Muhammad Salman | COMSATS Institute of Information Technology (original) (raw)

Papers by Muhammad Salman

Research paper thumbnail of Evaluation Of Chronic Kidney Disease And Medication Prescribing Patterns In A Single Tertiary Care Center In Malaysia

Penyakit buah pinggang kronik merupakan masalah perubatan sejagat yang semakin meningkat, ia menj... more Penyakit buah pinggang kronik merupakan masalah perubatan sejagat yang semakin meningkat, ia menjejaskan sosioekonomi keluarga pesakit dan juga negara, maklumat berkenaan punca penyakit tersebut dan corak preskripsi ubat-ubatan yang diperlukan untuk memperbaiki hasil klinikal jarang didapati di Malaysia. Chronic kidney disease (CKD) is an escalating medical problem worldwide, effecting socioeconomic conditions of patient’s family and country, and information about its etiologies and medication prescribing patterns, needed to improve a better clinical outcome, is sparse in Malaysia

Research paper thumbnail of Ameliorative Effects of Propolis Extract on Some Biochemical and Hematological Parameters of Burnt Skin of Male Guinea pigs

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2017

Burns led to insufficient blood volume, ischemia, and body damage caused by ischemic reperfusion.... more Burns led to insufficient blood volume, ischemia, and body damage caused by ischemic reperfusion. Burns can cause many changes in the systemic response-; the metabolic changes represent an important one among systemic response (Hettiaratchy et al., 2004). The antioxidant system of tissues is damaged by injury and cannot cope against reactive oxygen species (ROS) in the following period (Dubick et al., 2002). However, burn wound healing still remains a challenge to modern medicine. Methods such as sap therapy, wound cure, skin graft, and nutrition need simultaneous treatment because burn can lead to serious complications (Zhang et al., 2011).

Research paper thumbnail of Surveillance of Crimean-Congo haemorrhagic fever in Pakistan

The Lancet Infectious Diseases, 2017

Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease that has been reported acro... more Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease that has been reported across Asia, Africa, eastern Europe, the Balkans, and the Middle East. In Pakistan, the first case of CCHF was documented in 1976 and its prevalence has been vigorously debated since. 1 Findings from some studies have associated the incidence of CCHF in Pakistan with the coinciding event of Eid

Research paper thumbnail of Big Data Management in Drug–Drug Interaction: A Modern Deep Learning Approach for Smart Healthcare

Big Data and Cognitive Computing, 2022

The detection and classification of drug–drug interactions (DDI) from existing data are of high i... more The detection and classification of drug–drug interactions (DDI) from existing data are of high importance because recent reports show that DDIs are among the major causes of hospital-acquired conditions and readmissions and are also necessary for smart healthcare. Therefore, to avoid adverse drug interactions, it is necessary to have an up-to-date knowledge of DDIs. This knowledge could be extracted by applying text-processing techniques to the medical literature published in the form of ‘Big Data’ because, whenever a drug interaction is investigated, it is typically reported and published in healthcare and clinical pharmacology journals. However, it is crucial to automate the extraction of the interactions taking place between drugs because the medical literature is being published in immense volumes, and it is impossible for healthcare professionals to read and collect all of the investigated DDI reports from these Big Data. To avoid this time-consuming procedure, the Information...

Research paper thumbnail of The psychological effects of COVID-19 on frontline healthcare workers and how they are coping: a web-based, cross-sectional study from Pakistan

BackgroundHigh level stress is expected when crises starts affecting people’s lives and communiti... more BackgroundHigh level stress is expected when crises starts affecting people’s lives and communities which is witnessed in the past epidemics. Infectious diseases outbreaks like the ongoing COVID19 pandemic have negative impact on healthcare workers’ (HCWs) mental health, which needs to be investigated. Therefore, we aimed to assess the psychological impact of COVID-19 on frontline HCWs and their coping strategies.MethodsA web-based, cross-sectional study was conducted among HCWs of the Punjab province of Pakistan. The generalized anxiety scale (GAD-7), patient health questionnaire (PHQ-9) and Brief-COPE were used to assess anxiety, depression and coping strategies.ResultsThe mean age of respondents (N = 398) was 28.67 ± 4.15 years, with majority of medical doctors (52%). The prevalence of anxiety and depression were 21.4% and 21.9%, respectively. There was no significant difference of anxiety and depression scores among doctors, nurses and pharmacists. Females had significantly high...

Research paper thumbnail of Awareness of H1N1 influenza among Pakistani pharmacy students

Russian Open Medical Journal, 2020

Aim — This study was aimed to investigate knowledge and attitudes of H1N1 influenza among pharmac... more Aim — This study was aimed to investigate knowledge and attitudes of H1N1 influenza among pharmacy students. Material and Methods — A cross-sectional study was carried out among undergraduate and postgraduate students of the Punjab University College of Pharmacy, University of the Punjab, Lahore from February-May 2018. A self-administered questionnaire was used to evaluate knowledge and attitudes of H1N1 influenza. All data were analyzed using SPSS 22. Results — The median age of study participants (N=420) was 20 years, with majority of females (72.4%), undergraduate students (96.7%) belonging to middle economic class (89.8%). The median knowledge score was 18, with 38.1% having poor, 55.7% moderate and 6.2% excellent knowledge score (score <17, 17-25, and 26-34, respectively). The median attitude score was 47 (9); around 52% of the participants were found to have positive attitudes. Initially, there was a significant difference of knowledge score, not attitude, among age categor...

