PLK3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

PLK3
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4B6L
Identifiers
Aliases PLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDs OMIM: 602913; MGI: 109604; HomoloGene: 20865; GeneCards: PLK3; OMA:PLK3 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for PLK3Genomic location for PLK3Band1p34.1Start44,800,377 bp[1]End44,805,990 bp[1]
Gene location (Mouse)Chromosome 4 (mouse)Chr.Chromosome 4 (mouse)[2]Chromosome 4 (mouse)Genomic location for PLK3Genomic location for PLK3Band4|4 D1Start116,985,852 bp[2]End116,991,160 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inoocytegastric mucosaascending aortaleft uterine tubegallbladderupper lobe of left lungskin of abdomenDescending thoracic aortamonocytesecondary oocyteTop expressed inperirhinal cortexentorhinal cortexCA3 fieldgranulocytelactiferous glandchoroid plexus of fourth ventriclelipleft lobe of liverdeciduaesophagusMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transferase activity nucleotide binding protein kinase activity p53 binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm centrosome Golgi apparatus microtubule organizing center soma dendrite nucleolus Golgi stack cytoskeleton nucleus nucleoplasm spindle pole Biological process positive regulation of intracellular protein transport regulation of cytokinesis regulation of cell division protein kinase B signaling phosphorylation response to reactive oxygen species mitotic cell cycle checkpoint signaling mitotic G1/S transition checkpoint signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus response to osmotic stress protein phosphorylation G2/M transition of mitotic cell cycle cytoplasmic microtubule organization endomitotic cell cycle cell cycle response to radiation Golgi disassembly apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of signal transduction by p53 class mediator positive regulation of chaperone-mediated autophagy G1/S transition of mitotic cell cycle mitotic cell cycle Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez126312795EnsemblENSG00000173846ENSMUSG00000028680UniProtQ9H4B4Q60806RefSeq (mRNA)NM_004073NM_013807NM_001313916RefSeq (protein)NP_004064n/aLocation (UCSC)Chr 1: 44.8 – 44.81 MbChr 4: 116.99 – 116.99 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[5][6]

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[5]

PLK3 has been shown to interact with:

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173846 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028680 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".
  6. ^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
  7. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
  8. ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661. S2CID 24106070.
  9. ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.