Zeki ARI | Celal Bayar University (original) (raw)

Papers by Zeki ARI

Annals of Ophthalmology, 2002

Asian Journal of Surgery, 2009

Leptin has physiological roles in multiple systems, and has possible effects on several carcinoge... more Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients.Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation.Serum leptin levels of TPC patients were higher than in control group subjects (21.15 ± 14.12 ng/mL vs. 9.89 ± 0.21 ng/mL, p < 0.05). The leptin levels decreased after total thyroidectomy (13.92 ± 10.55 ng/mL) compared to prethyroidectomy levels (22.94 ± 14.67 ng/mL) in 34 patients who came to the follow-up visit (p < 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group.Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis.

Clinical Biochemistry, 2009

The objective was to examine changes in serum copper (Cu) levels due to thyroid cancer in humans.... more The objective was to examine changes in serum copper (Cu) levels due to thyroid cancer in humans.47 papillary thyroid cancer patients (mean age 41 ± 13 years) who had undergone total thyroidectomy and 37 control subjects (mean age 42 ± 13 years) were included in this study. Serum Cu levels were detected with atomic absorption spectrophotometer.The serum levels of Cu were 131.61 ± 33.9 μg/dL before surgery and 120.81 ± 30.4 μg/dL 20 days after from surgery. These results were compared with control values 105.87 ± 10.68 μg/dL. Pre-and postoperative serum Cu levels were significantly higher when compared to control group (p < 0.05). However, postoperative serum Cu levels were significantly decreased compared to those of pre-op (p < 0.05).Increasing serum levels of Cu in thyroid cancer patients and its decrease after surgery may be linked to the disease conditions. It is suggested that this change; (a) may be used to demonstrate successful cancer surgery and (b) may have implications for a long-term follow-up of thyroid cancer patients.

Scandinavian Journal of Urology and Nephrology, 2002

The aim of this study is to investigate the value of phosphate levels in serum and urine in patie... more The aim of this study is to investigate the value of phosphate levels in serum and urine in patients with recurrent renal stone disease. The patients (n:60) were divided into two groups as first-time stone disease (group 1) and recurrent renal stone disease (group 2). The demographical datas and their historical information were recorded and physical examination was done. The sera and urine for 24 hr were obtained from patients to measure electrolyte levels especially phosphorus. In addition, based on presenting serum phosphate levels, patients were divided into the hypophosphatemia group, less than 2.5 mg/dl; normophosphatemia group, between 2.5-5.2 mg/dl; and hyperphosphatemia group greater than 5.2 mg/dl. The mean age of study group was 45 (21-70) years. Thirty-six patients (60%) were in group 1 and 24 patients (40%) were in group 2. No statistically correlation was found between stone recurrence and phosphate levels both in serum and urine. There was only a statistical association of K levels in 24-hour urine samples between group 1 and 2. There was no significant association between stone recurrence and initial phosphate levels in the serum or in urine. We do not propose to determine phosphate levels routinely in management of patients with stone disease.

To examine the effects of an 8-week walking program on serum lipids, circulation matrix metallopr... more To examine the effects of an 8-week walking program on serum lipids, circulation matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in post-menopausal women. Method: Body weight, percent body fat, body mass index, estimated maximal oxygen consumption, blood lipids, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 concentrations were assessed and their matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 molar ratios were calculated in exercise (n=12) and control (n=12) groups. Exercise group completed an eight-week walking program at moderate (~6.29±0.15km/h; ~62% maximum heart rate reserve) intensity. Results: Significant changes in estimated maximal oxygen consumption, systolic and diastolic blood pressures, body weight, and body mass index (p< .05) were determined in exercise group. However, there were no significant changes in the measured blood lipids (triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations, and matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-1 molar ratio of exercise group, except for a nearly significant change in tissue inhibitor of metalloproteinase-1 level (p= .092). We determined no significant changes in any of the measured parameters in control group. Conclusion: Despite its protective effects against coronary heart disease risks, the duration and intensity of this program is not sufficient to cause significant changes in blood lipids, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations. A higher-intensity, longer-duration program accompanied with diet is proposed. Key Words: Walking, Blood Lipids, circulation matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, Post-Menopausal Women ÖZET Amaç: Sekiz haftalık yürüme programının menopoz sonrası kadınlarda serum lipidleri, matrix metalloproteinase-9 ve metalloproteinase doku inhibitörü-1 üzerine etkisini belirlemek. Metot: Vücut ağırlığı, vücut yağ yüzdesi, beden kütle indeksi, tahmini maksimal oksijen tüketimi, kan lipidleri, matrix metalloproteinase-9, metalloproteinase doku inhibitörü-1 konsantrasyonları egzersiz (n= 12) ve kontrol (n= 12) gruplarında ölçüldü; matrix metalloproteinase-9/metalloproteinase doku inhibitörü-1 molar oranları hesaplandı. Egzersiz grubuna sekiz hafta orta şiddette (~6.29±0.15km/s; ~%62 maksimum kalp atım sayısı rezervi) bir yürüme programı uygulandı. Bulgular: Egzersiz grubunda tahmini maksimal oksijen tüketimi, sistolik ve diastolik kan basınçları, vücut ağırlığı, ve beden kütle indeksinde anlamlı değişiklikler tespit edildi (p< .05). Fakat, egzersiz grubunun, neredeyse anlamlı metalloproteinase doku inhibitörü-1 düzeyi hariç (p= .092), ölçülen kan lipitlerinde (trigliserit, kolesterol, yüksek yoğunluklu lipoprotein kolesterol, düşük yoğunluklu lipoprotein kolesterol), matrix metalloproteinase-9, metalloproteinase doku inhibitörü-1 değerlerinde ve matrix metalloproteinase-9/metalloproteinase doku inhibitörü-1 molar oranında anlamlı değişikler meydana gelmedi. Sonuç: Kalp hastalıkları riskine karşı koruyucu etkisi hariç, bu programın süre ve şiddeti kan lipidlerinde, matrix metalloproteinase-9 ve metalloproteinase doku inhibitörü-1 değerlerinde anlamlı değişiklikler yaratmak için yeterli olmamıştır. Diyet ile birlikte takip edilecek daha uzun süreli ve şiddeti daha yoğun bir program önerilebilir. . Anahtar Kelimeler: Yürüyüş, Kan lipidleri, matrix metalloproteinase-9, metalloproteinase doku inhibitörü-1, Menopoz sonrası kadınlar Turk J Biochem, 2008; 33 (4) ; 154-162.

