| dbo:abstract |
SH2 doména (Src-homology 2 domain) je strukturní doména vyskytující se v různé míře u všech eukaryotických organismů; je typická tím, že se váže na fosforylovaný tyrosin . Je součástí celé řady především signálních bílkovin v buňce, jako jsou: Lck, , , Src, , STAT, či PI3K. SH2 rozeznává strukturní motiv pY-XX-Z, tzn. váže se na fosfotyrosin a další aminokyselinu vzdálenou tři pozice od fosfotyrosinu. (cs) Eine SH2-Domäne ist eine Proteindomäne, die spezifische Proteininteraktionen vermittelt. Die Abkürzung SH2 steht für Src-homology 2 (abgeleitet von der Proteinkinase c-Src, in der die Domäne das erste Mal beschrieben wurde; vgl. SH3-Domäne). Die Region ist ca. 100 Aminosäuren lang und erkennt insbesondere Peptide mit phosphoryliertem Tyrosin (Phosphotyrosin). SH2-Domänen sind an vielen Proteinkomplexen beteiligt, insbesondere bei Gerüstproteinen. Zudem spielen SH2-Domänen eine wichtige Rolle bei einigen Signalwegen. (de) El dominio SH2 (del inglés Src Homology 2) es un dominio de proteínas estructuralmente muy conservado en la oncoproteína y en muchas otras proteínas de transducción de señales intracelulares. (es) The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways. (en) SH2ドメイン（Src homology 2 domain）はおよそ100アミノ酸残基からなるタンパク質ドメインの1つで、がん遺伝子由来のタンパク質SrcとFpsの共通配列として発見された。 同様の構造を持つタンパク質は後にシグナル伝達に関わるタンパク質など、細胞間タンパク質より多数発見された。 (ja) SH2-domänen eller Src Homology 2-domain, efter proteinet som var det första där man identifierade domänen, är en speciell proteindomän som medger inbindning av SH2-bindande domäner. (sv) SH2结构域（英語：Src Homology 2 domain，Src同源2结构域）是癌蛋白以及许多其它细胞内信号转导蛋白上的一个保守的结构域。那些含SH2结构域的蛋白质可以对接到其它蛋白中的磷酸化酪氨酸残基上。SH2结构域往往存在于帮助受体酪氨酸激酶通路信号转导的衔接蛋白中。 (zh) |
| dbo:symbol |
SH2 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/1lkkA_SH2_domain.png?width=300 |
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https://sites.google.com/site/sh2domain/ |
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dbr:BCAR3 dbr:Mouse dbr:Short_linear_motif dbr:VAV3 dbr:SH2D1B dbr:SOCS7 dbr:SOCS1 dbr:Human dbr:Beta_sheet dbr:Signal_transducing_adaptor_protein dbr:GRAP dbr:GRAP2 dbr:GRB10 dbr:GRB14 dbr:SH2D3C dbr:PIK3R1 dbr:PTK6 dbr:SHC3 dbr:RAS_p21_protein_activator_1 dbr:SH3BP2 dbr:STAT5B dbr:TENC1 dbr:SH2D3A dbr:LYN dbr:Animalia dbr:Anthony_Pawson dbr:Chimerin_2 dbr:BLK_(gene) dbr:Metabolic_pathway dbr:Substrate_(biochemistry) dbr:TEC_(gene) dbr:TXK dbr:PTPN6 dbr:CISH_(gene) dbr:Tyrosine dbr:Dissociation_constant dbr:Fusion_protein dbr:Fyn-related_kinase dbr:GRB7 dbr:HCK dbr:HSH2D dbr:DAPP1 dbr:Janus_kinase_2 dbr:Grb2 dbr:Alpha_helix dbc:Peripheral_membrane_proteins dbr:Feline_sarcoma_oncogene dbr:Bioinformatic dbr:Dictyostelium_discoideum dbr:Kinase dbr:Protein_domain dbr:Receptor_tyrosine_kinase dbc:Protein_domains dbr:Intracellular dbr:STAT3 dbr:SH2D4A dbr:ABL2 dbc:Signal_transduction dbr:Lck dbr:Binding_domain dbr:Syk dbr:Signal_transduction dbr:Yeast dbr:PIK3R2 dbr:B-cell_linker dbr:BMX_(gene) dbr:Phosphotyrosine dbr:Phosphotyrosine-binding_domain dbr:Piers_Nash dbr:Src_(gene) dbr:Bruton's_tyrosine_kinase dbr:CRKL dbr:C-src_tyrosine_kinase dbr:CRK_(gene) dbr:Megakaryocyte-associated_tyrosine_kinase dbr:SHB_(gene) dbr:SHC1 dbr:SOCS5 dbr:FER_(gene) dbr:FGR_(gene) dbr:FYN dbr:INPP5D dbr:INPPL1 dbr:ITK_(gene) dbr:Lymphocyte_cytosolic_protein_2 dbr:SH2B3 dbr:NCK1 dbr:NCK2 dbr:SLA2 dbr:TNS4 dbr:Molecular_biology dbr:Protein_engineering dbr:SH2D2A dbr:SOCS2 dbr:STAT1 dbr:YES1 dbr:Protozoa dbr:Phosphorylation dbr:SH2D1A dbr:SH2B1 dbr:Tyrosine_kinase dbr:PIK3R3 dbr:SH2B2 dbr:VAV1 dbr:STAT6 dbr:STAT4 dbr:STAT5A dbr:STAT2 dbr:SOCS6 dbr:PLCG1 dbr:PLCG2 dbr:PTPN11 dbr:SUPT6H dbr:SOCS3 dbr:SOCS4 dbr:TNS1 dbr:VAV2 dbr:ZAP-70 dbr:Phosphorylated dbr:Oncoprotein dbr:Abl_gene dbr:Beta_strand dbr:Src-like-adaptor dbr:Src_homology_2_domain_containing_E dbr:TNS_(gene) dbr:SH2D4B dbr:SH2D5 dbr:SH2D6 dbr:SHC4 dbr:SHD_(gene) dbr:SRMS_(gene) dbr:TNS3 |
