Acitretin (original) (raw)
أسيتريتين هو مركب من الجيل الثاني . يؤخذ عن طريق الفم، ويستخدم لعلاج الصدفية. وهو مستقلب من الإيتريتينيت الذي توقف استخدامه بسبب ضيق هامشه العلاجي، وطول عمره النصفي.
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| dbo:abstract | أسيتريتين هو مركب من الجيل الثاني . يؤخذ عن طريق الفم، ويستخدم لعلاج الصدفية. وهو مستقلب من الإيتريتينيت الذي توقف استخدامه بسبب ضيق هامشه العلاجي، وطول عمره النصفي. (ar) Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis. Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after two to four weeks or longer. Patients who have received the medication are advised against giving blood for at least three years due to the risk of birth defects. (en) Acitretin ist ein Retinoid, das als Arzneistoff in der Behandlung gegen Schuppenflechte und andere Hauterkrankungen eingesetzt wird. (de) L'acitrétine est un antiacnéique du groupe des rétinoïdes. (fr) 아시트레틴(Acitretin, 상품명 소리아탄 또는 네오티가손)은 2세대 제제이다. 보통 건선에 처방되는 경구투여제이다. 이 제제는 아시트레틴의 전구물질인 의 대사물질이다. 에트레티네이트는 치료지수가 좁을뿐만 아니라 반감기도 120일로써 길기 때문에 투약하기가 어려워 제조가 중지되었다. 아시트레틴의 반감기는 약 2일이다. 그러나 아시트레틴도 반감기가 매우 긴 에트레티네이트로 역대사될 수 있으므로 여성은 투약 종료후 3년이내 임신을 하면 안 된다. 따라서 아시트레틴은 임신부가 될 위험이 있는 여성에게는 보통 권장되지 않는다. 아시트레틴은 악성 건선의 치료에 이용되는 레티노이드 제제이다. 부작용이 심각하기 때문에 이 제제는 다른 치료법에 반응이 없는 심각한 건선환자에 주로 이용된다. 이 제제는 유전자 전사를 막는 핵 수용기를 결합하고 케타틴 생성 세포 분화를 촉진하고 표피 과형성을 억제해 세포 재분화를 억제한다. 아시트레틴은 신속히 흡수되고 경구투여 후 광범위하게 확산된다. 효과는 2~4주 이상부터 나타난다. 이 제제를 처방받은 환자는 임신부가 피를 수혈하는 위험을 줄이기 위해 투약 종료 후 최소한 3년 이상 헌혈을 하지 않는 것이 좋다. (ko) Acytretyna – organiczny związek chemiczny, syntetyczny, aromatyczny analog kwasu retinowego, stosowany głównie w leczeniu objawowym ciężkich postaci łuszczycy oraz zaburzeń keratynizacji skóry. (pl) L'acitretina è un farmaco attivo nella psoriasi e in altri disturbi della cheratinizzazione come la malattia di Darier, la pityriasis rubra pilaris. (it) Acitretine is een synthetisch vitamine A-derivaat. Dit geneesmiddel is een tweede-generatie retinoïde, dat wordt gebruikt voor de behandeling van ernstige vormen van psoriasis en andere ernstige huidaandoeningen zoals de ziekte van Darier en harlekijnichtyose wanneer andere behandelingen niet werken. Het wordt verkocht onder de merknaam Neotigason in capsules voor oraal gebruik met 10 of 25 milligram van het middel. De chemische naam van acitretine is (all-E)-9-(4-methoxy-2,3,6-trimethylfenyl)-3,7-dimethylnona-2,4,6,8-tetraeenzuur. Het is een synthetisch analogon van all-trans-retinoïnezuur, dat ook bekend is als tretinoïne). Het werd beschreven in het Amerikaanse octrooi nr. 4105681 van 1978, als antitumormiddel en middel tegen dermatologische aandoeningen zoals acne en psoriasis. Acitretine volgde etretinaat op aan het einde van de jaren 1980, dankzij een gunstigere farmacokinetiek. De halfwaardetijd van acitretine is 50 uur, tegenover 120 dagen voor etretinaat wat een goede dosering bemoeilijkt. Acitretine is de voornaamste metaboliet van etretinaat, maar in het lichaam kan een klein deel van acitretine ook omgekeerd veresteren tot etretinaat, dat in hoge mate teratogeen is, en een groot risico vormt op ernstige aangeboren afwijkingen van het kind. Acitretine is dan ook bewezen teratogeen en het mag niet gebruikt worden tijdens zwangerschap of borstvoeding. Het middel wordt daarom ontraden aan vrouwen in de vruchtbare leeftijd. Vrouwen in de vruchtbare leeftijd dienen anticonceptieve maatregelen te nemen ten minste een maand vóór, tijdens en tot ten minste 2 jaar na staken van de therapie. Richtlijnen van de Britse Association of Dermatologists stellen dat acitretine aangeraden is in combinatie met PUVA-therapie (psoraleen plus UV-A-licht), of in combinatie met . Het wordt afgeraden in combinatie met ciclosporine of methotrexaat, bij dit laatste omwille van een verhoogde kans op ernstige hepatotoxiciteit, hoewel dit in een andere studie niet kon aangetoond worden. (nl) Acitretina é um fármaco, derivado da vitamina A que atua reduzindo a descamação da pele.