PIK3R2 (original) (raw)

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Protein-coding gene in the species Homo sapiens

PIK3R2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs OMIM: 603157; MGI: 1098772; HomoloGene: 3687; GeneCards: PIK3R2; OMA:PIK3R2 - orthologs
Gene location (Mouse)Chromosome 8 (mouse)Chr.Chromosome 8 (mouse)[1]Chromosome 8 (mouse)Genomic location for PIK3R2Genomic location for PIK3R2Band8 B3.3|8 34.15 cMStart71,220,820 bp[1]End71,229,357 bp[1]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inganglionic eminencestromal cell of endometriumprefrontal cortexhippocampus propersuperior frontal gyrusleft adrenal glandnucleus accumbenstemporal lobeamygdalacaudate nucleusTop expressed inprimary visual cortexstriatum of neuraxissuperior frontal gyrushippocampus properolfactory bulbcerebellumganglionic eminencelipdentate gyrus of hippocampal formation granule cellcerebellar cortexMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function phosphatidylinositol 3-kinase regulator activity receptor tyrosine kinase binding 1-phosphatidylinositol-3-kinase regulator activity protein binding protein heterodimerization activity protein phosphatase binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase activity Cellular component cytosol phosphatidylinositol 3-kinase complex nucleus Biological process Fc-gamma receptor signaling pathway involved in phagocytosis cellular glucose homeostasis response to endoplasmic reticulum stress Fc-epsilon receptor signaling pathway phosphatidylinositol phosphate biosynthetic process vascular endothelial growth factor receptor signaling pathway regulation of autophagy regulation of phosphatidylinositol 3-kinase activity cellular response to insulin stimulus protein transport phosphatidylinositol 3-kinase signaling T cell receptor signaling pathway regulation of small GTPase mediated signal transduction phosphatidylinositol-mediated signaling leukocyte migration positive regulation of transcription by RNA polymerase II signal transduction insulin receptor signaling pathway positive regulation of GTPase activity phosphatidylinositol-3-phosphate biosynthetic process negative regulation of MAPK cascade positive regulation of protein kinase B signaling positive regulation of protein import into nucleus phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez529618709Ensembln/aENSMUSG00000031834UniProtO00459O08908RefSeq (mRNA)NM_005027NM_008841RefSeq (protein)NP_005018NP_032867Location (UCSC)n/aChr 8: 71.22 – 71.23 MbPubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[4][5]

A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.[6]

PIK3R2 has been shown to interact with:

PIK3R2 mutations were recently shown to be associated with polymicrogyria.[12]

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031834 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–793. PMID 1314371.
  5. ^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
  6. ^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.
  7. ^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
  8. ^ Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
  9. ^ Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
  10. ^ a b c d Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
  11. ^ Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
  12. ^ Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet. Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.