Research paper thumbnail of Novel coronavirus outbreak in Pakistan: Beware of dengue

Journal of the Formosan Medical Association, 2021

The novel coronavirus (COVID-19) pandemic originated in Wuhan, China has become a serious public ... more The novel coronavirus (COVID-19) pandemic originated in Wuhan, China has become a serious public health crisis for the developed and developing world. As of July 07, 2020, a total of 11,748,782 confirmed cases including 540,858 deaths have been reported across the globe. 1 The COVID-19 toll in Pakistan is expanding since its first detection on 26 February 2020, now reached at 234,509 laboratory confirmed cases including 4839 deaths as of July 07, 2020. 1 Importantly, Pakistan is endemic for dengue virus for the last 30 years. According to the Ministry of National Health Services, Regulations and Coordination, the number of dengue cases spiked by almost 15 fold from 3204 cases in 2018 to 47,120 cases in 2019, however the actual number is presumed to be much higher than reported. 2 Likewise, in 2020, 416 confirmed dengue cases appeared much earlier than the post-monsoon peak season. 3 The unusual early appearance of dengue in Pakistan further calls for actions and early response to this outbreakprone disease known to played havoc in Pakistan accounting for 90,400 cases and 169 deaths between 2015 and 2019. Countries with fragile healthcare systems like Pakistan need to prioritize regular and consistent disease surveillance and prevention programs including a central epidemic control center utilizing the modern technological support to detect, track and manage infections early on. For many countries, the COVID-19 outbreak set the stage for self-evaluation of their healthcare systems. The peak of COVID-19 outbreak in Pakistan is forecasted to occur by July, 4 the appearance of dengue cases in May has further deteriorated the situation indicating an overwhelmed needs for surveillance and case management in terms of hospital capacity and vector control measures. An important factor for efficient disease management involves the understanding of clinical manifestations to differentiate between COVID-19 and dengue reported with overlapping clinical presentations in diseased individuals including fever, headache, muscular aches etc.

Research paper thumbnail of How Prepared Was Pakistan for the COVID-19 Outbreak?

Disaster Medicine and Public Health Preparedness, 2020

Research paper thumbnail of Laboratory based surveillance of SARS-CoV-2 in Pakistan

COVID-19 cases are alarmingly increasing in Pakistan since May 2020. Laboratory based surveillanc... more COVID-19 cases are alarmingly increasing in Pakistan since May 2020. Laboratory based surveillance system has been in place since the start of the pandemic. The genomic surveillance of SARS-CoV-2 strains isolated locally has been conducted based on partial ORF1b. The sequences were classified to show the phylogenetic correlation and showed 100% homology with those detected in neighboring countries India and China. The rapid increase in cases has led to development of robust strategies to enhance the laboratory testing capacity. We are currently meeting the country requirement to diagnose the virus in the community. Nonetheless, factors like recent ease in lockdown measures has led to massive rise in number of cases in few weeks time.

Research paper thumbnail of A Biochemical Study on the Effects of Fullerene C60 and Fruit Extract of Balanites aegyptica Plant in Ameliorating the Toxicity Induced by Doxorubicin in Streptozotocin Model of Diabetic Male Albino Rats

Journal of Clinical Toxicology, 2019

There were relationship between hyperglycaemic and pharmakinetic of toxicity of doxorubicin that ... more There were relationship between hyperglycaemic and pharmakinetic of toxicity of doxorubicin that lead to increase oxidative stress on cells. This study was aimed to detect the curative effect of some antioxidants drugs (fullerene C 60 and mesocarp fruit extract of Balanites aegyptaica) on the haematological and biochemical of kidney function parameters after induced by diabetes and toxicity with doxorubicin on the rats. Nine groups of adult male albino rats were established (n=8). The first group (Group 1) was served as normal group. Group 2 was injected intraperitoneal (i.p) with by streptozotocin at single dose (45 mg/kg body weight). Diabetic rats (Group 3) were injected intraperitoneal (i.p) with doxorubicin at dose (5 mg/kg body weight) for three days. Diabetic rats (Group 4) were given orally fullerene C 60 daily at dose (4 mg/kg body weight). Diabetic rats (Group 5) treated orally by mesocarp fruit extract of Balanites aegyptaica at dose (1.5 ml/kg body weight). (Group 6) treated orally with fullerene C 60 plus mesocarp fruit extract of Balanites aegyptaica. Diabetic rats (Group 7) intoxicated DOX treated orally with fullerene C 60. Diabetic rats (Group 8) intoxicated DOX treated orally with mesocarp fruit extract of Balanites aegyptaica. Diabetic rats (Group 9) diabetic rats treated orally with fullerene C 60 plus mesocarp fruit extract of Balanites aegyptaica. Whole blood and serum were collected for haematological and biochemical of kidney functions examinations, respectively. Diabetes induce, hematotoxicity was determined by a highly significant decrease in Red Blood Cells (RBCs), White Blood Cells (WBCs), Blood Platelets (PLTs), Haemoglobin (Hb) and PCV value, as well as nephropathy was determined by a highly significant increase in creatinne, urea and uric acid. Diabetic rats intoxicated DOX showed reduction in haematological parameters, also, there were highly significant increases in kidney function parameters. Fullerene C 60 and mesocarp fruit extract of Balanites aegyptaica ameliorated haematological and kidney functions indices. It could be concluded that Fullerene C 60 and Balanites aegyptiaca, clarified a modulatory role against the cellular damage produced by oxidative stress.

