| dbo:abstract |
T-box (en español "caja T") hace referencia a un grupo de factores de transcripción implicados en el desarrollo de las extremidades y del corazón. En humanos y en algunos otros animales, defectos en la expresión génica del gen TBX5 pueden conducir a defectos en los pulgares y el septo ventricular, lo que da lugar a que no se produzca una correcta separación entre los ventrículos izquierdo y derecho del corazón. (es) Les T-box constituent une famille de protéines avec un rôle de facteur de transcription. (fr) T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT. (en) Tボックス(T-box) は、脚および心臓の発生に関与する一群の転写因子である 。 ヒトおよびある種の動物では、TBX5の遺伝子発現は拇指三節症や心室中隔欠損、Holt-Oram 症候群の原因となる。TBX3 は尺骨乳房症候群の原因となる。 (ja) |
| dbo:symbol |
T-box |
| dbo:thumbnail |
wiki-commons:Special:FilePath/1H6F.png?width=300 |
| dbo:wikiPageExternalLink |
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/42140/335-8-11-799_8n11p799.pdf;jsessionid=6BA755F775C7632A8CF1E67036AF792F%3Fsequence=1 |
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12045475 (xsd:integer) |
| dbo:wikiPageLength |
10187 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1123105274 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Carpal_bones dbr:Mouse dbr:Bilateria dbr:Brachyury dbr:Apical_ectodermal_ridge dbr:Holt–Oram_syndrome dbr:Homeobox dbr:Dun_gene dbr:Limb_bud dbr:Limb_development dbr:TBX6 dbr:Ulnar–mammary_syndrome dbr:TBX1 dbr:Gene_expression dbr:TBX2 dbr:Cnidaria dbr:TBX3 dbr:TBX4 dbr:Zebrafish dbr:Embryo dbr:TBR1 dbr:Transcription_factor dbr:Heart dbc:Transcription_factors dbr:Fibroblast_growth_factor dbr:Hox_gene dbr:Rabbit dbr:X-ray_crystallography dbr:Xenopus_laevis dbr:Ventricle_(heart) dbr:Ventricular_septal_defect dbr:Wnt_signaling_pathway dbr:TBX21 dbr:TBX5_(gene) dbr:Zone_of_polarizing_activity dbr:TBX15 dbr:W-box dbr:TBX22 dbr:TBX19 dbr:TBX20 dbr:TBX5 dbr:TBXT dbr:I-box dbr:TBX10 dbr:TBX18 dbr:G-box dbr:Z-box |
| dbp:caption |
Crystallographic structure of the TBX3 protein dimer complexed with DNA based on the coordinates. (en) |
| dbp:interpro |
IPR001699 (en) |
| dbp:name |
T-box (en) |
| dbp:pdb |
, (en) |
| dbp:pfam |
PF00907 (en) |
| dbp:prosite |
PS50252 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
T-box (en) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_journal dbt:Div_col dbt:Div_col_end dbt:For dbt:Gene dbt:MeshName dbt:Protein-stub dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:PDB2 dbt:PDB dbt:Transcription_factors dbt:Pfam_box |
| dcterms:subject |
dbc:Transcription_factors |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatTranscriptionFactors yago:Abstraction100002137 yago:Beginning107290905 yago:Cause107326557 yago:Chemical114806838 yago:Compound114818238 yago:Event100029378 yago:Factor107327805 yago:Happening107283608 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Origin107323922 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:YagoPermanentlyLocatedEntity dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins |
| rdfs:comment |
T-box (en español "caja T") hace referencia a un grupo de factores de transcripción implicados en el desarrollo de las extremidades y del corazón. En humanos y en algunos otros animales, defectos en la expresión génica del gen TBX5 pueden conducir a defectos en los pulgares y el septo ventricular, lo que da lugar a que no se produzca una correcta separación entre los ventrículos izquierdo y derecho del corazón. (es) Les T-box constituent une famille de protéines avec un rôle de facteur de transcription. (fr) T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT. (en) Tボックス(T-box) は、脚および心臓の発生に関与する一群の転写因子である 。 ヒトおよびある種の動物では、TBX5の遺伝子発現は拇指三節症や心室中隔欠損、Holt-Oram 症候群の原因となる。TBX3 は尺骨乳房症候群の原因となる。 (ja) |
| rdfs:label |
T-box (es) T-box (fr) Tボックス (ja) T-box (en) |
| owl:sameAs |
freebase:T-box yago-res:T-box wikidata:T-box http://bs.dbpedia.org/resource/T-kutija dbpedia-es:T-box dbpedia-fr:T-box dbpedia-ja:T-box https://global.dbpedia.org/id/4vzTs |
| prov:wasDerivedFrom |
wikipedia-en:T-box?oldid=1123105274&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/1H6F.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:T-box |
| is dbo:wikiPageRedirects of |
dbr:Tbox_gene dbr:Tbx4 |
| is dbo:wikiPageWikiLink of |
dbr:Eomesodermin dbr:Dun_gene dbr:Limb_bud dbr:Limb_development dbr:TBX6 dbr:TBX1 dbr:Genetically_modified_virus dbr:TBX2 dbr:RNA_motif dbr:TBX3 dbr:TBX4 dbr:TBOX_(disambiguation) dbr:LeuA-Halobacteria_RNA_motif dbr:Zebrafish dbr:Persistent_truncus_arteriosus dbr:TBR1 dbr:TCF/LEF_family dbr:African_clawed_frog dbr:Chromosome_2 dbr:Cousin_syndrome dbr:Kevin_Lustig dbr:King_Charles_Spaniel dbr:DiGeorge_syndrome dbr:Fibroblast_growth_factor_and_mesoderm_formation dbr:TBX21 dbr:TBX5_(gene) dbr:Myogenesis dbr:T-box_transcription_factor_T dbr:TBX15 dbr:W-box dbr:TBX22 dbr:Transmembrane_protein_251 dbr:TBX19 dbr:TBX20 dbr:Tbox_gene dbr:Tbx4 |
| is foaf:primaryTopic of |
wikipedia-en:T-box |