É utilizado no tratamento da psoríase, ictiose congênita, pitiríase rubra pilar, doença de Darier. Antigamente era utilizado uma molécula menos especifica, chamada etretinato. Na psoríase a melhor indicação é na no tipo palmo-plantar e psoríase das unhas. No tipo, psoríase em placas a resposta terapêutica não é tão boa. Trata-se do único medicamento para psoríase que não é imuno-modulador. Há diversos efeitos colaterais como fotosensibilidade, exigindo uso de fotoprotetor; ressecamentos, exigindo hidratantes e colírio nos olhos. Contraindicando em gestantes, pois efeito de deformidade ao feto pode durar três anos depois do término do tratamento com acitretina, também contra-indicado em pessoas com dislipidemia (colesterol e triglicérides aumentados). (pt) Acitrecin är en som används för behandling av svår psoriasis. Den är besläktad med A-vitamin och tas oralt. (sv) |
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| rdfs:comment | أسيتريتين هو مركب من الجيل الثاني . يؤخذ عن طريق الفم، ويستخدم لعلاج الصدفية. وهو مستقلب من الإيتريتينيت الذي توقف استخدامه بسبب ضيق هامشه العلاجي، وطول عمره النصفي. (ar) Acitretin ist ein Retinoid, das als Arzneistoff in der Behandlung gegen Schuppenflechte und andere Hauterkrankungen eingesetzt wird. (de) L'acitrétine est un antiacnéique du groupe des rétinoïdes. (fr) 아시트레틴(Acitretin, 상품명 소리아탄 또는 네오티가손)은 2세대 제제이다. 보통 건선에 처방되는 경구투여제이다. 이 제제는 아시트레틴의 전구물질인 의 대사물질이다. 에트레티네이트는 치료지수가 좁을뿐만 아니라 반감기도 120일로써 길기 때문에 투약하기가 어려워 제조가 중지되었다. 아시트레틴의 반감기는 약 2일이다. 그러나 아시트레틴도 반감기가 매우 긴 에트레티네이트로 역대사될 수 있으므로 여성은 투약 종료후 3년이내 임신을 하면 안 된다. 따라서 아시트레틴은 임신부가 될 위험이 있는 여성에게는 보통 권장되지 않는다. 아시트레틴은 악성 건선의 치료에 이용되는 레티노이드 제제이다. 부작용이 심각하기 때문에 이 제제는 다른 치료법에 반응이 없는 심각한 건선환자에 주로 이용된다. 이 제제는 유전자 전사를 막는 핵 수용기를 결합하고 케타틴 생성 세포 분화를 촉진하고 표피 과형성을 억제해 세포 재분화를 억제한다. 아시트레틴은 신속히 흡수되고 경구투여 후 광범위하게 확산된다. 효과는 2~4주 이상부터 나타난다. 이 제제를 처방받은 환자는 임신부가 피를 수혈하는 위험을 줄이기 위해 투약 종료 후 최소한 3년 이상 헌혈을 하지 않는 것이 좋다. (ko) Acytretyna – organiczny związek chemiczny, syntetyczny, aromatyczny analog kwasu retinowego, stosowany głównie w leczeniu objawowym ciężkich postaci łuszczycy oraz zaburzeń keratynizacji skóry. (pl) L'acitretina è un farmaco attivo nella psoriasi e in altri disturbi della cheratinizzazione come la malattia di Darier, la pityriasis rubra pilaris. (it) Acitrecin är en som används för behandling av svår psoriasis. Den är besläktad med A-vitamin och tas oralt. (sv) Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis. Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after two to four weeks or longer. (en) Acitretine is een synthetisch vitamine A-derivaat. Dit geneesmiddel is een tweede-generatie retinoïde, dat wordt gebruikt voor de behandeling van ernstige vormen van psoriasis en andere ernstige huidaandoeningen zoals de ziekte van Darier en harlekijnichtyose wanneer andere behandelingen niet werken. Het wordt verkocht onder de merknaam Neotigason in capsules voor oraal gebruik met 10 of 25 milligram van het middel. (nl) Acitretina é um fármaco, derivado da vitamina A que atua reduzindo a descamação da pele.É utilizado no tratamento da psoríase, ictiose congênita, pitiríase rubra pilar, doença de Darier. Antigamente era utilizado uma molécula menos especifica, chamada etretinato. (pt) |
| rdfs:label | أسيتريتين (ar) Acitretin (de) Acitretin (en) Acitretina (it) Acitrétine (fr) 아시트레틴 (ko) Acitretine (nl) Acytretyna (pl) Acitretina (pt) Acitretin (sv) |
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