Research paper thumbnail of Evaluation of medication use in Malaysian predialysis patients

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

Chronic kidney disease (CKD) patients suffer from multiple comorbidities and complications as a c... more Chronic kidney disease (CKD) patients suffer from multiple comorbidities and complications as a cause or consequence of kidney disease. Information regarding medication- prescribing patterns in predialysis patients is sparse. We conducted a retrospective study to evaluate the medication prescription patterns among predialysis patients. Medical records (both paper based and computerized) of patients at CKD Resource Centre, Hospital Universiti Sains Malaysia, were reviewed. A total of 615 eligible cases were included in the study. The mean number of medications prescribed per patient was 8.22 ± 2.81, and medication use was correlated to the renal function (stage 3a < stage 3b < stage 4 < stage 5; P <0.001). The top three prescribed medication groups were found to be lipid-lowering agents, calcium channel blockers, and antiplatelet agents. Some medication classes such as nonaluminum/noncalcium phosphate binders, erythropoietin-stimulating agents, and renin-angiotensin-aldos...

Research paper thumbnail of Comparative Effects of Scorpion Venom and Aqueous Basil (Ocimum basilicum) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats

Journal of Liver, 2016

The aim of this work was to highlight the reverse effect of BPF and O. basilicum against the toxi... more The aim of this work was to highlight the reverse effect of BPF and O. basilicum against the toxicity of CCl 4 on albino rats, and also to compare the curative effect of bradykinin potentiating factor on CCl 4induced toxicity in albino rats with that of O. basilicum extract.

Research paper thumbnail of Psychological Impact of COVID-19 on Pakistani University Students and How They Are Coping

BackgroundCOVID-19 is spreading quickly, causing great deal of fear and unrest in the public. We ... more BackgroundCOVID-19 is spreading quickly, causing great deal of fear and unrest in the public. We aimed to assess the psychological impact of COVID-19 on university students and their coping strategies.MethodsThis web-based, cross-sectional study was conducted among students of four Pakistani higher education institutions. Google forms were used to disseminate the online questionnaire to assess anxiety (GAD-7), depression (PHQ-9), sources of distress (14-items) and the coping strategies (Brief-COPE).ResultsA total of 1134 responses (age 21.7 ± 3.5 years) were included. The frequency of students having moderate-severe anxiety and depression (score ≥ 10) were ≈ 34% and 45%, respectively. The respondents’ aged ≥ 31 years had significantly lower depression score than those below 30 years. Males had significantly less anxiety and depression scores than females. Additionally, those having a family member, friend or acquaintance infected with the disease had significantly higher anxiety sco...

Research paper thumbnail of Design and Implementation of an Autonomous Car for Navigation in Unknown Enviornments

ABSTRACT The paper describes the design and implementation of an intelligent autonomous vehicle t... more ABSTRACT The paper describes the design and implementation of an intelligent autonomous vehicle that can navigate without human operator in unknown environments. Equipped with ultrasonic sensors and GPS receiver, the vehicle can reach the destination by avoiding the obstacles in its way and followings the lanes on roads. Ultrasonic sensor and GPS are interfaced to AT89C52 microcontroller which implements hurdle avoidance and goal reaching behavior at low level while camera is interfaced to pc for road following task at higher level. The designed vehicle has modular structure and more modules can be added without much complexity.

Research paper thumbnail of Synthesis, characterization and study of antibacterial activity of enaminone complexes of zinc and iron

Arabian Journal of Chemistry, 2010

Complexes of enaminones; 4-N,N-diethylamine-pent-3-ene-2-one [HL 1 ], 4-N,N-di n-propylamine-pent... more Complexes of enaminones; 4-N,N-diethylamine-pent-3-ene-2-one [HL 1 ], 4-N,N-di n-propylamine-pent-3-ene-2-one [HL 2 ] and 4-N,N-dicyclohexylamine-pent-3-ene-2-one [HL 3 ] with Fe(II) and Zn(II) ions were prepared by reacting the equimolar ethanolic solutions of the ligands (HL 1 , HL 2 and HL 3) with ethanolic metal solutions. The complexes formed, were characterized by infrared, ultraviolet and atomic absorption spectroscopy. Ligands and their metal complexes were tested against Escherichia coli and Staphylococcus aureus bacteria to assess their antibacterial action using disc diffusion method. Ligands were completely inactive against bacteria whereas the complex Zn (HL 1) has significant action on both bacteria, indicating that it has a good potential as bactericide. Other complexes have normal antiseptic character.

Research paper thumbnail of Removal of Alizarin Red S (Dye) from Aqueous Media by using Alumina as an Adsorbent

Journal of the Chemical …, 2011

RABIA REHMAN, TARIQ MAHMUD*, JAMIL ANWAR, MUHAMMAD SALMAN, UMER SHAFIQUE, WAHEED-UZ-ZAMAN AND FUR... more RABIA REHMAN, TARIQ MAHMUD*, JAMIL ANWAR, MUHAMMAD SALMAN, UMER SHAFIQUE, WAHEED-UZ-ZAMAN AND FURQAN ALI Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan. ... (Received on 24th May 2010, accepted in revised ...

