| dbo:abstract |
Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that is necessary for the body to make cholesterol. Generic versions were approved in 2017. The combination preparation is marketed by Merck & Co. under the trade names Vytorin in the US and Inegy in the European Union. In 2018, it was the 349th most commonly prescribed medication in the United States, with more than 800 thousand prescriptions. (en) |
| dbo:alternativeName |
Vytorin (US), Inegy (EU) (en) |
| dbo:casNumber |
163222-33-1 79902-63-9 |
| dbo:drugbank |
DB00641 DB00973 |
| dbo:fdaUniiCode |
AGG2FN16EV EOR26LQQ24 |
| dbo:kegg |
D10257 |
| dbo:pubchem |
9832423 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Ezetimibe_and_simvastatin.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/ezetimibe%20mixture%20with%20simvastatin |
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dbr:Pharyngitis dbr:Rhabdomyolysis dbr:Verapamil dbr:Dyslipidemia dbr:Intima-media_thickness dbr:Oral_administration dbr:Clarithromycin dbr:Enzyme dbr:Angioedema dbr:Simvastatin dbr:Statin dbr:Pie dbr:HMG-CoA_reductase dbr:Eczema dbr:Fatigue_(medical) dbr:American_College_of_Cardiology dbr:Amiodarone dbr:Danazol dbr:Erythromycin dbr:Ezetimibe dbr:Familial_hypercholesterolemia dbr:Grapefruit dbc:Hypolipidemic_agents dbr:Telithromycin dbr:Atorvastatin dbc:Combination_drugs dbc:Merck_&_Co._brands dbr:LDL dbr:Hepatitis dbc:Schering-Plough_brands dbr:Merck_&_Co. dbr:Brush_border dbr:Nefazodone dbr:Niacin_(substance) dbr:Sinusitis dbr:Myalgia dbr:Myopathy dbr:United_States_House_Committee_on_Energy_and_Commerce dbr:Protease_inhibitors dbr:Niemann-Pick_C1-Like_1 dbr:Cyclosporine |
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10.0 |
| dbp:atcSuffix |
BA02 (en) |
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49 (xsd:integer) |
| dbp:casNumber |
79902 (xsd:integer) 163222 (xsd:integer) |
| dbp:chemspiderid |
21106308 (xsd:integer) |
| dbp:class |
Statin HMG-CoA reductase inhibitor (en) via Niemann-Pick C1-Like 1 protein (en) |
| dbp:component |
Ezetimibe (en) Simvastatin (en) |
| dbp:dailymedid |
Vytorin (en) |
| dbp:drugbank |
DB00641 (en) DB00973 (en) |
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2 (xsd:integer) |
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59 (xsd:integer) |
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D10257 (en) |
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S4 (en) |
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Rx-only (en) |
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Rx-only (en) |
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1 (xsd:integer) |
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dbr:Oral_administration |
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CCCCOC1CCC.C1=CCO (en) |
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1 (xsd:integer) |
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PNAMDJVUJCJOIX-IUNFJCKHSA-N (en) |
| dbp:tradename |
Vytorin , Inegy (en) |
| dbp:type |
combo (en) |
| dbp:unii |
AGG2FN16EV (en) EOR26LQQ24 (en) |
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changed (en) |
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448787104 (xsd:integer) |
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changed (en) |
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| dcterms:subject |
dbc:Hypolipidemic_agents dbc:Combination_drugs dbc:Merck_&_Co._brands dbc:Schering-Plough_brands |
| gold:hypernym |
dbr:Combination |
| rdf:type |
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| rdfs:comment |
Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. (en) |
| rdfs:label |
Ezetimibe/simvastatin (en) |
| owl:sameAs |
freebase:Ezetimibe/simvastatin yago-res:Ezetimibe/simvastatin http://api.nytimes.com/svc/semantic/v2/concept/name/nytd_des/Vytorin%20(Drug) http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00973 wikidata:Ezetimibe/simvastatin http://azb.dbpedia.org/resource/ایزتیب_/_سیمواستاتین dbpedia-sh:Ezetimibe/simvastatin dbpedia-simple:Ezetimibe/simvastatin dbpedia-sr:Ezetimibe/simvastatin dbpedia-vi:Ezetimibe/simvastatin https://global.dbpedia.org/id/4jGnt |
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wikipedia-en:Ezetimibe/simvastatin?oldid=1120448940&ns=0 |
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wiki-commons:Special:FilePath/Ezetimibe_and_simvastatin.svg |
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wikipedia-en:Ezetimibe/simvastatin |
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dbr:Ezetimibe;_simvastatin dbr:ATC_code_C10BA02 dbr:ATCvet_code_QC10BA02 dbr:Inegy dbr:Vytorin dbr:Simvastatin/ezetimibe |
| is dbo:wikiPageWikiLink of |
dbr:Schering-Plough dbr:Ezetimibe;_simvastatin dbr:Robert_Califf dbr:List_of_largest_selling_pharmaceutical_products dbr:Statin dbr:ATC_code_C10BA02 dbr:Ezetimibe dbr:ATCvet_code_QC10BA02 dbr:ATC_code_C10 dbr:Inegy dbr:Ezetimibe/atorvastatin dbr:Vytorin dbr:Simvastatin/ezetimibe |
| is foaf:primaryTopic of |
wikipedia-en:Ezetimibe/simvastatin |
