VAV1 (original) (raw)

From Wikipedia, the free encyclopedia

Human protein and coding gene

VAV1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Identifiers
Aliases VAV1, VAV, vav guanine nucleotide exchange factor 1
External IDs OMIM: 164875; MGI: 98923; HomoloGene: 3961; GeneCards: VAV1; OMA:VAV1 - orthologs
Gene location (Human)Chromosome 19 (human)Chr.Chromosome 19 (human)[1]Chromosome 19 (human)Genomic location for VAV1Genomic location for VAV1Band19p13.3Start6,772,708 bp[1]End6,857,366 bp[1]
Gene location (Mouse)Chromosome 17 (mouse)Chr.Chromosome 17 (mouse)[2]Chromosome 17 (mouse)Genomic location for VAV1Genomic location for VAV1Band17 D|17 29.76 cMStart57,586,100 bp[2]End57,635,031 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingranulocytemonocytebloodspleenbone marrow celllymph nodeappendixpalpebral conjunctivaepithelium of nasopharynxtrabecular boneTop expressed insuperior surface of tonguegallbladdergranulocytethymusmesenteric lymph nodesinterventricular septumspleenbloodgastrulalumbar subsegment of spinal cordMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function guanyl-nucleotide exchange factor activity DNA-binding transcription factor activity metal ion binding protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotyrosine residue binding Cellular component cytosol cell-cell junction plasma membrane Biological process regulation of cell size intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity T cell costimulation neutrophil chemotaxis reactive oxygen species metabolic process platelet activation Fc-epsilon receptor signaling pathway positive regulation of GTPase activity T cell differentiation vascular endothelial growth factor receptor signaling pathway immune response phagocytosis positive regulation of apoptotic process integrin-mediated signaling pathway regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction positive regulation of natural killer cell mediated cytotoxicity T cell activation positive regulation of cell adhesion regulation of transcription, DNA-templated phosphatidylinositol phosphate biosynthetic process small GTPase mediated signal transduction G protein-coupled receptor signaling pathway positive regulation of protein kinase B signaling cytokine-mediated signaling pathway positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez740922324EnsemblENSG00000141968ENSMUSG00000034116UniProtP15498P27870RefSeq (mRNA)NM_001258206NM_001258207NM_005428NM_001163815NM_001163816NM_011691RefSeq (protein)NP_001245135NP_001245136NP_005419NP_001157287NP_001157288NP_035821Location (UCSC)Chr 19: 6.77 – 6.86 MbChr 17: 57.59 – 57.64 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.[5]

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.[6]

VAV1 has been shown to interact with:

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141968 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034116 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D (February 1998). "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav". Science. 279 (5350): 558–60. Bibcode:1998Sci...279..558H. doi:10.1126/science.279.5350.558. PMID 9438848.
  6. ^ "Entrez Gene: VAV1 vav 1 oncogene".
  7. ^ Groysman M, Russek CS, Katzav S (February 2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation". FEBS Lett. 467 (1): 75–80. doi:10.1016/S0014-5793(00)01121-2. PMID 10664460. S2CID 40103095.
  8. ^ Bassermann F, Jahn T, Miething C, Seipel P, Bai RY, Coutinho S, Tybulewicz VL, Peschel C, Duyster J (April 2002). "Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway". J. Biol. Chem. 277 (14): 12437–45. doi:10.1074/jbc.M112397200. PMID 11790798.
  9. ^ a b Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi ML, Capitani S (April 2001). "Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells". Cell Growth Differ. 12 (4): 193–200. PMID 11331248.
  10. ^ Marengère LE, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM (July 1997). "Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells". J. Immunol. 159 (1): 70–6. doi:10.4049/jimmunol.159.1.70. PMID 9200440.
  11. ^ Hobert O, Jallal B, Ullrich A (June 1996). "Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression". Mol. Cell. Biol. 16 (6): 3066–73. doi:10.1128/MCB.16.6.3066. PMC 231301. PMID 8649418.
  12. ^ a b Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Mol. Cell. Biol. 19 (5): 3798–807. doi:10.1128/MCB.19.5.3798. PMC 84217. PMID 10207103.
  13. ^ a b c Song JS, Gomez J, Stancato LF, Rivera J (October 1996). "Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". J. Biol. Chem. 271 (43): 26962–70. doi:10.1074/jbc.271.43.26962. PMID 8900182.
  14. ^ Ye ZS, Baltimore D (Dec 1994). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12629–33. Bibcode:1994PNAS...9112629Y. doi:10.1073/pnas.91.26.12629. PMC 45492. PMID 7809090.
  15. ^ a b Lee IS, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T (January 1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Lett. 401 (2–3): 133–7. doi:10.1016/s0014-5793(96)01456-1. PMID 9013873. S2CID 32632406.
  16. ^ a b Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity". J. Biol. Chem. 272 (22): 14334–40. doi:10.1074/jbc.272.22.14334. PMID 9162069.
  17. ^ Matsuguchi T, Inhorn RC, Carlesso N, Xu G, Druker B, Griffin JD (January 1995). "Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL". EMBO J. 14 (2): 257–65. doi:10.1002/j.1460-2075.1995.tb06999.x. PMC 398079. PMID 7530656.
  18. ^ Romero F, Dargemont C, Pozo F, Reeves WH, Camonis J, Gisselbrecht S, Fischer S (January 1996). "p95vav associates with the nuclear protein Ku-70". Mol. Cell. Biol. 16 (1): 37–44. doi:10.1128/mcb.16.1.37. PMC 230976. PMID 8524317.
  19. ^ Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A (June 2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells". Biochem. J. 356 (Pt 2): 461–71. doi:10.1042/0264-6021:3560461. PMC 1221857. PMID 11368773.
  20. ^ Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (August 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. doi:10.1021/bi025554o. PMID 12186560.
  21. ^ Raab M, da Silva AJ, Findell PR, Rudd CE (February 1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155–64. doi:10.1016/s1074-7613(00)80422-7. PMID 9047237.
  22. ^ Onodera H, Motto DG, Koretzky GA, Rothstein DM (September 1996). "Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase". J. Biol. Chem. 271 (36): 22225–30. doi:10.1074/jbc.271.36.22225. PMID 8703037.
  23. ^ a b Bertagnolo V, Marchisio M, Volinia S, Caramelli E, Capitani S (Dec 1998). "Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells". FEBS Lett. 441 (3): 480–4. doi:10.1016/s0014-5793(98)01593-2. PMID 9891995. S2CID 38371954.
  24. ^ Hehner SP, Li-Weber M, Giaisi M, Dröge W, Krammer PH, Schmitz ML (April 2000). "Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells". J. Immunol. 164 (7): 3829–36. doi:10.4049/jimmunol.164.7.3829. PMID 10725744.
  25. ^ Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM (June 1999). "Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions". Mol. Cell. 3 (6): 729–39. doi:10.1016/S1097-2765(01)80005-8. PMID 10394361.
  26. ^ Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
  27. ^ Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A (Dec 1996). "Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product". Immunity. 5 (6): 591–604. doi:10.1016/s1074-7613(00)80273-3. PMID 8986718.