Research paper thumbnail of Sustainable Materialization of Residues from Thermal Processes into Products-SMaRT-Pro²

Sustainable use of solid residues and carbon dioxide, the two largest and most important waste pr... more Sustainable use of solid residues and carbon dioxide, the two largest and most important waste products from thermal processes, is an urgent issue both for the industry involved and society as a whole, considering the financial and environmental repercussions of their production. This Knowledge Platform focuses on three types of waste-to-product valorisation: production of a carbon sink, construction materials, or sorbents. Thermal processes are widely applied in metals and cement production, waste incineration, etc. They produce major amounts of solid waste materials, such as slag and fly ash, and generate a vast amount of carbon dioxide. Mineral carbon sequestration in alkaline waste materials is a feasible solution because of high reactivity, on-site production, waste stabilization and low cost. Turning waste into construction materials is another route for transforming low-cost input materials into potentially high-value products. The production of a sorbent for wastewater and flue gas treatment is another promising industrial option for in-house treatment of waste streams. A successful approach requires a broad consortium with relevant expertise for the scientific investigation, but which at the same time can be easily tailored to a particular valorisation option that emerges. The Platform aims at this dual objective by bringing together all parties and by focusing on the challenging aim of valorising thermal process wastes into high-value products by intensified processes and with clear prospects on the economic and legislative feasibility, ecological benefits and societal relevance.

Research paper thumbnail of Floral diversity of District Bagh, Azad Jammu and Kashmir Pakistan

Universal Journal of Plant Science

The study showed the floral diversity and variation in the structure of vegetation in District Ba... more The study showed the floral diversity and variation in the structure of vegetation in District Bagh, AJ&K. A total of 200 plants belong to 65 families and 170 genera were documented from seven localities. The most species richest site was found Mahmood Galli with 101 species (dicots 55, monocots 35, pteridophytes 10 and gymnosperm 1) followed by Toliper 100 spp. (dicots 55, monocots 31, pteridophytes 13 and gymnosperms 1), Lasdana, 85 spp. (dicots 47, monocots 35, pteridophytes 6 and gymnosperms 2), Plungi 81spp. (dicots 51, monocots13, pteridophytes 16 and gymnosperm 1), Khurshidabad, 74 spp. (dicots 34, monocots 21, pteridophytes 19), Kahutta, 70 spp. (dicots 36, monocots 15, pteridophytes 19) and Kiran 46 Spp. dicots 34, gymnosperm 3). Among pteridophytes, Polystichum squarrosum had highest distribution percentage 85.71 % while Lepisorus clathratus and Pyrrosia mollis have least percentage distribution 4.28 %. Among gymnosperms, Pinus wallichiana had highest distribution percentage 57.14 % while Cedrus deodara and Pinus roxburgii have least distribution percentage 14.28. Aristida abnormis had highest distribution percentage with 71.42 % while Zizania aquatica and Themeda anathera have least distribution percentage with 14.28 %. In dicots, Amaranthus viridis, Amaranthus spinosus and Cucumis sativus had highest distribution percentage with 85.71 % and Oxalis corniculata, Quercus incana and Fragaria nubicola had least frequency with 14.28 %. Species diversity was high in the tree layer in the middle part of the altitudinal gradient. It decreases both towards upper and lower altitude, which was due to deforestation, human interaction, encroachment pressure, low number of species and soil erosion.

Research paper thumbnail of Physiological effects of envenomation by two different doses of the viper Echis coloratusis crude venom on biochemical parameters in serum of Guinea pigs at different times

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

The eastern carpet viper Echis coloratusis widely distributed from Africa (eastern Egypt). In the... more The eastern carpet viper Echis coloratusis widely distributed from Africa (eastern Egypt). In the present study the effects of crude venom of the viper Echis coloratusis on serum biochemical parameters of guinea pigs. Adult male guinea pigs (550 ± 25 g body weigh) were divided into three groups (15 each). In the control group, guinea pigs were interaperitoneally (i.p) injected with 50 µL saline solution. The second group was i.p. injected with 0.1µgm/g b.w. of crude venom in 50 µL saline solutions. The third group was i.p. injected with 0.2 µgm/g. b.w. of the crude venom in 50 µL saline solution. The results indicated that the injection of crude venom of the viper Echis coloratusis induced a significant decrease in total serum protein, albumin, globulin and uric acid within 1, 2 and 4 hrs. after injection. In contrast, the levels of glucose, cholesterol, triglycerides, urea and creatinine were increased significantly in envenomated Guinea pigs. Viper Echis coloratusis crude venom caused hepatic and renal dysfunction in envenomated Guinea pigs.

Research paper thumbnail of The Influence of Ownership Structure and Audit Committee on Income Management with Independent Board of Commissioners 'Proportion as Moderating Variables in Infrastructure, Utility and Transportation Companies Registered on the Idx

JIM UPB (Jurnal Ilmiah Manajemen Universitas Putera Batam)

The purpose of this study is to examine the effect of managerial ownership structure, institution... more The purpose of this study is to examine the effect of managerial ownership structure, institutional ownership structure and audit committee on earnings management with the proportion of independent board of commissioners as a moderating variable. The samples in this study are infrastructure, utility and transportation companies listed on the Indonesia Stock Exchange (BEI) 2009. -2018 6 companies were selected using purposive sampling method. The result of the multiple linear regression equation is Y = -0,827 + 0,007 X1 + 0,006 X2 + 0,121 X3 + 0,032 M + 0,006 X1.M + 0,011 X2.M - 0,675 X3.M. The results showed that ownership structure, institutional ownership structure, audit committee and the proportion of independent commissioners did not have a significant effect on partial earnings management. Based on the partially moderated regression analysis test, the proportion of independent board of commissioners cannot moderate the effect of managerial ownership structure on earnings manag...

