SSX2 (original) (raw)

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Mammalian protein found in Homo sapiens

SSX2B
Identifiers
Aliases	SSX2B, CT5.2, CT5.2b, HOM-MEL-40, SSX, synovial sarcoma, X breakpoint 2B, SSX family member 2B
External IDs	HomoloGene: 133226; GeneCards: SSX2B; OMA:SSX2B - orthologs
Gene location (Human)Chr.X chromosome (human)[1]BandXp11.22Start52,751,132 bp[1]End52,790,305 bp[1]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingonadtesticleright testisleft testissural nerveright lobe of thyroid glandleft lobe of thyroid glandbloodrenal cortexhuman musculoskeletal systemn/aMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding transcription corepressor activity nucleic acid binding Cellular component intracellular anatomical structure nucleus Biological process negative regulation of nucleic acid-templated transcription regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez727837n/aEnsemblENSG00000268447n/aUniProtQ16385n/aRefSeq (mRNA)NM_001278702NM_001164417NM_001278701n/aRefSeq (protein)NP_001157889NP_001265630NP_001265631n/aLocation (UCSC)Chr X: 52.75 – 52.79 Mbn/aPubMed search[2]n/a
Wikidata
View/Edit Human

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.[3][4]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[4]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268447 – Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Tureci O, Sahin U, Schobert I, Koslowski M, Scmitt H, Schild HJ, Stenner F, Seitz G, Rammensee HG, Pfreundschuh M (Nov 1996). "The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40". Cancer Res. 56 (20): 4766–72. PMID 8840996.
4. ^ a b "Entrez Gene: SSX2 synovial sarcoma, X breakpoint 2".

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