Ribosomal s6 kinase (original) (raw)
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.
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| dbo:abstract | In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2. (en) Kinase ribosomal s6 (bahasa Inggris: ribosomal s6 kinase, A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; protein kinase (phosphorylating); protein kinase A; protein kinase CK2; protein kinase p58; protein phosphokinase; protein serine kinase; protein serine-threonine kinase; Serine/threonine-protein kinase B-raf, proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, protein-aspartyl kinase; protein-cysteine kinase; protein-serine kinase; Prp4 protein kinase; Raf kinase; Raf-1; ribosomal protein S6 kinase II; ribosomal S6 protein kinase; serine kinase; serine protein kinase; serine-specific protein kinase; serine(threonine) protein kinase; serine/threonine protein kinase; STK32; T-antigen kinase; threonine-specific protein kinase; twitchin kinase; type-2 casein kinase; βIIPKC; ε PKC; Wee 1-like kinase; Wee-kinase; WEE1Hu, Rsk, EC 2.7.11.1) adalah yang mempercepat reaksi fosforilasi pada residu serina/treonina dan teraktivasi melalui lintasan MAPK/ERK. Terdapat dua jenis Rsk, p90rsk atau MAPK-activated protein kinase-1 (MAPKAP-K1) dan p70rsk atau S6-H1 Kinase atau S6K. Manusia memiliki 4 ekspresi Rsk, yaitu RSK-1, RSK-2, RSK-3, RSK-4. Rsk banyak dijumpai pada inti sel, sitoplasma dan membran plasma, terutama pada sel otak dan testis. Pada sistem saraf, Rsk diketahui mempercepat fosforilasi pada protein pro-apoptotik pada serina residu 112, baik in vitro maupun in vivo. Fosforilasi ini mencegah apoptosis neuron yang dimediasi oleh BAD. Katalisasi Rsk juga terjadi pada faktor transkripsi pada serina 133. Fosforilasi CREB berfungsi guna kelangsungan hidup sel, dan terhambatnya fosforilasi ini akan menginduksi apoptosis. RSK-2, ketika teraktivasi, akan bermigrasi menuju ke dalam inti sel dan menkatalis berbagai protein inti seperti , , histon, CREB, dan p53. Pada hewan tikus, terhambatnya RSK-2 meredakan terbentuknya yang bergantung pada c-Fos. Sedangkan senyawa yang merupakan ekstrak tumbuhan tropis dapat menghambat aktivitas RSK-2 dan menekan proliferasi sel kanker payudara dan sel kanker prostat . Mutasi genetik RSK-2 akan menyebabkan penyimpangan pada lintasan MAPK/Rsk hingga menginduksi . (in) Kinazy rybosomalne S6 (rsk) – rodzina kinaz białkowych, zaangażowanych w transdukcję sygnału w komórce. Wyróżnia się dwie podrodziny rsk, p90rsk, znane też jako MAPK-activated protein kinase-1 (MAPKAP-K1), i p70rsk, określane również jako kinazy S6-H1 lub po prostu kinazy S6. U człowieka występują trzy warianty p90rsk, oznaczane rsk 1-3. Rsk są kinazami serynowo-treoninowymi, aktywowanymi przez kinazy szlaku MAPK/ERK. Znane są dwa homologi kinazy S6 u ssaków: S6K1 i S6K2. Rsk zostały zidentyfikowane po raz pierwszy w jajach Xenopus laevis przez Eriksona i Mallera w 1985 roku. (pl) |
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| rdfs:comment | In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2. (en) Kinazy rybosomalne S6 (rsk) – rodzina kinaz białkowych, zaangażowanych w transdukcję sygnału w komórce. Wyróżnia się dwie podrodziny rsk, p90rsk, znane też jako MAPK-activated protein kinase-1 (MAPKAP-K1), i p70rsk, określane również jako kinazy S6-H1 lub po prostu kinazy S6. U człowieka występują trzy warianty p90rsk, oznaczane rsk 1-3. Rsk są kinazami serynowo-treoninowymi, aktywowanymi przez kinazy szlaku MAPK/ERK. Znane są dwa homologi kinazy S6 u ssaków: S6K1 i S6K2. Rsk zostały zidentyfikowane po raz pierwszy w jajach Xenopus laevis przez Eriksona i Mallera w 1985 roku. (pl) Kinase ribosomal s6 (bahasa Inggris: ribosomal s6 kinase, A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; (in) |
| rdfs:label | Ribosomal s6 kinase (in) Kinazy rybosomalne s6 (pl) Ribosomal s6 kinase (en) |
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