Research paper thumbnail of Evaluation Of Chronic Kidney Disease And Medication Prescribing Patterns In A Single Tertiary Care Center In Malaysia

Penyakit buah pinggang kronik merupakan masalah perubatan sejagat yang semakin meningkat, ia menj... more Penyakit buah pinggang kronik merupakan masalah perubatan sejagat yang semakin meningkat, ia menjejaskan sosioekonomi keluarga pesakit dan juga negara, maklumat berkenaan punca penyakit tersebut dan corak preskripsi ubat-ubatan yang diperlukan untuk memperbaiki hasil klinikal jarang didapati di Malaysia. Chronic kidney disease (CKD) is an escalating medical problem worldwide, effecting socioeconomic conditions of patient’s family and country, and information about its etiologies and medication prescribing patterns, needed to improve a better clinical outcome, is sparse in Malaysia

Research paper thumbnail of Ameliorative Effects of Propolis Extract on Some Biochemical and Hematological Parameters of Burnt Skin of Male Guinea pigs

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2017

Burns led to insufficient blood volume, ischemia, and body damage caused by ischemic reperfusion.... more Burns led to insufficient blood volume, ischemia, and body damage caused by ischemic reperfusion. Burns can cause many changes in the systemic response-; the metabolic changes represent an important one among systemic response (Hettiaratchy et al., 2004). The antioxidant system of tissues is damaged by injury and cannot cope against reactive oxygen species (ROS) in the following period (Dubick et al., 2002). However, burn wound healing still remains a challenge to modern medicine. Methods such as sap therapy, wound cure, skin graft, and nutrition need simultaneous treatment because burn can lead to serious complications (Zhang et al., 2011).

Research paper thumbnail of Surveillance of Crimean-Congo haemorrhagic fever in Pakistan

The Lancet Infectious Diseases, 2017

Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease that has been reported acro... more Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease that has been reported across Asia, Africa, eastern Europe, the Balkans, and the Middle East. In Pakistan, the first case of CCHF was documented in 1976 and its prevalence has been vigorously debated since. 1 Findings from some studies have associated the incidence of CCHF in Pakistan with the coinciding event of Eid

Research paper thumbnail of Big Data Management in Drug–Drug Interaction: A Modern Deep Learning Approach for Smart Healthcare

Big Data and Cognitive Computing, 2022

The detection and classification of drug–drug interactions (DDI) from existing data are of high i... more The detection and classification of drug–drug interactions (DDI) from existing data are of high importance because recent reports show that DDIs are among the major causes of hospital-acquired conditions and readmissions and are also necessary for smart healthcare. Therefore, to avoid adverse drug interactions, it is necessary to have an up-to-date knowledge of DDIs. This knowledge could be extracted by applying text-processing techniques to the medical literature published in the form of ‘Big Data’ because, whenever a drug interaction is investigated, it is typically reported and published in healthcare and clinical pharmacology journals. However, it is crucial to automate the extraction of the interactions taking place between drugs because the medical literature is being published in immense volumes, and it is impossible for healthcare professionals to read and collect all of the investigated DDI reports from these Big Data. To avoid this time-consuming procedure, the Information...

Research paper thumbnail of The psychological effects of COVID-19 on frontline healthcare workers and how they are coping: a web-based, cross-sectional study from Pakistan

BackgroundHigh level stress is expected when crises starts affecting people’s lives and communiti... more BackgroundHigh level stress is expected when crises starts affecting people’s lives and communities which is witnessed in the past epidemics. Infectious diseases outbreaks like the ongoing COVID19 pandemic have negative impact on healthcare workers’ (HCWs) mental health, which needs to be investigated. Therefore, we aimed to assess the psychological impact of COVID-19 on frontline HCWs and their coping strategies.MethodsA web-based, cross-sectional study was conducted among HCWs of the Punjab province of Pakistan. The generalized anxiety scale (GAD-7), patient health questionnaire (PHQ-9) and Brief-COPE were used to assess anxiety, depression and coping strategies.ResultsThe mean age of respondents (N = 398) was 28.67 ± 4.15 years, with majority of medical doctors (52%). The prevalence of anxiety and depression were 21.4% and 21.9%, respectively. There was no significant difference of anxiety and depression scores among doctors, nurses and pharmacists. Females had significantly high...

Research paper thumbnail of Awareness of H1N1 influenza among Pakistani pharmacy students

Russian Open Medical Journal, 2020

Aim — This study was aimed to investigate knowledge and attitudes of H1N1 influenza among pharmac... more Aim — This study was aimed to investigate knowledge and attitudes of H1N1 influenza among pharmacy students. Material and Methods — A cross-sectional study was carried out among undergraduate and postgraduate students of the Punjab University College of Pharmacy, University of the Punjab, Lahore from February-May 2018. A self-administered questionnaire was used to evaluate knowledge and attitudes of H1N1 influenza. All data were analyzed using SPSS 22. Results — The median age of study participants (N=420) was 20 years, with majority of females (72.4%), undergraduate students (96.7%) belonging to middle economic class (89.8%). The median knowledge score was 18, with 38.1% having poor, 55.7% moderate and 6.2% excellent knowledge score (score <17, 17-25, and 26-34, respectively). The median attitude score was 47 (9); around 52% of the participants were found to have positive attitudes. Initially, there was a significant difference of knowledge score, not attitude, among age categor...

