PLCD3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

PLCD3
Identifiers
Aliases PLCD3, PLC-delta-3, phospholipase C delta 3
External IDs OMIM: 608795; MGI: 107451; HomoloGene: 14858; GeneCards: PLCD3; OMA:PLCD3 - orthologs
Gene location (Human)Chromosome 17 (human)Chr.Chromosome 17 (human)[1]Chromosome 17 (human)Genomic location for PLCD3Genomic location for PLCD3Band17q21.31Start45,108,959 bp[1]End45,133,354 bp[1]
Gene location (Mouse)Chromosome 11 (mouse)Chr.Chromosome 11 (mouse)[2]Chromosome 11 (mouse)Genomic location for PLCD3Genomic location for PLCD3Band11 E1|11 66.71 cMStart102,961,130 bp[2]End102,992,484 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmucosa of transverse colonmuscle of thighapex of heartgastric mucosaDescending thoracic aortaright coronary arterybuccal mucosa cellleft adrenal cortexascending aortagastrocnemius muscleTop expressed inneural layer of retinagastruladeciduavestibular membrane of cochlear ductotolith organutriclemorulalipepithelium of lenssciatic nerveMore reference expression dataBioGPSn/a
Gene ontologyMolecular function hydrolase activity signal transducer activity metal ion binding phosphoric diester hydrolase activity phosphatidylinositol phospholipase C activity protein binding Cellular component cytosol plasma membrane cleavage furrow membrane cytoplasm intracellular anatomical structure Biological process angiogenesis lipid catabolic process intracellular signal transduction labyrinthine layer blood vessel development inositol phosphate metabolic process regulation of cell population proliferation lipid metabolism signal transduction inositol trisphosphate biosynthetic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez11302672469EnsemblENSG00000161714ENSMUSG00000020937UniProtQ8N3E9Q8K2J0RefSeq (mRNA)NM_133373NM_152813NM_001361706RefSeq (protein)NP_588614NP_690026NP_001348635Location (UCSC)Chr 17: 45.11 – 45.13 MbChr 11: 102.96 – 102.99 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.[5][6][7]

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161714 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020937 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 209–10. doi:10.1159/000015469. PMID 10702670. S2CID 87171791.
  6. ^ Ghosh S, Pawelczyk T, Lowenstein JM (Mar 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expression and Purification. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
  7. ^ a b "Entrez Gene: PLCD3 phospholipase C, delta 3".