To examine the effects of 10-week walking programs on maximal oxygen consumption, body compositio... more To examine the effects of 10-week walking programs on maximal oxygen consumption, body composition, serum lipids, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand. Method: Twenty-seven middle-aged men (40-60years) walked for ten weeks, five days per week, 40-52min per day at either moderate or high intensity (~5.95±0.26km/h and ~7.64±0.36km/h; 50-55% and 70-75% maximum heart rate reserve, respectively). Nonwalking, sedentary men served as controls (n=13). Estimated maximal oxygen consumption, body composition, lipid profile, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand were determined before and after the study. Results: After 10 weeks, estimated maximal oxygen consumption improved in both exercise groups (p<.05), favoring high-intensity group (p<.05). Body weight, percent body fat, and body mass index reduced significantly in both exercise groups (p<.05). Walking programs did not cause any significant changes in blood lipids, highly-sensitive Creactive protein, and osteoprotegerin levels; however, soluble receptor activator of nuclear factor-kappaβ ligand levels were found to decrease in high-intensity group (p<.05) and the change observed in both exercise groups was different from the change in control group (p<.05). Conclusion: For protective effects against cardiac risk factors and arterial calcification, high-intensity walking programs are advisable due to the greater improvements in soluble receptor activator of nuclear factor-kappaβ ligand and estimated maximal oxygen consumption. Key words: Walking exercises, middle-aged men, estimated maximal oxygen consumption, lipid profile, highly-sensitive C-reactive protein, soluble receptor activator of nuclear factor-kappaβ ligand ÖZET Amaç: On haftalık yürüyüş programlarının maksimal oksijen tüketimi, vücut kompozisyonu, serum lipidleri, yüksek sensitiviteli C-reaktif protein, osteoprotegerin ve soluble reseptör aktivatör nükleer faktör-kappaβ ligandı üzerine etkilerini incelemek. Yöntem: Yirmi yedi orta yaşlı (40-60yaş) erkek on hafta, haftada beş gün, günde 40-52 dakika orta veya yüksek şiddette (sırasıyla ~5.95±0.26km/s ve ~7.64±0.36km/s; maksimum kalp atım hızı rezervinin %50-55 ve %70-75'inde) yürüdüler. Yürüyüş yapmayanlar kontrol grubunu oluşturdu (n=13). Egzersiz programı öncesi ve sonrasında, tahmini maksimal oksijen tüketimi, vücut kompozisyonu, lipid profili, yüksek sensitiviteli C-reaktif protein, osteoprotegerin ve soluble reseptör aktivatör nükleer faktör-kappaβ ligandı düzeyleri belirlendi. Bulgular: On haftanın sonunda tahmini maksimal oksijen tüketimi yüksek-şiddet grubunun lehine (p<.05) her iki egzersiz grubunda arttı (p<.05). Vücut ağırlığı, vücut yağ yüzdesi ve beden kitle indeksi değerlerinde egzersiz gruplarında anlamlı azalmalar meydana geldi (p<.05). Yürüyüş antrenmanları kan lipit değerleri, yüksek sensitiviteli C-reaktif protein ve osteoprotegerin düzeyleri üzerinde etkili bulunmadı, ancak soluble reseptör aktivatör nükleer faktör-kappaβ ligand yüksek şiddet grubunda anlamlı olarak azaldı (p<.05); egzersiz gruplarında belirlenen değişim kontrol grubundaki değişimden farklıydı (p<.05). Sonuç: Soluble reseptör aktivatör nükleer faktör-kappaβ ligand ve tahmini maksimal oksijen tüketiminde meydana gelen gelişmelerden dolayı kardiyak risk faktörlerine ve damarsal kalsifikasyona karşı koruyucu etkiler yaratabilmek için yüksek şiddet yürüme programları önerilebilir. Anahtar Kelimeler: Yürüyüş egzersizi, orta yaşlı erkek, tahmini maksimal oksijen tüketimi, lipit profili, yüksek sensitiviteli C-reaktif protein, osteoprotegerin, soluble reseptör aktivatör nükleer faktör-kappaβ ligandı