Research paper thumbnail of Novel coronavirus outbreak in Pakistan: Beware of dengue

Journal of the Formosan Medical Association, 2021

The novel coronavirus (COVID-19) pandemic originated in Wuhan, China has become a serious public ... more The novel coronavirus (COVID-19) pandemic originated in Wuhan, China has become a serious public health crisis for the developed and developing world. As of July 07, 2020, a total of 11,748,782 confirmed cases including 540,858 deaths have been reported across the globe. 1 The COVID-19 toll in Pakistan is expanding since its first detection on 26 February 2020, now reached at 234,509 laboratory confirmed cases including 4839 deaths as of July 07, 2020. 1 Importantly, Pakistan is endemic for dengue virus for the last 30 years. According to the Ministry of National Health Services, Regulations and Coordination, the number of dengue cases spiked by almost 15 fold from 3204 cases in 2018 to 47,120 cases in 2019, however the actual number is presumed to be much higher than reported. 2 Likewise, in 2020, 416 confirmed dengue cases appeared much earlier than the post-monsoon peak season. 3 The unusual early appearance of dengue in Pakistan further calls for actions and early response to this outbreakprone disease known to played havoc in Pakistan accounting for 90,400 cases and 169 deaths between 2015 and 2019. Countries with fragile healthcare systems like Pakistan need to prioritize regular and consistent disease surveillance and prevention programs including a central epidemic control center utilizing the modern technological support to detect, track and manage infections early on. For many countries, the COVID-19 outbreak set the stage for self-evaluation of their healthcare systems. The peak of COVID-19 outbreak in Pakistan is forecasted to occur by July, 4 the appearance of dengue cases in May has further deteriorated the situation indicating an overwhelmed needs for surveillance and case management in terms of hospital capacity and vector control measures. An important factor for efficient disease management involves the understanding of clinical manifestations to differentiate between COVID-19 and dengue reported with overlapping clinical presentations in diseased individuals including fever, headache, muscular aches etc.

Research paper thumbnail of How Prepared Was Pakistan for the COVID-19 Outbreak?

Disaster Medicine and Public Health Preparedness, 2020

Research paper thumbnail of Laboratory based surveillance of SARS-CoV-2 in Pakistan

COVID-19 cases are alarmingly increasing in Pakistan since May 2020. Laboratory based surveillanc... more COVID-19 cases are alarmingly increasing in Pakistan since May 2020. Laboratory based surveillance system has been in place since the start of the pandemic. The genomic surveillance of SARS-CoV-2 strains isolated locally has been conducted based on partial ORF1b. The sequences were classified to show the phylogenetic correlation and showed 100% homology with those detected in neighboring countries India and China. The rapid increase in cases has led to development of robust strategies to enhance the laboratory testing capacity. We are currently meeting the country requirement to diagnose the virus in the community. Nonetheless, factors like recent ease in lockdown measures has led to massive rise in number of cases in few weeks time.

Research paper thumbnail of A Biochemical Study on the Effects of Fullerene C60 and Fruit Extract of Balanites aegyptica Plant in Ameliorating the Toxicity Induced by Doxorubicin in Streptozotocin Model of Diabetic Male Albino Rats

Journal of Clinical Toxicology, 2019

There were relationship between hyperglycaemic and pharmakinetic of toxicity of doxorubicin that ... more There were relationship between hyperglycaemic and pharmakinetic of toxicity of doxorubicin that lead to increase oxidative stress on cells. This study was aimed to detect the curative effect of some antioxidants drugs (fullerene C 60 and mesocarp fruit extract of Balanites aegyptaica) on the haematological and biochemical of kidney function parameters after induced by diabetes and toxicity with doxorubicin on the rats. Nine groups of adult male albino rats were established (n=8). The first group (Group 1) was served as normal group. Group 2 was injected intraperitoneal (i.p) with by streptozotocin at single dose (45 mg/kg body weight). Diabetic rats (Group 3) were injected intraperitoneal (i.p) with doxorubicin at dose (5 mg/kg body weight) for three days. Diabetic rats (Group 4) were given orally fullerene C 60 daily at dose (4 mg/kg body weight). Diabetic rats (Group 5) treated orally by mesocarp fruit extract of Balanites aegyptaica at dose (1.5 ml/kg body weight). (Group 6) treated orally with fullerene C 60 plus mesocarp fruit extract of Balanites aegyptaica. Diabetic rats (Group 7) intoxicated DOX treated orally with fullerene C 60. Diabetic rats (Group 8) intoxicated DOX treated orally with mesocarp fruit extract of Balanites aegyptaica. Diabetic rats (Group 9) diabetic rats treated orally with fullerene C 60 plus mesocarp fruit extract of Balanites aegyptaica. Whole blood and serum were collected for haematological and biochemical of kidney functions examinations, respectively. Diabetes induce, hematotoxicity was determined by a highly significant decrease in Red Blood Cells (RBCs), White Blood Cells (WBCs), Blood Platelets (PLTs), Haemoglobin (Hb) and PCV value, as well as nephropathy was determined by a highly significant increase in creatinne, urea and uric acid. Diabetic rats intoxicated DOX showed reduction in haematological parameters, also, there were highly significant increases in kidney function parameters. Fullerene C 60 and mesocarp fruit extract of Balanites aegyptaica ameliorated haematological and kidney functions indices. It could be concluded that Fullerene C 60 and Balanites aegyptiaca, clarified a modulatory role against the cellular damage produced by oxidative stress.

