TetR (original) (raw)
TetR tetraziklinaren (tc) aurkako erresistentzia geneen erregulatzaile transkripzionala da. Tetraziklina ez dagoenean, TetR-rek kontrolatzen dituen geneen espresioa erreprimitzen du. Tetraziklina dagoenean, ordea, tc TetR-rekin bat egiten du, proteina itxuraldatuz, eta haren aktibitatea galarazten du. Horrela, geneen espresioa areagotzen da. Biologia sintetikoan TetR zabal erabiltzen da, erregulazio sare genetikoak eraikitzeko.
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| dbo:abstract | TetR es el regulador transcripcional de los genes de resistencia antibiótica a tetraciclina (tc) en Proteobacteria. En ausencia de tc, TetR reprime la expresión de los genes que controla, incluyendo su propia expresión. En presencia de tc, esta se une a TetR provocando un cambio conformacional en la proteína que impide su actividad represora. De esta manera la expresión de los genes se incrementa drásticamente. TetR es ampliamente usado en biología sintética para el diseño de redes de regulación genéticas, dada su capacidad reguladora y la ortogonalidad respecto a la red central de regulación del genoma hospedador. (es) TetR tetraziklinaren (tc) aurkako erresistentzia geneen erregulatzaile transkripzionala da. Tetraziklina ez dagoenean, TetR-rek kontrolatzen dituen geneen espresioa erreprimitzen du. Tetraziklina dagoenean, ordea, tc TetR-rekin bat egiten du, proteina itxuraldatuz, eta haren aktibitatea galarazten du. Horrela, geneen espresioa areagotzen da. Biologia sintetikoan TetR zabal erabiltzen da, erregulazio sare genetikoak eraikitzeko. (eu) Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein synthesis. The expression of Tc resistance genes is regulated by the repressor TetR. TetR represses the expression of TetA, a membrane protein that pumps out substances toxic to the bacteria like Tc, by binding the tetA operator. In Tc-resistant bacteria, TetA will pump out Tc before it can bind to the ribosome because the repressive action of TetR on TetA is halted by binding of Tc to TetR. Therefore, TetR may have an important role in helping scientists to better understand mechanisms of antibiotic resistance and how to treat antibiotic resistant bacteria. TetR is one of many proteins in the TetR protein family, which is so named because TetR is the most well characterized member. TetR is used in artificially engineered gene regulatory networks because of its capacity for fine regulation of promoters. In the absence of Tc or analogs like ATc, basal expression of TetR-regulated promoters is low, but expression rises sharply in the presence of even a minute quantity of Tc. The tetA gene is also present in the widely used E. coli cloning vector pBR322, where it is often referred to by the name of its tetracycline-resistance phenotype, TetR, not to be confused with TetR. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/TetR-overview_(2).png?width=300 |
| dbo:wikiPageExternalLink | https://archive.today/20121210214418/https:/www.bio.cmu.edu/courses/03441/TermPapers/2000TermPapers/group2/resi-reg.html https://pubchem.ncbi.nlm.nih.gov/compound/Anhydrotetracycline |
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| dbo:wikiPageWikiLink | dbr:Antimicrobial_resistance dbr:Gene_regulatory_network dbr:Operator_(biology) dbr:PBR322 dbr:Palindromic_sequence dbc:Tetracycline_antibiotics dbr:Alpha_helix dbr:310_helix dbr:Protein_dimer dbr:Protein_family dbr:Promoter_(genetics) dbr:Tetracycline dbr:Major_groove dbr:Ribosome dbr:Repressor dbr:Tetracycline_controlled_transcriptional_activation dbr:Antibiotic_resistant dbr:File:HTH_alignment_of_3_TetR_family_members.png dbr:File:TetR-DNAcomplex_(2).png dbr:File:TetR-overview_(2).png dbr:File:TetR_--TcMg-_complex_(2).png |
| dbp:wikiPageUsesTemplate | dbt:Reflist |
| dct:subject | dbc:Tetracycline_antibiotics |
| gold:hypernym | dbr:Family |
| rdf:type | yago:WikicatTetracyclineAntibiotics yago:Agent114778436 yago:Antibacterial102716205 yago:Antibiotic102716866 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:Substance100020090 |
| rdfs:comment | TetR tetraziklinaren (tc) aurkako erresistentzia geneen erregulatzaile transkripzionala da. Tetraziklina ez dagoenean, TetR-rek kontrolatzen dituen geneen espresioa erreprimitzen du. Tetraziklina dagoenean, ordea, tc TetR-rekin bat egiten du, proteina itxuraldatuz, eta haren aktibitatea galarazten du. Horrela, geneen espresioa areagotzen da. Biologia sintetikoan TetR zabal erabiltzen da, erregulazio sare genetikoak eraikitzeko. (eu) TetR es el regulador transcripcional de los genes de resistencia antibiótica a tetraciclina (tc) en Proteobacteria. En ausencia de tc, TetR reprime la expresión de los genes que controla, incluyendo su propia expresión. En presencia de tc, esta se une a TetR provocando un cambio conformacional en la proteína que impide su actividad represora. De esta manera la expresión de los genes se incrementa drásticamente. (es) Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein synthesis. The expression of Tc resistance genes is regulated by the repressor TetR. TetR represses the expression of TetA, a membrane protein that pumps out substances toxic to the bacteria like Tc, by binding the tetA operator. In Tc-resistant bacteria, TetA will pump out Tc before it can bind to the ribosome because the repressive action of TetR on TetA is halted by binding of Tc to TetR. Therefore, TetR may have an important role in helping scienti (en) |
| rdfs:label | TetR (eu) TetR (es) TetR (en) |
| owl:sameAs | freebase:TetR yago-res:TetR wikidata:TetR dbpedia-es:TetR dbpedia-eu:TetR https://global.dbpedia.org/id/2LGoK |
| prov:wasDerivedFrom | wikipedia-en:TetR?oldid=1098229917&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/HTH_alignment_of_3_TetR_family_members.png wiki-commons:Special:FilePath/TetR-DNAcomplex_(2).png wiki-commons:Special:FilePath/TetR-overview_(2).png wiki-commons:Special:FilePath/TetR_--TcMg-_complex_(2).png |
| foaf:isPrimaryTopicOf | wikipedia-en:TetR |
| is dbo:wikiPageRedirects of | dbr:Tet_Repressor_protein |
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| is foaf:primaryTopic of | wikipedia-en:TetR |
