Emerging role of polymerase-1 and transcript release factor (PTRF/ Cavin-1) in health and disease (original) (raw)
References
Aboulaich N, Vainonen JP, Stralfors P, Vener AV (2004) Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. Biochem J 383:237–248. doi:10.1042/bj20040647 ArticleCASPubMed CentralPubMed Google Scholar
Aboulaich N, Ortegren U, Vener AV, Stralfors P (2006) Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. Biochem Biophys Res Commun 350:657–661. doi:10.1016/j.bbrc.2006.09.094 ArticleCASPubMed Google Scholar
Aboulaich N, Chui PC, Asara JM, Flier JS, Maratos-Flier E (2011) Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes 60:757–765. doi:10.2337/db10-0744 ArticleCASPubMed CentralPubMed Google Scholar
Aung CS, Hill MM, Bastiani M, Parton RG, Parat MO (2011) PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: role of matrix metalloprotease 9. Eur J Cell Biol 90:136–142. doi:10.1016/j.ejcb.2010.06.004 ArticleCASPubMed Google Scholar
Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA 3rd, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK (2012) Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet 5:336–343. doi:10.1161/circgenetics.111.961888 ArticleCASPubMed CentralPubMed Google Scholar
Badesch DB, Champion HC, Sanchez MA, Hoeper MM, Loyd JE, Manes A, McGoon M, Naeije R, Olschewski H, Oudiz RJ, Torbicki A (2009) Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol 54:S55–S66. doi:10.1016/j.jacc.2009.04.011 ArticlePubMed Google Scholar
Bai L, Deng X, Li J, Wang M, Li Q, An W, Deli A, Cong YS (2011) Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res 21:1088–1101. doi:10.1038/cr.2011.56
Bai L, Deng X, Li Q, Wang M, An W, Deli A, Gao Z, Xie Y, Dai Y, Cong YS (2012) Down-regulation of the cavin family proteins in breast cancer. J Cell Biochem 113:322–328. doi:10.1002/jcb.23358 ArticleCASPubMed Google Scholar
Bitar MS, Abdel-Halim SM, Al-Mulla F (2013) Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Am J Physiol Endocrinol Metab 305:E951–E963. doi:10.1152/ajpendo.00189.2013 ArticleCASPubMed Google Scholar
Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko JK, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, Takeshima H, Ma J (2009) MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol 11:56–64. doi:10.1038/ncb1812 ArticleCASPubMed CentralPubMed Google Scholar
Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP (2010) MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation 121:2565–2574. doi:10.1161/circulationaha.110.954628 ArticleCASPubMed Google Scholar
Cong YS, Fan E, Wang E (2006) Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. Mech Ageing Dev 127:332–343. doi:10.1016/j.mad.2005.12.005 ArticleCASPubMed Google Scholar
Dwianingsih EK, Takeshima Y, Itoh K, Yamauchi Y, Awano H, Malueka RG, Nishida A, Ota M, Yagi M, Matsuo M (2010) A Japanese child with asymptomatic elevation of serum creatine kinase shows PTRF-CAVIN mutation matching with congenital generalized lipodystrophy type 4. Mol Genet Metab 101:233–237. doi:10.1016/j.ymgme.2010.06.016 ArticleCASPubMed Google Scholar
Eren E, Ozkan TB, Cakir ED, Saglam H, Tarim O (2010) Acquired generalized lipodystrophy associated with autoimmune hepatitis and low serum C4 level. J Clin Res Pediatr Endocrinol 2:39–42. doi:10.4274/jcrpe.v2i1.39 ArticlePubMed CentralPubMed Google Scholar
Gamez-Pozo A, Sanchez-Navarro I, Calvo E, Agullo-Ortuno MT, Lopez-Vacas R, Diaz E, Camafeita E, Nistal M, Madero R, Espinosa E, Lopez JA, Fresno Vara JA (2012) PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics. PLoS ONE 7:e33752. doi:10.1371/journal.pone.0033752 ArticleCASPubMed CentralPubMed Google Scholar
Gould ML, Williams G, Nicholson HD (2010) Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression. Prostate 70:1609–1621. doi:10.1002/pros.21195 ArticleCASPubMed Google Scholar