Research paper thumbnail of Evaluation of medication use in Malaysian predialysis patients

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

Chronic kidney disease (CKD) patients suffer from multiple comorbidities and complications as a c... more Chronic kidney disease (CKD) patients suffer from multiple comorbidities and complications as a cause or consequence of kidney disease. Information regarding medication- prescribing patterns in predialysis patients is sparse. We conducted a retrospective study to evaluate the medication prescription patterns among predialysis patients. Medical records (both paper based and computerized) of patients at CKD Resource Centre, Hospital Universiti Sains Malaysia, were reviewed. A total of 615 eligible cases were included in the study. The mean number of medications prescribed per patient was 8.22 ± 2.81, and medication use was correlated to the renal function (stage 3a < stage 3b < stage 4 < stage 5; P <0.001). The top three prescribed medication groups were found to be lipid-lowering agents, calcium channel blockers, and antiplatelet agents. Some medication classes such as nonaluminum/noncalcium phosphate binders, erythropoietin-stimulating agents, and renin-angiotensin-aldos...

Research paper thumbnail of Comparative Effects of Scorpion Venom and Aqueous Basil (Ocimum basilicum) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats

Journal of Liver, 2016

The aim of this work was to highlight the reverse effect of BPF and O. basilicum against the toxi... more The aim of this work was to highlight the reverse effect of BPF and O. basilicum against the toxicity of CCl 4 on albino rats, and also to compare the curative effect of bradykinin potentiating factor on CCl 4induced toxicity in albino rats with that of O. basilicum extract.

Research paper thumbnail of Psychological Impact of COVID-19 on Pakistani University Students and How They Are Coping

BackgroundCOVID-19 is spreading quickly, causing great deal of fear and unrest in the public. We ... more BackgroundCOVID-19 is spreading quickly, causing great deal of fear and unrest in the public. We aimed to assess the psychological impact of COVID-19 on university students and their coping strategies.MethodsThis web-based, cross-sectional study was conducted among students of four Pakistani higher education institutions. Google forms were used to disseminate the online questionnaire to assess anxiety (GAD-7), depression (PHQ-9), sources of distress (14-items) and the coping strategies (Brief-COPE).ResultsA total of 1134 responses (age 21.7 ± 3.5 years) were included. The frequency of students having moderate-severe anxiety and depression (score ≥ 10) were ≈ 34% and 45%, respectively. The respondents’ aged ≥ 31 years had significantly lower depression score than those below 30 years. Males had significantly less anxiety and depression scores than females. Additionally, those having a family member, friend or acquaintance infected with the disease had significantly higher anxiety sco...

Research paper thumbnail of Design and Implementation of an Autonomous Car for Navigation in Unknown Enviornments

ABSTRACT The paper describes the design and implementation of an intelligent autonomous vehicle t... more ABSTRACT The paper describes the design and implementation of an intelligent autonomous vehicle that can navigate without human operator in unknown environments. Equipped with ultrasonic sensors and GPS receiver, the vehicle can reach the destination by avoiding the obstacles in its way and followings the lanes on roads. Ultrasonic sensor and GPS are interfaced to AT89C52 microcontroller which implements hurdle avoidance and goal reaching behavior at low level while camera is interfaced to pc for road following task at higher level. The designed vehicle has modular structure and more modules can be added without much complexity.

Research paper thumbnail of Synthesis, characterization and study of antibacterial activity of enaminone complexes of zinc and iron

Arabian Journal of Chemistry, 2010

Complexes of enaminones; 4-N,N-diethylamine-pent-3-ene-2-one [HL 1 ], 4-N,N-di n-propylamine-pent... more Complexes of enaminones; 4-N,N-diethylamine-pent-3-ene-2-one [HL 1 ], 4-N,N-di n-propylamine-pent-3-ene-2-one [HL 2 ] and 4-N,N-dicyclohexylamine-pent-3-ene-2-one [HL 3 ] with Fe(II) and Zn(II) ions were prepared by reacting the equimolar ethanolic solutions of the ligands (HL 1 , HL 2 and HL 3) with ethanolic metal solutions. The complexes formed, were characterized by infrared, ultraviolet and atomic absorption spectroscopy. Ligands and their metal complexes were tested against Escherichia coli and Staphylococcus aureus bacteria to assess their antibacterial action using disc diffusion method. Ligands were completely inactive against bacteria whereas the complex Zn (HL 1) has significant action on both bacteria, indicating that it has a good potential as bactericide. Other complexes have normal antiseptic character.

Research paper thumbnail of Removal of Alizarin Red S (Dye) from Aqueous Media by using Alumina as an Adsorbent

Journal of the Chemical …, 2011

RABIA REHMAN, TARIQ MAHMUD*, JAMIL ANWAR, MUHAMMAD SALMAN, UMER SHAFIQUE, WAHEED-UZ-ZAMAN AND FUR... more RABIA REHMAN, TARIQ MAHMUD*, JAMIL ANWAR, MUHAMMAD SALMAN, UMER SHAFIQUE, WAHEED-UZ-ZAMAN AND FURQAN ALI Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan. ... (Received on 24th May 2010, accepted in revised ...

