ASB6 (original) (raw)

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Protein-coding gene in the species Homo sapiens

ASB6
Identifiers
Aliases ASB6, ankyrin repeat and SOCS box containing 6
External IDs OMIM: 615051; MGI: 1919573; HomoloGene: 9895; GeneCards: ASB6; OMA:ASB6 - orthologs
Gene location (Human)Chromosome 9 (human)Chr.Chromosome 9 (human)[1]Chromosome 9 (human)Genomic location for ASB6Genomic location for ASB6Band9q34.11Start129,634,604 bp[1]End129,642,169 bp[1]
Gene location (Mouse)Chromosome 2 (mouse)Chr.Chromosome 2 (mouse)[2]Chromosome 2 (mouse)Genomic location for ASB6Genomic location for ASB6Band2|2 BStart30,713,109 bp[2]End30,720,345 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingranulocyteright frontal lobegastric mucosaright hemisphere of cerebellumprefrontal cortexleft adrenal cortexmiddle temporal gyrusright adrenal cortexanterior cingulate cortexskin of legTop expressed infetal liver hematopoietic progenitor cellgranulocyteyolk saclipepiblastright kidneysubmandibular glandneural layer of retinaembryoventricular zoneMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding Cellular component cytoplasm cytosol Biological process intracellular signal transduction protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez14045972323EnsemblENSG00000148331ENSMUSG00000039483UniProtQ9NWX5Q91ZU1RefSeq (mRNA)NM_177999NM_001202403NM_017873NM_133346RefSeq (protein)NP_001189332NP_060343NP_821066NP_579924Location (UCSC)Chr 9: 129.63 – 129.64 MbChr 2: 30.71 – 30.72 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.[5]

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148331 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039483 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ASB6 ankyrin repeat and SOCS box-containing 6".