Grummt I, Rosenbauer H, Niedermeyer I, Maier U, Ohrlein A (1986) A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination. Cell 45:837–846 ArticleCASPubMed Google Scholar
Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE (2008) Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci U S A 105:14112–14117. doi:10.1073/pnas.0806158105 ArticleCASPubMed CentralPubMed Google Scholar
Hayashi YK, Matsuda C, Ogawa M, Goto K, Tominaga K, Mitsuhashi S, Park YE, Nonaka I, Hino-Fukuyo N, Haginoya K, Sugano H, Nishino I (2009) Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J Clin Invest 119:2623–2633. doi:10.1172/jci38660 ArticleCASPubMed CentralPubMed Google Scholar
Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614–636 ArticleCASPubMed Google Scholar
Hermann M, Flammer A, Luscher TF (2006) Nitric oxide in hypertension. J Clin Hypertens (Greenwich Conn) 8:17–29 ArticleCAS Google Scholar
Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG (2008) PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 132:113–124. doi:10.1016/j.cell.2007.11.042 ArticleCASPubMed CentralPubMed Google Scholar
Hill MM, Daud NH, Aung CS, Loo D, Martin S, Murphy S, Black DM, Barry R, Simpson F, Liu L, Pilch PF, Hancock JF, Parat MO, Parton RG (2012) Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. PLoS ONE 7:e43041. doi:10.1371/journal.pone.0043041 ArticleCASPubMed CentralPubMed Google Scholar
Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT (2007) Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood 109:3088–3098. doi:10.1182/blood-2006-08-039438 ArticleCASPubMed CentralPubMed Google Scholar
Inder KL, Zheng YZ, Davis MJ, Moon H, Loo D, Nguyen H, Clements JA, Parton RG, Foster LJ, Hill MM (2012) Expression of PTRF in PC-3 Cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways. Mol Cell Proteomics 11(M111):012245. doi:10.1074/mcp.M111.012245 PubMed Google Scholar
Jansa P, Grummt I (1999) Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse. Mol Gen Genet 262:508–514 ArticleCASPubMed Google Scholar
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998) Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J 17:2855–2864. doi:10.1093/emboj/17.10.2855 ArticleCASPubMed CentralPubMed Google Scholar
Jansa P, Burek C, Sander EE, Grummt I (2001) The transcript release factor PTRF augments ribosomal gene transcription by facilitating reinitiation of RNA polymerase I. Nucleic Acids Res 29:423–429 ArticleCASPubMed CentralPubMed Google Scholar
Karbalaei MS, Rippe C, Albinsson S, Ekman M, Mansten A, Uvelius B, Sward K (2012) Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice. Eur J Pharmacol 689:179–185. doi:10.1016/j.ejphar.2012.05.023 ArticleCASPubMed Google Scholar
Liu L, Pilch PF (2008) A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J Biol Chem 283:4314–4322. doi:10.1074/jbc.M707890200 ArticleCASPubMed Google Scholar
Liu L, Brown D, McKee M, Lebrasseur NK, Yang D, Albrecht KH, Ravid K, Pilch PF (2008) Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab 8:310–317. doi:10.1016/j.cmet.2008.07.008 ArticlePubMed CentralPubMed Google Scholar
Liu X, Fassett J, Wei Y, Chen Y (2013) Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evid Based Complement Alternat Med 2013:619207. doi:10.1155/2013/619207
Machado RD, Eickelberg O, Elliott CG, Geraci MW, Hanaoka M, Loyd JE, Newman JH, Phillips JA 3rd, Soubrier F, Trembath RC, Chung WK (2009) Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol 54:S32–S42. doi:10.1016/j.jacc.2009.04.015 ArticleCASPubMed CentralPubMed Google Scholar
Maniatis NA, Shinin V, Schraufnagel DE, Okada S, Vogel SM, Malik AB, Minshall RD (2008) Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1−/− mice. Am J Physiol Lung Cell Mol Physiol 294:L865–L873. doi:10.1152/ajplung.00079.2007 ArticleCASPubMed Google Scholar
