Neural Stem Cells for Cns Repair: State of the Art and Future Directions (original) (raw)

Abstract

Approximately 10-15 years ago, we and a small group of other investigators recognized cells with an unanticipated degree of plasticity and multipotency existed in the CNS. These cells are now called neural stem cells (NSCs). They probably represented the cellular basis for a great deal of unrecognized plasticity programmed into the developing and post-developmental CNS. It is likely that therapeutic advantage might be realized by harnessing this plasticity. Two complementary goals drive the motivation to study NSCs both in situ and following their isolation and propagation ex vivo. The first is to understand the processes of commitment, differentiation, migration and plasticity in the mammalian nervous system during development and degeneration. The second is to use such cells for therapeutic purposes (at all ages). The pursuit of one goal typically nurtures the other, and our lab pursues these two overlapping areas of investigation. In fact, our hypothesis has been that, by first understanding the fundamental biology of pluripotent NSCs (whose role is to mediate organogenesis, homeostasis and reconstitution), and then exploiting those novel molecular and/or cellular replacement clinical therapies for some developmental, degenerative and acquired human neurological dysfunctions. In fact, these actual hNSCs may have the potential for direct human application.

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Authors and Affiliations

  1. Departments of Neurosurgery, Pediatrics, and Neurology Children’s Hospital Harvard Medical School Boston, Massachusetts, USA
    Kook In Park, Mahesh Lachyankar, Sahar Nissim & Evan Y. Snyder
  2. Department of Pediatrics, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Kook In Park

Authors

  1. Kook In Park
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  2. Mahesh Lachyankar
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  3. Sahar Nissim
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  4. Evan Y. Snyder
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA
    David A. Sullivan , Darlene A. Dartt & Rose M. Sullivan , &
  2. Harvard Medical School, Boston, Massachusetts, USA
    David A. Sullivan & Darlene A. Dartt &
  3. Allergan, Inc., Irvine, California, USA
    Michael E. Stern
  4. Tokyo Dental College, Chiba, Japan
    Kazuo Tsubota
  5. Ichikawa General Hospital, Chiba, Japan
    Kazuo Tsubota
  6. University of New Orleans, New Orleans, Louisiana, USA
    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Park, K.I., Lachyankar, M., Nissim, S., Snyder, E.Y. (2002). Neural Stem Cells for Cns Repair: State of the Art and Future Directions. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8\_188

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