Class III PI 3-kinase (original) (raw)
Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, PIK3R4(p150, Vps15).
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| dbo:abstract | Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, PIK3R4(p150, Vps15). (en) Фосфоинозитид-3-киназа классa 3 (фосфатидилинозитол-3-киназа класс 3; англ. Phosphoinositide 3-kinase, class 3, hVps34) — фермент-киназа, катализирующий реакцию фосфорилирования фосфатидилинозитола до фосфатидилинозитол-3-фосфата. Участвует в рецепторных сигнальных путях и внутриклеточном транспорте белков. Фосфоинозитид-3-киназа класса 3 в дрожжах (Vps34) участвует в сортировке секретируемых белков в вакуоли. В клетках человека hVps34 ассоциируется с регуляторной субъединицей PIK3R4 (p150, Vps15). (ru) |
| dbo:wikiPageExternalLink | http://jcs.biologists.org/cgi/content/full/116/15/3037 https://web.archive.org/web/20060102214308/http:/www.ludwig.ucl.ac.uk/cellsig_pdf/VanhaesebroeckB1999c.pdf https://web.archive.org/web/20081201145221/http:/erc.endocrinology-journals.org/cgi/content/abstract/8/3/237 |
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| dbo:wikiPageWikiLink | dbr:Calmodulin dbr:Endosome dbr:MTORC1 dbr:Saccharomyces_cerevisiae dbc:EC_2.7.1 dbr:Phosphoinositide_3-kinase dbr:Calmodulin_binding_domain dbr:PIK3C3 dbr:PIK3R4 dbr:Drosophila dbr:EGTA_(chemical) dbr:Eukaryotic dbr:Autophagy dbr:Phosphatidylinositol dbr:FYVE_domain dbr:Myristoylation dbr:RAB5A dbr:PX_domain dbr:PtdIns(3)P dbr:S6K dbr:RAB7 dbr:SiRNA dbr:Phosphoinositide_binding_domain |
| dbp:wikiPageUsesTemplate | dbt:Enzymes dbt:Kinases dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist |
| dcterms:subject | dbc:EC_2.7.1 |
| gold:hypernym | dbr:Subgroup |
| rdf:type | dbo:EthnicGroup |
| rdfs:comment | Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, PIK3R4(p150, Vps15). (en) Фосфоинозитид-3-киназа классa 3 (фосфатидилинозитол-3-киназа класс 3; англ. Phosphoinositide 3-kinase, class 3, hVps34) — фермент-киназа, катализирующий реакцию фосфорилирования фосфатидилинозитола до фосфатидилинозитол-3-фосфата. Участвует в рецепторных сигнальных путях и внутриклеточном транспорте белков. Фосфоинозитид-3-киназа класса 3 в дрожжах (Vps34) участвует в сортировке секретируемых белков в вакуоли. В клетках человека hVps34 ассоциируется с регуляторной субъединицей PIK3R4 (p150, Vps15). (ru) |
| rdfs:label | Class III PI 3-kinase (en) Фосфоинозитид-3-киназа класс 3 (ru) |
| owl:sameAs | freebase:Class III PI 3-kinase wikidata:Class III PI 3-kinase dbpedia-fa:Class III PI 3-kinase dbpedia-ru:Class III PI 3-kinase https://global.dbpedia.org/id/2bNcZ |
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