HINT1 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

HINT1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F
Identifiers
Aliases HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1
External IDs OMIM: 601314; MGI: 1321133; HomoloGene: 3904; GeneCards: HINT1; OMA:HINT1 - orthologs
Gene location (Human)Chromosome 5 (human)Chr.Chromosome 5 (human)[1]Chromosome 5 (human)Genomic location for HINT1Genomic location for HINT1Band5q23.3Start131,155,383 bp[1]End131,224,468 bp[1]
Gene location (Mouse)Chromosome 11 (mouse)Chr.Chromosome 11 (mouse)[2]Chromosome 11 (mouse)Genomic location for HINT1Genomic location for HINT1Band11|11 B1.3Start54,757,209 bp[2]End54,761,327 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inendothelial celloocytemiddle temporal gyrusBrodmann area 23ponsepithelium of nasopharynxgingival epitheliumrenal medullaseminal vesiculaspinal gangliaTop expressed infossarenal corpusclePaneth cellcondyleendothelial cell of lymphatic vesselmedullary collecting ductfacial motor nucleusbarrel cortexEpithelium of choroid plexusvas deferensMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function nucleotide binding catalytic activity hydrolase activity protein kinase C binding Cellular component histone deacetylase complex plasma membrane extracellular exosome cytoskeleton nucleus cytoplasm cytosol Biological process purine ribonucleotide catabolic process positive regulation of calcium-mediated signaling regulation of transcription, DNA-templated transcription, DNA-templated intrinsic apoptotic signaling pathway by p53 class mediator signal transduction apoptotic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez309415254EnsemblENSG00000169567ENSMUSG00000020267UniProtP49773P70349RefSeq (mRNA)NM_005340NM_008248RefSeq (protein)NP_005331NP_032274Location (UCSC)Chr 5: 131.16 – 131.22 MbChr 11: 54.76 – 54.76 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.[5][6]

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group.[7] In addition, functions as scaffolding protein that modulates transcriptional activation.[8]

It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.[9][10] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.[10][11]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169567 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020267 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF (Feb 1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)". Genomics. 36 (1): 151–6. doi:10.1006/geno.1996.0435. PMID 8812426.
  6. ^ "Entrez Gene: HINT1 histidine triad nucleotide binding protein 1".
  7. ^ Strom A, Tong CL, Wagner CR (May 2020). "Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A". FEBS Letters. 594 (10): 1497–1505. doi:10.1002/1873-3468.13745. PMID 31990367. S2CID 210933742.
  8. ^ "P49773: HINT1 (human)". UniProt.
  9. ^ Wang L, Li H, Zhang Y, Santella RM, Weinstein IB (Apr 2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int J Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.
  10. ^ a b Lee YN, Nechushtan H, Figov N, Razin E (Feb 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.
  11. ^ Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (June 2009). "LysRS serves as a key signaling molecule in the immune response by regulating gene expression". Mol Cell. 34 (5): 603–11. doi:10.1016/j.molcel.2009.05.019. PMID 19524539.