FBXO9 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FBXO9
Identifiers
Aliases FBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box protein 9
External IDs OMIM: 609091; MGI: 1918788; HomoloGene: 8217; GeneCards: FBXO9; OMA:FBXO9 - orthologs
Gene location (Human)Chromosome 6 (human)Chr.Chromosome 6 (human)[1]Chromosome 6 (human)Genomic location for FBXO9Genomic location for FBXO9Band6p12.1Start53,051,991 bp[1]End53,100,873 bp[1]
Gene location (Mouse)Chromosome 9 (mouse)Chr.Chromosome 9 (mouse)[2]Chromosome 9 (mouse)Genomic location for FBXO9Genomic location for FBXO9Band9|9 E1Start77,988,781 bp[2]End78,016,347 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inendothelial cellBrodmann area 23middle temporal gyrusright adrenal glandright adrenal cortexsecondary oocyteleft adrenal glandtrabecular boneleft adrenal cortextibiaTop expressed inmedial vestibular nucleusbloodciliary bodyretinal pigment epitheliumdorsal tegmental nucleuspontine nucleideep cerebellar nucleimotor neuronmedial geniculate nucleusventral tegmental areaMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding ubiquitin-protein transferase activity Cellular component cytoplasm ubiquitin ligase complex SCF ubiquitin ligase complex cytosol Biological process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process innate immune response regulation of TOR signaling fat cell differentiation protein ubiquitination protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez2626871538EnsemblENSG00000112146ENSMUSG00000001366UniProtQ9UK97Q8BK06RefSeq (mRNA)NM_012347NM_033480NM_033481NM_001081490NM_023605RefSeq (protein)NP_036479NP_258441NP_258442NP_001074959NP_076094Location (UCSC)Chr 6: 53.05 – 53.1 MbChr 9: 77.99 – 78.02 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112146 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. ^ a b "Entrez Gene: FBXO9 F-box protein 9".