Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells (original) (raw)

• Rossi R, Basilico F, Rossoni G, Riva A, Morazzoni P, Mauri PL (2009) Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex. J Pharm Biomed Anal 50:224–227. doi:10.1016/j.jpba.2009.04.026
  Article CAS PubMed Google Scholar
• Bruno C, Cuppini R, Sartini S, Cecchini T, Ambrogini P, Bombardelli E (1993) Regeneration of motor nerves in bilobalide-treated rats. Planta Med 59:302–307. doi:10.1055/s-2006-959686
  Article CAS PubMed Google Scholar
• DeFeudis FV (2002) Bilobalide and neuroprotection. Pharmacol Res 46:565–568. doi:10.1016/S1043-6618(02)00233-5
  Article CAS PubMed Google Scholar
• Ahlemeyer B, Krieglstein J (2003) Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci 60:1779–1792. doi:10.1007/s00018-003-3080-1
  Article CAS PubMed Google Scholar
• Ahlemeyer B, Krieglstein J (2003) Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer’s disease. Pharmacopsychiatry 36(Suppl 1):S8–S14. doi:10.1055/s-2003-40454
  CAS PubMed Google Scholar
• Zhou LJ, Song W, Zhu XZ, Chen ZL, Yin ML, Cheng XF (2000) Protective effects of bilobalide on amyloid beta-peptide 25–35-induced PC12 cell cytotoxicity. Acta Pharmacol Sin 21:75–79
  CAS PubMed Google Scholar
• Zhou LJ, Zhu XZ (2000) Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. J Pharmacol Exp Ther 293:982–988
  CAS PubMed Google Scholar
• Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y (2009) Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis. doi:10.3233/JAD-2009-1189
• Xu Y, Cui C, Pang C, Christen Y, Luo Y (2007) Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells. Eur J Neurosci 26:2931–2939. doi:10.1111/j.1460-9568.2007.05905.x
  Article PubMed Google Scholar
• Nuutinen U, Postila V, Mättö M, Eeva J, Ropponen A, Eray M, Riikonen P, Pelkonen J (2006) Inhibition of PI3-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line. Exp Cell Res 312:322–330. doi:10.1016/j.yexcr.2005.10.023
  CAS PubMed Google Scholar
• Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905–2927. doi:10.1101/gad.13.22.2905
  Article CAS PubMed Google Scholar
• Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM (2000) Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34–41. doi:10.1006/excr.2000.4836
  Article CAS PubMed Google Scholar
• O’Gorman DM, Cotter TG (2001) Molecular signals in anti-apoptotic survival pathways. Leukemia 15:21–34. doi:10.1038/sj.leu.2401998
  Article PubMed Google Scholar
• Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and independent mechanisms. Science 286:1358–1362. doi:10.1126/science.286.5443.1358
  Article CAS PubMed Google Scholar
• Shimoke K, Chiba H (2001) Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase 3-like activity using PC12 cells relevance to therapeutical application for Parkinson’s disease. J Neurosci Res 63:402–409. doi:10.1002/1097-4547(20010301)63:5<402:AID-JNR1035>3.0.CO;2-F
  Article CAS PubMed Google Scholar
• Yu XR, Jia GR, Gao GD, Wang SH, Han Y, Cao W (2006) Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta Biochim Biophys Sin 38:241–248. doi:10.1111/j.1745-7270.2006.00152.x
  Article CAS PubMed Google Scholar
• Shi C, Zhao L, Zhu B, Li Q, Yew DT, Yao Z, Xu J (2009) Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells. Chem Biol Interact 180:389–397. doi:10.1016/j.cbi.2009.04.008
  Article CAS PubMed Google Scholar
• Shi C, Zhao L, Zhu B, Li Q, Yew DT, Yao Z, Xu J (2009) Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells. Chem Biol Interact 181:115–123. doi:10.1016/j.cbi.2009.05.010
  Article CAS PubMed Google Scholar
• Du K, Montminy M (1998) CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273:32377–32379. doi:10.1074/jbc.273.49.32377
  Article CAS PubMed Google Scholar
• Aakalu G, Smith WB, Nguyen N, Jiang C, Schuman EM (2001) Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30:489–502. doi:10.1016/S0896-6273(01)00295-1
