DDX31 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

DDX31
Identifiers
Aliases	DDX31, PPP1R25, DEAD-box helicase 31
External IDs	OMIM: 616533; MGI: 2682639; HomoloGene: 6389; GeneCards: DDX31; OMA:DDX31 - orthologs
Gene location (Human)Chr.Chromosome 9 (human)[1]Band9q34.13Start132,592,997 bp[1]End132,670,401 bp[1]
Gene location (Mouse)Chr.Chromosome 2 (mouse)[2]Band2|2 A3Start28,730,418 bp[2]End28,795,583 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingonadright lobe of thyroid glandleft lobe of thyroid glandcerebellar hemisphereright hemisphere of cerebellumskin of legislet of Langerhansskin of abdomentibial nervetesticleTop expressed inlumbar spinal ganglionPaneth cellcondyleotic vesicleprimitive streakfossamedullary collecting ductaortic valvetail of embryoepiblastMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component Golgi apparatus intracellular membrane-bounded organelle nucleus nucleolus cytoplasm Biological process ribosome biogenesis RNA secondary structure unwinding Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez64794227674EnsemblENSG00000125485ENSMUSG00000026806UniProtQ9H8H2Q6NZQ2RefSeq (mRNA)NM_022779NM_138620NM_001322340NM_001322341NM_001322342NM_001322343NM_001322344NM_001033294RefSeq (protein)NP_001309269NP_001309270NP_001309271NP_001309272NP_001309273NP_073616NP_619526NP_001028466Location (UCSC)Chr 9: 132.59 – 132.67 MbChr 2: 28.73 – 28.8 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31, also known as DDX31, is a human gene.[5]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants.[5]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125485 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026806 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31".

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abdelhaleem M, Maltais L, Wain H (2004). "The human DDX and DHX gene families of putative RNA helicases". Genomics. 81 (6): 618–22. doi:10.1016/S0888-7543(03)00049-1. PMID 12782131.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.