FBXW5 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FBXW5
Identifiers
Aliases FBXW5, Fbw5, F-box and WD repeat domain containing 5
External IDs OMIM: 609072; MGI: 1354731; HomoloGene: 8496; GeneCards: FBXW5; OMA:FBXW5 - orthologs
Gene location (Human)Chromosome 9 (human)Chr.Chromosome 9 (human)[1]Chromosome 9 (human)Genomic location for FBXW5Genomic location for FBXW5Band9q34.3Start136,940,435 bp[1]End136,944,738 bp[1]
Gene location (Mouse)Chromosome 2 (mouse)Chr.Chromosome 2 (mouse)[2]Chromosome 2 (mouse)Genomic location for FBXW5Genomic location for FBXW5Band2|2 A3Start25,390,762 bp[2]End25,395,483 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inright testisleft testisapex of heartpopliteal arterytibial arteriesmuscle of thighgastrocnemius musclegranulocyteright lobe of liverright coronary arteryTop expressed inspermatocytespermatidseminiferous tubulemuscle of thighentorhinal cortexsuperior frontal gyrusprimary visual cortexsacculeperirhinal cortexright kidneyMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding protein kinase binding ubiquitin-protein transferase activity Cellular component Cul4-RING E3 ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex cytosol Biological process proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination regulation of centrosome duplication SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein polyubiquitination regulation of mitotic nuclear division post-translational protein modification Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez5446130839EnsemblENSG00000159069ENSMUSG00000015095UniProtQ969U6Q9QXW2RefSeq (mRNA)NM_018998NM_178225NM_178226NM_013908NM_001356407NM_001356408RefSeq (protein)NP_061871NP_038936NP_001343336NP_001343337Location (UCSC)Chr 9: 136.94 – 136.94 MbChr 2: 25.39 – 25.4 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
  6. ^ Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, et al. (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.
  7. ^ Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.