Murakami N, Hayashi YK, Oto Y, Shiraishi M, Itabashi H, Kudo K, Nishino I, Nonaka I, Nagai T (2013) Congenital generalized lipodystrophy type 4 with muscular dystrophy: clinical and pathological manifestations in early childhood. Neuromuscul Disord 23:441–444. doi:10.1016/j.nmd.2013.02.005 ArticlePubMed Google Scholar
Nassar ZD, Hill MM, Parton RG, Parat MO (2013a) Caveola-forming proteins caveolin-1 and PTRF in prostate cancer. Nat Rev Urol 10:529–536. doi:10.1038/nrurol.2013.168 PubMed Google Scholar
Nassar ZD, Moon H, Duong T, Neo L, Hill MM, Francois M, Parton RG, Parat MO (2013b) PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget 4:1844–1855
Ortegren U, Yin L, Ost A, Karlsson H, Nystrom FH, Stralfors P (2006) Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions. FEBS J 273:3381–3392. doi:10.1111/j.1742-4658.2006.05345.x ArticlePubMed Google Scholar
Ost A, Ortegren U, Gustavsson J, Nystrom FH, Stralfors P (2005) Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes. J Biol Chem 280:5–8. doi:10.1074/jbc.C400429200 ArticlePubMed Google Scholar
Pernow J, Jung C (2013) Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Cardiovasc Res 98:334–343. doi:10.1093/cvr/cvt036 ArticleCASPubMed Google Scholar
Pilch PF (2008) The mass action hypothesis: formation of Glut4 storage vesicles, a tissue-specific, regulated exocytic compartment. Acta Physiol (Oxford, England) 192:89–101. doi:10.1111/j.1748-1716.2007.01788.x ArticleCAS Google Scholar
Rajab A, Straub V, McCann LJ, Seelow D, Varon R, Barresi R, Schulze A, Lucke B, Lutzkendorf S, Karbasiyan M, Bachmann S, Spuler S, Schuelke M (2010) Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet 6:e1000874. doi:10.1371/journal.pgen.1000874 ArticlePubMed CentralPubMed Google Scholar
Shastry S, Delgado MR, Dirik E, Turkmen M, Agarwal AK, Garg A (2010) Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations. Am J Med Genet A 152A:2245–2253. doi:10.1002/ajmg.a.33578 ArticleCASPubMed CentralPubMed Google Scholar
Sward K, Sadegh MK, Mori M, Erjefalt JS, Rippe C (2013) Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF. Physiol Rep 1:e00008. doi:10.1002/phy2.8 ArticlePubMed CentralPubMed Google Scholar
Verma P, Ostermeyer-Fay AG, Brown DA (2010) Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1. Mol Biol Cell 21:2226–2240. doi:10.1091/mbc.E09-05-0417 ArticleCASPubMed CentralPubMed Google Scholar
Vinten J, Johnsen AH, Roepstorff P, Harpoth J, Tranum-Jensen J (2005) Identification of a major protein on the cytosolic face of caveolae. Biochim Biophys Acta 1717:34–40. doi:10.1016/j.bbamem.2005.09.013 ArticleCASPubMed Google Scholar
Wanaski SP, Ng BK, Glaser M (2003) Caveolin scaffolding region and the membrane binding region of SRC form lateral membrane domains. Biochemistry 42:42–56. doi:10.1021/bi012097n ArticleCASPubMed Google Scholar
Wang X, Xie W, Zhang Y, Lin P, Han L, Han P, Wang Y, Chen Z, Ji G, Zheng M, Weisleder N, Xiao RP, Takeshima H, Ma J, Cheng H (2010) Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res 107:76–83. doi:10.1161/circresaha.109.215822 ArticleCASPubMed Google Scholar
Yi JS, Mun DG, Lee H, Park JS, Lee JW, Lee JS, Kim SJ, Cho BR, Lee SW, Ko YG (2013) PTRF/cavin-1 is essential for multidrug resistance in cancer cells. J Proteome Res 12:605–614. doi:10.1021/pr300651m ArticleCASPubMed Google Scholar
Zheng Y, Lee S, Liang X, Wei S, Moon HG, Jin Y (2013) Suppression of PTRF alleviates the polymicrobial sepsis induced by cecal ligation and puncture in mice. J Infect Dis 208:1803–1812. doi:10.1093/infdis/jit364 ArticleCASPubMed Google Scholar
Zhu H, Lin P, De G, Choi KH, Takeshima H, Weisleder N, Ma J (2011) Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. J Biol Chem 286:12820–12824. doi:10.1074/jbc.C111.221440 ArticleCASPubMed CentralPubMed Google Scholar