| dbo:abstract |
Technetium (99mTc) sulesomab (trade name LeukoScan) is a radio-pharmaceutical composed of anti-human mouse monoclonal antibody that targets the granulocyte associated NCA-90 cell antigen and a conjugated technetium-99m radionuclide. After intravenous administration, Leukoscan enables sensitive and specific whole body measurement of granulocyte infiltration and activation by gamma camera imaging of 99mTc-antibody bound cells. Total clearance of LeukoScan from blood samples after administration and imaging has been reported at 48 hour time points indicating limited retention of the agent in circulation It is approved in European markets for the imaging of infections and inflammations in patients with suspected osteomyelitis but has not secured FDA approval for use in American markets. In addition to approved uses, Leukoscan is currently being investigated for other diagnostic purposes like the detection of soft tissue infections, malignant external otitis and prosthetic joint infection. However, the future clinical and investigational use of this agent may be limited as sale of the agent by the parent company Immunomedics was discontinued in 2018. (en) Il 99mTc-sulesomab è un anticorpo monoclonale di topo legato chimicamente ad un radionuclide il tecnezio-99m, il cui nome commerciale è LeukoScan. Esso è approvato per la diagnostica per imaging delle infezioni e dell'infiammazione in corso di osteomielite; è anche studiato per altre indicazioni come la diagnostica dei tessuti molli. L'anticorpo agisce legandosi al recettore delle cellule granulocitiche, la glicoproteina NCA-90. (it) |
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Technetium sulesomab (en) |
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o (en) |
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mab (en) |
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| gold:hypernym |
dbr:Antibody |
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| rdfs:comment |
Il 99mTc-sulesomab è un anticorpo monoclonale di topo legato chimicamente ad un radionuclide il tecnezio-99m, il cui nome commerciale è LeukoScan. Esso è approvato per la diagnostica per imaging delle infezioni e dell'infiammazione in corso di osteomielite; è anche studiato per altre indicazioni come la diagnostica dei tessuti molli. L'anticorpo agisce legandosi al recettore delle cellule granulocitiche, la glicoproteina NCA-90. (it) Technetium (99mTc) sulesomab (trade name LeukoScan) is a radio-pharmaceutical composed of anti-human mouse monoclonal antibody that targets the granulocyte associated NCA-90 cell antigen and a conjugated technetium-99m radionuclide. After intravenous administration, Leukoscan enables sensitive and specific whole body measurement of granulocyte infiltration and activation by gamma camera imaging of 99mTc-antibody bound cells. Total clearance of LeukoScan from blood samples after administration and imaging has been reported at 48 hour time points indicating limited retention of the agent in circulation (en) |
| rdfs:label |
Sulesomab (it) Technetium (99mTc) sulesomab (en) |
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