ROR1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

ROR1
Identifiers
Aliases ROR1, NTRKR1, dJ537F10.1, receptor tyrosine kinase-like orphan receptor 1, receptor tyrosine kinase like orphan receptor 1
External IDs OMIM: 602336; MGI: 1347520; HomoloGene: 3675; GeneCards: ROR1; OMA:ROR1 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for ROR1Genomic location for ROR1Band1p31.3Start63,774,017 bp[1]End64,181,498 bp[1]
Gene location (Mouse)Chromosome 4 (mouse)Chr.Chromosome 4 (mouse)[2]Chromosome 4 (mouse)Genomic location for ROR1Genomic location for ROR1Band4 C6|4 45.71 cMStart99,952,988 bp[2]End100,301,962 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingerminal epitheliumpopliteal arterytibial arteriesislet of Langerhansright coronary arterylower lobe of lungsaphenous veinDescending thoracic aortasural nervebuccal mucosa cellTop expressed inepithelium of lensgastrulaumbilical cordabdominal walldeciduamedullary collecting ductatrioventricular valveefferent ductulevestibular sensory epitheliummaxillary prominenceMore reference expression dataBioGPSn/a
Gene ontologyMolecular function transmembrane receptor protein tyrosine kinase activity nucleotide binding protein binding protein kinase activity Wnt-protein binding kinase activity ATP binding transferase activity coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Wnt-activated receptor activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component receptor complex integral component of plasma membrane integral component of membrane membrane stress fiber cytoplasm cell surface plasma membrane axon terminus axon cell projection Biological process phosphorylation protein phosphorylation Wnt signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway Wnt signaling pathway, planar cell polarity pathway peptidyl-tyrosine phosphorylation astrocyte development hearing positive regulation of I-kappaB kinase/NF-kappaB signaling inner ear development positive regulation of NF-kappaB transcription factor activity negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade anatomical structure development Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez491926563EnsemblENSG00000185483ENSMUSG00000035305UniProtQ01973Q9Z139RefSeq (mRNA)NM_001083592NM_005012NM_013845NM_001312690RefSeq (protein)NP_001077061NP_005003NP_001299619NP_038873Location (UCSC)Chr 1: 63.77 – 64.18 MbChr 4: 99.95 – 100.3 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene.[5][6][7] ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.[5] ROR1 is currently under investigation for its role in the metastasis of cancer cells.[8]

ROR1 has recently been shown to be expressed on ovarian cancer stem cell, on which it seems to play a functional role in promoting migration/invasion or spheroid formation in vitro and tumor engraftment in immune-deficient mice. Treatment with a humanized mAb specific for ROR1 (UC-961) could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice. Moreover, such treatment inhibited the growth of tumor xenografts, which in turn had a reduced capacity to engraft immune-deficient mice and were relatively depleted of cells with features of CSC, suggesting that treatment with UC-961 could impair CSC renewal. Collectively, these studies indicate that ovarian CSCs express ROR1, which may be targeted for anti-CSC therapy.[9]

Zilovertamab vedotin (ZV), an antibody–drug conjugate comprising a monoclonal antibody recognizing extracellular ROR1, a cleavable linker and monomethyl auristatin E has entered clinical trials for the treatment of lymphoid malignancies.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035305 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: receptor tyrosine kinase-like orphan receptor 1".
  6. ^ Masiakowski P, Carroll RD (Dec 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". The Journal of Biological Chemistry. 267 (36): 26181–90. doi:10.1016/S0021-9258(18)35733-8. PMID 1334494.
  7. ^ Reddy UR, Phatak S, Pleasure D (Oct 1996). "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains". Oncogene. 13 (7): 1555–9. PMID 8875995.
  8. ^ Cui B, Zhang S, Chen L, Yu J, Widhopf GF, Fecteau JF, Rassenti LZ, Kipps TJ (June 2013). "Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis". Cancer Research. 73 (12): 3649–60. doi:10.1158/0008-5472.CAN-12-3832. PMC 3832210. PMID 23771907.
  9. ^ Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ (Dec 2014). "Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy". Proceedings of the National Academy of Sciences of the United States of America. 111 (48): 17266–71. Bibcode:2014PNAS..11117266Z. doi:10.1073/pnas.1419599111. PMC 4260559. PMID 25411317.
  10. ^ Wang M, et al. (2022). "Zilovertamab vedotin targeting of ROR1 as therapy for lymphoid cancers" (PDF). NEJM Evidence. 1 (1) EVIDoa2100001. doi:10.1056/EVIDoa2100001. PMID 38319241. S2CID 245430438.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.