BCAS3 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

BCAS3
Identifiers
Aliases	BCAS3, GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor, BCAS3 microtubule associated cell migration factor, PHAF2, HEMARS
External IDs	OMIM: 607470; MGI: 2385848; HomoloGene: 9778; GeneCards: BCAS3; OMA:BCAS3 - orthologs
Gene location (Human)Chr.Chromosome 17 (human)[1]Band17q23.2Start60,677,453 bp[1]End61,392,838 bp[1]
Gene location (Mouse)Chr.Chromosome 11 (mouse)[2]Band11|11 CStart85,353,167 bp[2]End85,826,058 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inepithelium of colonsural nerveright uterine tubebone marrow cellAchilles tendonprefrontal cortextesticleolfactory zone of nasal mucosaright coronary arterypopliteal arteryTop expressed inseminal vesiculamorulamuscle of thighneural layer of retinasuperior frontal gyrusdentate gyrus of hippocampal formation granule cellgenital tubercleblastocystlipyolk sacMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function histone binding chromatin binding acetyltransferase activator activity beta-tubulin binding histone acetyltransferase binding transcription factor binding protein binding Cellular component intermediate filament cytoskeleton nucleolus cell periphery cell leading edge cytoplasmic microtubule cytoskeleton nucleus cytoplasm Biological process angiogenesis cellular response to estrogen stimulus positive regulation of endothelial cell migration positive regulation of GTPase activity positive regulation of intracellular protein transport transcription, DNA-templated positive regulation of actin cytoskeleton reorganization microtubule organizing center organization negative regulation of focal adhesion assembly response to starvation activation of GTPase activity Golgi organization regulation of establishment of cell polarity tube formation regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of GTPase activity positive regulation of catalytic activity positive regulation of filopodium assembly vesicle-mediated transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez54828192197EnsemblENSG00000141376ENSMUSG00000059439UniProtQ9H6U6Q8CCN5RefSeq (mRNA)NM_001099432NM_017679NM_001320470NM_001330413NM_001330414NM_001353144NM_001353145NM_001353146NM_001166642NM_001166643NM_138681RefSeq (protein)NP_001092902NP_001307399NP_001317342NP_001317343NP_060149NP_001340073NP_001340074NP_001340075NP_001160114NP_001160115NP_619622Location (UCSC)Chr 17: 60.68 – 61.39 MbChr 11: 85.35 – 85.83 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[5][6] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[6]

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[8][_better source needed_] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[8][_better source needed_]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141376 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059439 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
6. ^ a b Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
7. ^ Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
8. ^ a b Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058. (Retracted, see doi:10.1210/me.2014-1149, Retraction Watch)

• Human BCAS3 genome location and BCAS3 gene details page in the UCSC Genome Browser.

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

• Bärlund M, Monni O, Weaver JD, et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

• Gururaj AE, Singh RR, Rayala SK, et al. (2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.

• Gururaj AE, Holm C, Landberg G, Kumar R (2006). "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle. 5 (13): 1407–10. doi:10.4161/cc.5.13.2924. PMID 16855396.

• Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058. (Retracted, see doi:10.1210/me.2014-1149, Retraction Watch)