  Article CAS PubMed Google Scholar
• Kobayashi MS, Han D, Packer L (2000) Antioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicity. Free Radic Res 32:115–124. doi:10.1080/10715760000300121
  Article CAS PubMed Google Scholar
• Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B (2009) Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am J Physiol Heart Circ Physiol 297:H874–H886. doi:10.1152/ajpheart.00311.2009
  Article CAS PubMed Google Scholar
• Jacotot E, Costantini P, Laboureau E, Zamzami N, Susin SA, Kroemer G (1999) Mitochondrial membrane permeabilization during the apoptotic process. Ann N Y Acad Sci 887:18–30. doi:10.1111/j.1749-6632.1999.tb07919.x
  Article CAS PubMed Google Scholar
• Macdonald NJ, Delderfield SM, Zhang W, Taglialatela G (2003) Tumour necrosis factor-alpha vs. growth factor deprivation-promoted cell death: distinct converging pathways. Aging Cell 2:245–256. doi:10.1046/j.1474-9728.2003.00059.x
  Article CAS PubMed Google Scholar
• Shi C, Guo K, Yew DT, Yao Z, Forster EL, Wang H, Xu J (2008) Effects of ageing and Alzheimer’s disease on mitochondrial function of human platelets. Exp Gerontol 43:589–594. doi:10.1016/j.exger.2008.02.004
  Article CAS PubMed Google Scholar
• Shi C, Yao Z, Xu J, Yew DT (2009) Effects of Gingko Extract (EGb761) on oxidative damage under different conditions of serum supply. J Bioenerg Biomembr 41:61–69. doi:10.1007/s10863-009-9197-7
  Article CAS PubMed Google Scholar
• Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545:51–64. doi:10.1016/j.ejphar.2006.06.025
  Article CAS PubMed Google Scholar
• Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P (2002) Inhibition of amyloid-beta aggregation and caspase 3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 99:12197–12202. doi:10.1073/pnas.182425199
  Article CAS PubMed Google Scholar
• Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489–501. doi:10.1038/nrc839
  Article CAS PubMed Google Scholar
• Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase 9 complex initiates an apoptotic protease. Cell 91:479–489. doi:10.1016/S0092-8674(00)80434-1
  Article CAS PubMed Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868. doi:10.1016/S0092-8674(00)80595-4
  Article CAS PubMed Google Scholar
• Nicholson KM, Anderson NG (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14:381–395. doi:10.1016/S0898-6568(01)00271-6
  Article CAS PubMed Google Scholar
• Zhou BP, Hung MC (2002) Novel targets of Akt, p21(Cipl/WAF1), and MDM2. Semin Oncol 29:62–70. doi:10.1053/sonc.2002.34057
  CAS PubMed Google Scholar
• Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303:1010–1014. doi:10.1126/science.1092734
  Article CAS PubMed Google Scholar
• Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M (2002) Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21:1299–1303. doi:10.1038/sj.onc.1205181
  Article CAS PubMed Google Scholar
• Ramljak D, Coticchia CM, Nishanian TG, Saji M, Ringel MD, Conzen SD, Dickson RB (2003) Epidermal growth factor inhibition of c-Myc-mediumted apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Exp Cell Res 287:397–410. doi:10.1016/S0014-4827(03)00135-6
  Article CAS PubMed Google Scholar
• Farrall AJ, Wardlaw JM (2009) Blood-brain barrier: ageing and microvascular disease—systematic review and meta-analysis. Neurobiol Aging 30:337–352. doi:10.1016/j.neurobiolaging.2007.07.015
  Article CAS PubMed Google Scholar
• Popescu BO, Toescu EC, Popescu LM, Bajenaru O, Muresanu DF, Schultzberg M, Bogdanovic N (2009) Blood-brain barrier alterations in ageing and dementia. J Neurol Sci 283:99–106. doi:10.1016/j.jns.2009.02.321
  Article CAS PubMed Google Scholar
• Shi C, Fang L, Yew DT, Yao Z, Xu J (2010) Ginkgo biloba extract EGb761 protects against mitochondrial dysfunction in platelets and hippocampi in ovariectomized rats. Platelets 21:53–59. doi:10.3109/09537100903395180
  Article CAS PubMed Google Scholar