| dbo:abstract |
SAE2 is a gene in budding yeast, coding for the protein Sae2, which is involved in DNA repair. Sae2 is a part of the homologous recombination process in response to double-strand breaks. It is best characterized in the yeast model organism Saccharomyces cerevisiae. Homologous genes in other organisms include in fission yeast, Com1 in plants, and in higher eukaryotes including humans. Sae2 and its homologs have relatively long low-complexity regions in their primary sequences and appear to have large intrinsically unstructured regions. Sae2 likely forms tetramers through coiled-coil sequences. Proteins of this family are DNA-binding proteins and are involved in DNA end resection and bridging at double-strand breaks. Sae2 has been reported to have endonuclease activity, though it has no bioinformatically recognizable nuclease sequence and reports of this activity are not consistent in the literature. (en) Sae2 (サエツー）は、ハーバード大学のNacy Kleckner教授らのグループによって発見された出芽酵母の遺伝子である。おなじ遺伝子はクライン博士らによっても同時期に発見され、Com1 (コムワン)とも呼ばれる。 (ja) |
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14798303 (xsd:integer) |
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3798 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink |
dbr:Endonuclease dbr:DNA-binding_protein dbr:DNA_end_resection dbr:DNA_repair dbr:Saccharomyces_cerevisiae dbr:Nuclease dbr:Low_complexity_regions_in_proteins dbr:Gene dbr:Com1 dbr:Eukaryote dbr:Protein dbr:UBA2 dbc:Saccharomyces_cerevisiae_genes dbr:Bioinformatics dbr:Homologous_recombination dbr:Homology_(biology) dbr:Yeast dbr:Model_organism dbr:Intrinsically_unstructured_protein dbr:Primary_sequence dbr:Tetramer dbr:Fission_yeast dbr:Double-strand_break dbr:Coiled-coil dbr:Budding_yeast dbr:CtIP dbr:Ctp1 |
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dbt:Distinguish dbt:Reflist |
| dcterms:subject |
dbc:Saccharomyces_cerevisiae_genes |
| rdf:type |
owl:Thing |
| rdfs:comment |
Sae2 (サエツー）は、ハーバード大学のNacy Kleckner教授らのグループによって発見された出芽酵母の遺伝子である。おなじ遺伝子はクライン博士らによっても同時期に発見され、Com1 (コムワン)とも呼ばれる。 (ja) SAE2 is a gene in budding yeast, coding for the protein Sae2, which is involved in DNA repair. Sae2 is a part of the homologous recombination process in response to double-strand breaks. It is best characterized in the yeast model organism Saccharomyces cerevisiae. Homologous genes in other organisms include in fission yeast, Com1 in plants, and in higher eukaryotes including humans. (en) |
| rdfs:label |
Sae2 (ja) SAE2 (yeast) (en) |
| owl:sameAs |
wikidata:SAE2 (yeast) dbpedia-ja:SAE2 (yeast) https://global.dbpedia.org/id/n99U |
| prov:wasDerivedFrom |
wikipedia-en:SAE2_(yeast)?oldid=1110787552&ns=0 |
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wikipedia-en:SAE2_(yeast) |
| is dbo:wikiPageWikiLink of |
dbr:DNA_end_resection dbr:SAE2 dbr:Homologous_recombination |
| is foaf:primaryTopic of |
wikipedia-en:SAE2_(yeast) |