Translationally controlled tumour protein (original) (raw)
The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. TCTP is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is ind
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| dbo:abstract | The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. TCTP is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TCTP production is thought to be controlled at the translational as well as the transcriptional level. (en) |
| dbo:omim | 600763 (xsd:integer) |
| dbo:symbol | FLJ27337,tpt1,HRF, p02, p23, p21 TCTP |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1h7y_EBI.jpg?width=300 |
| dbo:wikiPageID | 11488155 (xsd:integer) |
| dbo:wikiPageLength | 14557 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1075713132 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Calcium dbr:Cancer dbr:Bcl-2-associated_X_protein dbr:Bcl-xL dbr:Protein-protein_interaction dbr:Homo_sapiens dbr:Hydrophilic dbr:Cytoskeleton dbr:Uterus dbr:Vitamin dbr:Tumor_reversion dbr:Gene_expression dbr:Gene_regulation dbr:Apoptosis dbr:Alpha_helices dbr:Mammalia dbr:Actin dbr:Cell_(biology) dbr:Transcription_(genetics) dbr:Tumor dbr:Laurent_Susini dbr:Heat_shock dbr:Eukaryote dbr:Eukaryotes dbr:Cell_cycle dbr:Cell_growth dbr:Cell_proliferation dbr:Binding_(molecular) dbr:Protein dbr:Regulation_of_gene_expression dbc:Protein_domains dbr:Guanine dbr:Homology_(biology) dbr:Translation_(biology) dbr:Plants dbr:Class_(biology) dbr:Mcl-1 dbr:Chaperone_(protein) dbr:Molecular_binding dbr:Sequence_(biology) dbr:Tubulin dbr:Allergic_reaction dbr:Trypanosoma_brucei dbr:Translational dbr:Tumour dbr:Secondary_structure dbr:Embryo_development dbr:N-terminal dbr:Molecular_chaperone dbr:P53_tumour_suppressor dbr:Beta-sheets |
| dbp:caption | translationally controlled tumor-associated protein p23fyp from schizosaccharomyces pombe (en) |
| dbp:interpro | IPR018105 (en) |
| dbp:name | TCTP (en) Translationally Controlled Tumour Protein (en) |
| dbp:omim | 600763 (xsd:integer) |
| dbp:pfam | PF00838 (en) |
| dbp:pfamClan | CL0080 (en) |
| dbp:prosite | PDOC00768 (en) |
| dbp:scop | 2.209032E8 |
| dbp:symbol | TCTP (en) FLJ27337,tpt1,HRF, p02, p23, p21 (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist dbt:Infobox_protein |
| dcterms:subject | dbc:Protein_domains |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains |
| rdfs:comment | The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. TCTP is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is ind (en) |
| rdfs:label | Translationally controlled tumour protein (en) |
| owl:sameAs | freebase:Translationally controlled tumour protein yago-res:Translationally controlled tumour protein wikidata:Translationally controlled tumour protein https://global.dbpedia.org/id/2L7D8 |
| prov:wasDerivedFrom | wikipedia-en:Translationally_controlled_tumour_protein?oldid=1075713132&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1h7y_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Translationally_controlled_tumour_protein |
| foaf:name | (en) Translationally Controlled Tumour Protein (en) |
| is dbo:wikiPageWikiLink of | dbr:Laurent_Susini |
| is foaf:primaryTopic of | wikipedia-en:Translationally_controlled_tumour_protein |