| dbp:caption |
Crystallographic structure of the SH2 domain. The structure consists of a large beta sheet flanked by two alpha-helices . (en) |
| dbp:cdd |
cd00173 (en) |
| dbp:interpro |
IPR000980 (en) |
| dbp:pfam |
PF00017 (en) |
| dbp:prosite |
PDOC50001 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:smart |
SH2 (en) |
| dbp:symbol |
SH2 (en) |
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220 (xsd:integer) |
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dbt:Reflist dbt:Short_description dbt:Protein_tertiary_structure dbt:Protein_domains dbt:Pfam_box |
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dbc:Peripheral_membrane_proteins dbc:Protein_domains dbc:Signal_transduction |
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| rdfs:comment |
SH2 doména (Src-homology 2 domain) je strukturní doména vyskytující se v různé míře u všech eukaryotických organismů; je typická tím, že se váže na fosforylovaný tyrosin . Je součástí celé řady především signálních bílkovin v buňce, jako jsou: Lck, , , Src, , STAT, či PI3K. SH2 rozeznává strukturní motiv pY-XX-Z, tzn. váže se na fosfotyrosin a další aminokyselinu vzdálenou tři pozice od fosfotyrosinu. (cs) Eine SH2-Domäne ist eine Proteindomäne, die spezifische Proteininteraktionen vermittelt. Die Abkürzung SH2 steht für Src-homology 2 (abgeleitet von der Proteinkinase c-Src, in der die Domäne das erste Mal beschrieben wurde; vgl. SH3-Domäne). Die Region ist ca. 100 Aminosäuren lang und erkennt insbesondere Peptide mit phosphoryliertem Tyrosin (Phosphotyrosin). SH2-Domänen sind an vielen Proteinkomplexen beteiligt, insbesondere bei Gerüstproteinen. Zudem spielen SH2-Domänen eine wichtige Rolle bei einigen Signalwegen. (de) El dominio SH2 (del inglés Src Homology 2) es un dominio de proteínas estructuralmente muy conservado en la oncoproteína y en muchas otras proteínas de transducción de señales intracelulares. (es) The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways. (en) SH2ドメイン（Src homology 2 domain）はおよそ100アミノ酸残基からなるタンパク質ドメインの1つで、がん遺伝子由来のタンパク質SrcとFpsの共通配列として発見された。 同様の構造を持つタンパク質は後にシグナル伝達に関わるタンパク質など、細胞間タンパク質より多数発見された。 (ja) SH2-domänen eller Src Homology 2-domain, efter proteinet som var det första där man identifierade domänen, är en speciell proteindomän som medger inbindning av SH2-bindande domäner. (sv) SH2结构域（英語：Src Homology 2 domain，Src同源2结构域）是癌蛋白以及许多其它细胞内信号转导蛋白上的一个保守的结构域。那些含SH2结构域的蛋白质可以对接到其它蛋白中的磷酸化酪氨酸残基上。SH2结构域往往存在于帮助受体酪氨酸激酶通路信号转导的衔接蛋白中。 (zh) |
| rdfs:label |
SH2 doména (cs) SH2-Domäne (de) Dominio SH2 (es) SH2ドメイン (ja) SH2 domain (en) SH2-domän (sv) SH2结构域 (zh) |
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freebase:SH2 domain yago-res:SH2 domain wikidata:SH2 domain dbpedia-cs:SH2 domain dbpedia-de:SH2 domain dbpedia-es:SH2 domain dbpedia-fa:SH2 domain dbpedia-gl:SH2 domain dbpedia-ja:SH2 domain dbpedia-mk:SH2 domain dbpedia-sh:SH2 domain dbpedia-sr:SH2 domain dbpedia-sv:SH2 domain dbpedia-zh:SH2 domain https://global.dbpedia.org/id/2L6XM |
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wikipedia-en:SH2_domain?oldid=1121336534&ns=0 |
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