| dbo:abstract |
Slit-Robo is the name of a cell signaling protein complex with many diverse functions including axon guidance and angiogenesis. Slit refers to a secreted protein that is most widely known as a repulsive axon guidance cue, and Robo refers to its transmembrane protein receptor. There are four different Robos and three Slits in vertebrates: Robo1, Robo2, Robo3/Rig-1, and Robo4, and Slit1, Slit2, Slit3. There are three Robos and a single Slit in Drosophila. The corresponding Slit and Robo homologues in C. elegans are Slt and Sax-3, respectively. Slits are characterized by four distinct domains, each containing variable numbers of leucine-rich repeats (LRRs), seven to nine EGF repeats, an ALPS domain (Agrin, Perlecan, Laminin, Slit), and a cysteine knot. Robos are characterized by five Ig-like domains, three fibronectin type III (FNIII) repeats, a transmembrane portion, and an intracellular tail with up to four conserved cytoplasmic motifs: CC0 (a potential site of tyrosine phosphorylation), CC1 (also a potential site of tyrosine phosphorylation and binds P3 domain of netrin-1 receptor DCC), CC2 (polyproline stretch; consensus binding site for Ena/Vasp proteins), and CC3 (polyproline stretch). (en) |
| rdfs:comment |
Slit-Robo is the name of a cell signaling protein complex with many diverse functions including axon guidance and angiogenesis. Slit refers to a secreted protein that is most widely known as a repulsive axon guidance cue, and Robo refers to its transmembrane protein receptor. There are four different Robos and three Slits in vertebrates: Robo1, Robo2, Robo3/Rig-1, and Robo4, and Slit1, Slit2, Slit3. There are three Robos and a single Slit in Drosophila. The corresponding Slit and Robo homologues in C. elegans are Slt and Sax-3, respectively. (en) |
