Belnacasan (original) (raw)
Belnacasan (VX-765) is a drug developed by Vertex Pharmaceuticals which acts as a potent and selective inhibitor of the enzyme caspase 1. This enzyme is involved in inflammation and cell death, and consequently blocking its action may be useful for various medical applications, including treatment of epilepsy, arthritis, aiding recovery from heart attack and slowing the progression of Alzheimer's disease. Belnacasan is an orally active prodrug, being converted in the body to the active drug VRT-043198 (O-desethyl-belnacasan). However while belnacasan has proved well tolerated in human clinical trials, it has not shown sufficient efficacy to be approved for use for any of the applications suggested to date, though research continues into possible future uses of this or similar drugs.
| Property | Value |
|---|---|
| dbo:abstract | Belnacasan (VX-765) is a drug developed by Vertex Pharmaceuticals which acts as a potent and selective inhibitor of the enzyme caspase 1. This enzyme is involved in inflammation and cell death, and consequently blocking its action may be useful for various medical applications, including treatment of epilepsy, arthritis, aiding recovery from heart attack and slowing the progression of Alzheimer's disease. Belnacasan is an orally active prodrug, being converted in the body to the active drug VRT-043198 (O-desethyl-belnacasan). However while belnacasan has proved well tolerated in human clinical trials, it has not shown sufficient efficacy to be approved for use for any of the applications suggested to date, though research continues into possible future uses of this or similar drugs. (en) |
| dbo:casNumber | 273404-37-8 |
| dbo:fdaUniiCode | 00OLE78529 |
| dbo:kegg | D10416 |
| dbo:pubchem | 11398092 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Belnacasan_structure.png?width=300 |
| dbo:wikiPageID | 58826759 (xsd:integer) |
| dbo:wikiPageLength | 4300 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1036193235 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Epilepsy dbr:Vertex_Pharmaceuticals dbr:Inflammation dbr:Clinical_trial dbr:Prodrug dbr:Alzheimer's_disease dbc:Enzyme_inhibitors dbr:Heart_attack dbr:Arthritis dbr:Caspase_1 |
| dbp:c | 24 (xsd:integer) |
| dbp:casNumber | 273404 (xsd:integer) |
| dbp:chemspiderid | 9572992 (xsd:integer) |
| dbp:cl | 1 (xsd:integer) |
| dbp:h | 33 (xsd:integer) |
| dbp:iupacName | -1 (xsd:integer) |
| dbp:kegg | D10416 (en) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 6 (xsd:integer) |
| dbp:pubchem | 11398092 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | CCO[C@@H]3OCC[C@@H]3NC[C@@H]2CCCN2C[C@@H]CC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | SJDDOCKBXFJEJB-MOKWFATOSA-N (en) |
| dbp:unii | 0 (xsd:integer) |
| dbp:width | 200 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Pharm-stub dbt:Reflist dbt:Fdacite |
| dcterms:subject | dbc:Enzyme_inhibitors |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Belnacasan (VX-765) is a drug developed by Vertex Pharmaceuticals which acts as a potent and selective inhibitor of the enzyme caspase 1. This enzyme is involved in inflammation and cell death, and consequently blocking its action may be useful for various medical applications, including treatment of epilepsy, arthritis, aiding recovery from heart attack and slowing the progression of Alzheimer's disease. Belnacasan is an orally active prodrug, being converted in the body to the active drug VRT-043198 (O-desethyl-belnacasan). However while belnacasan has proved well tolerated in human clinical trials, it has not shown sufficient efficacy to be approved for use for any of the applications suggested to date, though research continues into possible future uses of this or similar drugs. (en) |
| rdfs:label | Belnacasan (en) |
| owl:sameAs | wikidata:Belnacasan https://global.dbpedia.org/id/2Xxh8 |
| prov:wasDerivedFrom | wikipedia-en:Belnacasan?oldid=1036193235&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Belnacasan_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Belnacasan |
| is dbo:wikiPageRedirects of | dbr:C24H33ClN4O6 dbr:VX-765 |
| is dbo:wikiPageWikiLink of | dbr:C24H33ClN4O6 dbr:Caspase_1 dbr:VX-765 |
| is foaf:primaryTopic of | wikipedia-en:Belnacasan |