Cell Biochemistry and Function, 2005

Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropy... more Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long-term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell-specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5 × 1 cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham-operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild ( + ) eNOS expression was observed in all specimens. Mild ( + ) iNOS expression was only detected in ipsilateral testis of the mesh-implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long-term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright © 2004 John Wiley & Sons, Ltd.

International Journal of Neuroscience, 2004

The aim of the study was to investigate the effect of regular exercise on maximum oxygen uptake c... more The aim of the study was to investigate the effect of regular exercise on maximum oxygen uptake capacity (VO2max), reaction time (RT), testosterone (T), growth hormone (GH), insulin-like growth factor-I (IGF-I) in athletes compared to sedentary controls. VO2max, RT, T, GH, and IGF-I levels were 31.2 +/- 6.2 ml/min/kg, 106.7 +/- 23.2 s, 8.3 +/- 1.3 ng/mL, 1.6 +/- 0.7 ng/mL, 106.5 +/- 27.0 ng/mL in master athlete group and 18.8 +/- 5.1 ml/min/kg, 148.3 +/- 39.3 s, 5.4 +/- 1.7 ng/mL, 0.8 +/- 0.3 ng/mL, 90.2 +/- 23.8 ng/mL in sedentary control group, respectively. The differences between regularly exercising males and the control group of sedentary males were found to be statistically significant. The results showed that long-term exercise decreased RT and increased VO2max, T, and GH in elderly males; elevated serum T and GH levels may be advantageous for brain functions.

Clinical Chemistry and Laboratory Medicine, 2002

Psoriasis is characterized by defects in the normal cycle of epidermal development that lead to e... more Psoriasis is characterized by defects in the normal cycle of epidermal development that lead to epidermal hyperproliferation, altered maturation of skin cells, vascular changes and inflammation. Also, psoriasis has been associated with an abnormal plasma lipid metabolism. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients. We determined serum concentrations of lipids, lipoproteins and apolipoprotein Al and B (apo A1 and apo B) in 72 patients with psoriasis and 30 age matched controls. Serum lipoprotein (a) (Lp(a)), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and other biochemical parameters by enzymatic methods. Serum Lp(a) and triglyceride (TG) were significantly higher in patients with psoriasis than in healthy control subjects (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01 for both). Apo B was also found to be higher in the patient group, but the difference was not significant. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apo A1 did not differ significantly from those of the controls. These observations imply that serum Lp(a) and TG concentrations may play a role as risk factors for atherosclerotic disease in patients with psoriasis.

Cardiology in The Young, 2010

Coarctation of the aorta is associated with increased risk for hypertension in adulthood, despite... more Coarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood.

Angiology, 2006

Leptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in at... more Leptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in atherosclerotic lesions in human coronary atherosclerosis. However, the relation of serum leptin concentrations to ischemic heart disease (IHD) is still obscure. The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations. For this purpose, 35 patients with CSAP, 40 with acute STEMI, and 30 control subjects with normal findings from coronary angiography were taken into the study prospectively. Serum leptin concentrations were significantly higher in patients with CSAP and STEMI compared to the control group (7.74 +/-1.34 vs 6.37 +/-1.85 ng/mL, p=0.021 and 8.22 +/-3.13 vs 6.37 +/-1.85 ng/mL, p=0.023, respectively). In addition, serum homocysteine concentrations were significantly increased in patients with CSAP (15.23 +/-5.96 vs 11.40 +/-2.11 micromol/L, p=0.025) and patients with STEMI (15.90 +/-5.02 vs 11.40 +/-2.11 micromol/L, p=0.012) compared to the control group. Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 +/-1.39 vs 3.45 +/-1.19 g/L, p=0.025). No significant correlation was found between leptin levels and selected risk factors. In conclusion, serum leptin concentrations were significantly higher in both the CSAP and STEMI groups. However, owing to the lack of correlation between the leptin levels and selected classical coronary risk factors, it may be considered that leptin can be evaluated as one of the independent risk factors for IHD. Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis.

International Journal of Neuroscience, 2001

The relationship between serum testosterone level and nonverbal intelligence was studied in right... more The relationship between serum testosterone level and nonverbal intelligence was studied in right-handed young adults. Hand preference was assessed by the Edinburgh Handedness Inventory. Serum testosterone level was determined using tritium-marked-radioimmunoassay. Only in men, nonverbal intelligence (Cattell's Culture Fair Intelligence Test) was found to be significantly and directly related to serum testosterone levels. It was concluded that the serum testosterone in young adults is associated with nonverbal intelligence exhibiting fundamental differences between men and women.