436752 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:Ordering108456993 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Sequence108459252 yago:Series108457976 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells. (en) La proteina chinasi associata a Rho (Rho-associated protein kinase, ROCK) è una chinasi che appartiene alla famiglia AGC (PKA/PKG/PKC) delle serina-treonina chinasi. È coinvolta principalmente nella regolazione della forma e del movimento delle cellule agendo sul loro citoscheletro. Le chinasi ROCKs (ROCK1 and ROCK2) sono presenti nei: * mammiferi (umano, ratto, topo, mucca); * danio rerio (pesce zebra); * xenopus; * invertebrati (C. elegans, mosquito, drosophila); * polli. La proteina ROCK dei mammiferi è composta da: (it) |
| rdfs:label | Proteina chinasi associata a Rho (it) Rho-associated protein kinase (en) |
| owl:differentFrom | dbr:Rho_Chi |
| owl:sameAs | freebase:Rho-associated protein kinase yago-res:Rho-associated protein kinase wikidata:Rho-associated protein kinase dbpedia-et:Rho-associated protein kinase dbpedia-it:Rho-associated protein kinase dbpedia-sh:Rho-associated protein kinase dbpedia-sr:Rho-associated protein kinase https://global.dbpedia.org/id/2KdLZ |
| prov:wasDerivedFrom | wikipedia-en:Rho-associated_protein_kinase?oldid=1124804311&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/3d9v_bio_r_500.jpg wiki-commons:Special:FilePath/ROCK_protein_function.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Rho-associated_protein_kinase |
| foaf:name | ROCK (en) Rho-associated, coiled-coil-containing protein kinase 1 (en) Rho-associated, coiled-coil-containing protein kinase 2 (en) |
| is dbo:wikiPageRedirects of | dbr:ROCK_inhibitor dbr:Rho-associated_kinase dbr:Rho-kinase dbr:Rho_kinase |
| is dbo:wikiPageWikiLink of | dbr:Nerve_conduction_velocity dbr:Pseudopodia dbr:Coronary_vasospasm dbr:MiR-138 dbr:Calponin_1 dbr:Chondroitin_sulfate_proteoglycan dbr:Statin dbr:Embryoid_body dbr:G_protein-coupled_receptor dbr:Mir-10_microRNA_precursor_family dbr:Myosin_light-chain_kinase dbr:Fasudil dbr:Forsythoside_B dbr:ROCK dbr:Rif_(GTPase) dbr:AAMP_(gene) dbr:Guillain–Barré_syndrome dbr:Asymmetric_cell_division dbr:Hyaluronan-mediated_motility_receptor dbr:Kadmon_Corporation dbr:Coagulation_factor_II_receptor dbr:Mary_Kay_Lobo dbr:Citron_kinase dbr:Ibuprofen dbr:Y-27632 dbr:Myelin-associated_glycoprotein dbr:Wnt_signaling_pathway dbr:MYH10 dbr:Myosin-light-chain_phosphatase dbr:Rho_kinase_inhibitor dbr:Transforming_protein_RhoA dbr:ROCK_inhibitor dbr:Rho-associated_kinase dbr:Rho-kinase dbr:Rho_kinase |
| is foaf:primaryTopic of | wikipedia-en:Rho-associated_protein_kinase |