Research paper thumbnail of Sustainable Materialization of Residues from Thermal Processes into Products-SMaRT-Pro²

Sustainable use of solid residues and carbon dioxide, the two largest and most important waste pr... more Sustainable use of solid residues and carbon dioxide, the two largest and most important waste products from thermal processes, is an urgent issue both for the industry involved and society as a whole, considering the financial and environmental repercussions of their production. This Knowledge Platform focuses on three types of waste-to-product valorisation: production of a carbon sink, construction materials, or sorbents. Thermal processes are widely applied in metals and cement production, waste incineration, etc. They produce major amounts of solid waste materials, such as slag and fly ash, and generate a vast amount of carbon dioxide. Mineral carbon sequestration in alkaline waste materials is a feasible solution because of high reactivity, on-site production, waste stabilization and low cost. Turning waste into construction materials is another route for transforming low-cost input materials into potentially high-value products. The production of a sorbent for wastewater and flue gas treatment is another promising industrial option for in-house treatment of waste streams. A successful approach requires a broad consortium with relevant expertise for the scientific investigation, but which at the same time can be easily tailored to a particular valorisation option that emerges. The Platform aims at this dual objective by bringing together all parties and by focusing on the challenging aim of valorising thermal process wastes into high-value products by intensified processes and with clear prospects on the economic and legislative feasibility, ecological benefits and societal relevance.

Research paper thumbnail of Floral diversity of District Bagh, Azad Jammu and Kashmir Pakistan

Universal Journal of Plant Science

The study showed the floral diversity and variation in the structure of vegetation in District Ba... more The study showed the floral diversity and variation in the structure of vegetation in District Bagh, AJ&K. A total of 200 plants belong to 65 families and 170 genera were documented from seven localities. The most species richest site was found Mahmood Galli with 101 species (dicots 55, monocots 35, pteridophytes 10 and gymnosperm 1) followed by Toliper 100 spp. (dicots 55, monocots 31, pteridophytes 13 and gymnosperms 1), Lasdana, 85 spp. (dicots 47, monocots 35, pteridophytes 6 and gymnosperms 2), Plungi 81spp. (dicots 51, monocots13, pteridophytes 16 and gymnosperm 1), Khurshidabad, 74 spp. (dicots 34, monocots 21, pteridophytes 19), Kahutta, 70 spp. (dicots 36, monocots 15, pteridophytes 19) and Kiran 46 Spp. dicots 34, gymnosperm 3). Among pteridophytes, Polystichum squarrosum had highest distribution percentage 85.71 % while Lepisorus clathratus and Pyrrosia mollis have least percentage distribution 4.28 %. Among gymnosperms, Pinus wallichiana had highest distribution percentage 57.14 % while Cedrus deodara and Pinus roxburgii have least distribution percentage 14.28. Aristida abnormis had highest distribution percentage with 71.42 % while Zizania aquatica and Themeda anathera have least distribution percentage with 14.28 %. In dicots, Amaranthus viridis, Amaranthus spinosus and Cucumis sativus had highest distribution percentage with 85.71 % and Oxalis corniculata, Quercus incana and Fragaria nubicola had least frequency with 14.28 %. Species diversity was high in the tree layer in the middle part of the altitudinal gradient. It decreases both towards upper and lower altitude, which was due to deforestation, human interaction, encroachment pressure, low number of species and soil erosion.

Research paper thumbnail of Physiological effects of envenomation by two different doses of the viper Echis coloratusis crude venom on biochemical parameters in serum of Guinea pigs at different times

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

The eastern carpet viper Echis coloratusis widely distributed from Africa (eastern Egypt). In the... more The eastern carpet viper Echis coloratusis widely distributed from Africa (eastern Egypt). In the present study the effects of crude venom of the viper Echis coloratusis on serum biochemical parameters of guinea pigs. Adult male guinea pigs (550 ± 25 g body weigh) were divided into three groups (15 each). In the control group, guinea pigs were interaperitoneally (i.p) injected with 50 µL saline solution. The second group was i.p. injected with 0.1µgm/g b.w. of crude venom in 50 µL saline solutions. The third group was i.p. injected with 0.2 µgm/g. b.w. of the crude venom in 50 µL saline solution. The results indicated that the injection of crude venom of the viper Echis coloratusis induced a significant decrease in total serum protein, albumin, globulin and uric acid within 1, 2 and 4 hrs. after injection. In contrast, the levels of glucose, cholesterol, triglycerides, urea and creatinine were increased significantly in envenomated Guinea pigs. Viper Echis coloratusis crude venom caused hepatic and renal dysfunction in envenomated Guinea pigs.

Research paper thumbnail of The Influence of Ownership Structure and Audit Committee on Income Management with Independent Board of Commissioners 'Proportion as Moderating Variables in Infrastructure, Utility and Transportation Companies Registered on the Idx

JIM UPB (Jurnal Ilmiah Manajemen Universitas Putera Batam)

The purpose of this study is to examine the effect of managerial ownership structure, institution... more The purpose of this study is to examine the effect of managerial ownership structure, institutional ownership structure and audit committee on earnings management with the proportion of independent board of commissioners as a moderating variable. The samples in this study are infrastructure, utility and transportation companies listed on the Indonesia Stock Exchange (BEI) 2009. -2018 6 companies were selected using purposive sampling method. The result of the multiple linear regression equation is Y = -0,827 + 0,007 X1 + 0,006 X2 + 0,121 X3 + 0,032 M + 0,006 X1.M + 0,011 X2.M - 0,675 X3.M. The results showed that ownership structure, institutional ownership structure, audit committee and the proportion of independent commissioners did not have a significant effect on partial earnings management. Based on the partially moderated regression analysis test, the proportion of independent board of commissioners cannot moderate the effect of managerial ownership structure on earnings manag...