The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model (original) (raw)

• Penn JS, Henry MM, Tolman BL (1994) Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr Res 36:724–731
  Article PubMed CAS Google Scholar
• Patz A, Eastham A, Higginbotham DH, Kleh T (1953) Oxygen studies in retrolental fibroplasia. Am J Ophthalmol 36:1511–1522
  PubMed CAS Google Scholar
• Patz A (1965) The effect of oxygen on immature retinal vessels [Review] [23 refs]. Invest Ophthalmol 4:988–999
  Google Scholar
• Berkowitz BA, Zhang W (2000) Significant reduction of the panretinal oxygenation response after 28% supplemental oxygen recovery in experimental ROP. Invest Ophthalmol Vis Sci 41:1925–1931
  PubMed CAS Google Scholar
• McColm JR, Hartnett ME (2005) Retinopathy of prematurity: current understanding based on clinical trials and animal models. In: Hartnett MEE, Trese MT, Capone A Jr, Steidl SM, Keats BK (eds) Pediatric retinal diseases: medical and surgical approaches. Lippincot Williams & Wilkins, Philadelphia
• Cryotherapy for Retinopathy of Prematurity Cooperative Group (2001) Multicenter trial of cryotherapy for retinopathy of prematurity ophthalmological outcomes at 10 years. Arch Ophthalmol 119:1110–1118
  Google Scholar
• Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694
  Article PubMed CAS Google Scholar
• Flynn JT (1987) Retinopathy of prematurity. Ped Clin N Am 34:1487–1516
  CAS Google Scholar
• Cryotherapy for Retinopathy of Prematurity Cooperative Group (2002) Multicenter trial of cryotherapy for retinopathy of prematurity: natural history ROP: ocular outcome at 5(1/2) years in premature infants with birth weights less than 1251 g. Arch Ophthalmol 120:595–599
  Google Scholar
• Ernest JT, Goldstick TK (1984) Retinal oxygen tension and oxygen reactivity in retinopathy of prematurity in kittens. Invest Ophthalmol Vis Sci 25:1129–1134
  PubMed CAS Google Scholar
• Saito Y, Uppal A, Byfield G, Budd S, Hartnett ME (2008) Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model. Invest Ophthalmol Vis Sci 49:1591–1598
  Article PubMed Google Scholar
• Terry TL (1942) Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens: (1) preliminary report. Am J Ophthalmol 25:203–204
  Google Scholar
• Wang S, Sorenson CM, Sheibani N (2005) Attenuation of retinal vascular development and neovascularization during oxygen-induced ischemic retinopathy in Bcl-2−/− mice. Dev Biol 279:205–219
  Article PubMed CAS Google Scholar
• Shih SC, Ju M, Liu N, Smith LEH (2003) Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest 112:50–57
  PubMed CAS Google Scholar
• Alon T, Hemo I, Itin A, Peer J, Stone J, Keshet E (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1:1024–1028
  Article PubMed CAS Google Scholar
• Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, Grant MB (2007) IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci USA 104:10595–10600
  Article PubMed CAS Google Scholar
• Lofqvist C, Chen J, Connor KM, Smith ACH, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LEH (2007) From the cover: IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci USA 104:10589–10594
  Article PubMed CAS Google Scholar
• Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LEH (2007) Increased dietary intake of [omega]-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 13:868–873
  Article PubMed CAS Google Scholar
• Neu J, Afzal A, Pan H, Gallego E, Calzi SL, Caballero S, Spoerri PE, Shaw LC, Grant MB (2006) The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 47:3151–3155
  Article PubMed Google Scholar
• Penn JS (1992) Oxygen-induced retinopathy in the rat. Vitamins C and E as potential therapies. Invest Ophthalmol Vis Sci 33:1836–1845
  PubMed CAS Google Scholar
• Penn JS, Tolman BL, Bullard LE (1997) Effect of a water-soluble vitamin E analog, Trolox C, on retinal vascular development in an animal model of retinopathy of prematurity. Free Radic Biol Med 22:977–984
  Article PubMed CAS Google Scholar
• Niesman MR, Johnson KA, Penn JS (1997) Therapeutic effect of liposomal superoxide dismutase in an animal model of retinopathy of prematurity. Neurochem Res 22:597–605
  Article PubMed CAS Google Scholar
• Saito Y, Geisen P, Uppal A, Hartnett ME (2007) Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis 13:840–853
  PubMed CAS Google Scholar
• Ashton N, Cook C (1954) Direct observation of the effect of oxygen on developing vessels: preliminary report. Br J Ophthalmol 38:433–440
  Article PubMed CAS Google Scholar
• Michaelson IC (1948) The mode of development of the vascular system of the retina. With some observations on its significance for certain retinal diseases. Trans Ophthal Soc UK 68:137–180
  Google Scholar
• Cunningham S, Fleck BW, Elton RA, Mclntosh N (1995) Transcutaneous oxygen levels in retinopathy of prematurity. Lancet 346:1464–1465
  Article PubMed CAS Google Scholar
• McColm JR, Cunningham S, Wade J, Sedowofia K, Gellen B, Sharma T, McIntosh N, Fleck BW (2004) Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity. Pediatr Res 55:107–113
  Article PubMed CAS Google Scholar
• Saito Y, Omoto T, Cho Y, Hatsukawa Y, Fujimura M, Takeuchi T (1993) The progression of retinopathy of prematurity and fluctuation in blood gas tension. Graefes Arch Clin Exp Ophthalmol 231:151–156
  Article PubMed CAS Google Scholar
• Chow LC, Wright KW, Sola A (2003) Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics 111:339–345
  Article PubMed Google Scholar
• Wedrychowicz A, Dziatkowiak H, Nazim J, Sztefko K (2005) Insulin-like growth factor-1 and its binding proteins, IGFBP-1 and IGFBP-3, in adolescents with type-1 diabetes mellitus and microalbuminuria. Horm Res 63(5):245–299
  Article PubMed CAS Google Scholar
• Tin W, Milligan DWA, Pennefather PM, Hey E (2001) Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonat Ed 84:106–110
  Article Google Scholar
• Werdich XQ, McCollum GW, Rajaratnam VS, Penn JS (2004) Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy. Exp Eye Res 79:623–630
  Article PubMed CAS Google Scholar
• McColm JR, Cunningham S, Yerden R (1999) A computer controlled system to simulate the small, rapid oxygen fluctuations experienced by preterm infants developing retinopathy of prematurity. Scott Med J 44(1):28–29
  Google Scholar
• Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH (1995) Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 92:905–909
  Article PubMed CAS Google Scholar
• Penn JS, Henry MM, Wall PT, Tolman BL (1995) The range of PaO2 variation determines the severity of oxygen induced retinopathy in newborn rats. Invest Ophthalmol Vis Sci 36:2063–2070
  PubMed CAS Google Scholar
• Phelps DL (1988) Reduced severity of oxygen-induced retinopathy in kittens recovered in 28% oxygen. Pediatr Res 24:106–109
  Article PubMed CAS Google Scholar
• Gu X, Samuel S, El shabrawey M, Caldwell RB, Bartoli M, Marcus DM, Brooks SE (2002) Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 43:496–502
  PubMed Google Scholar
• The STOP-ROP Multicenter Study Group (2000) Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes. Pediatrics 105:295–310
  Article Google Scholar
• Wallace DK, Veness-Meehan KA, Miller WC (2007) Incidence of severe retinopathy of prematurity before and after a modest reduction in target oxygen saturation levels. J AAPOS 11:170–174
  Article PubMed Google Scholar
• Vanderveen DK, Mansfield TA, Eichenwald EC (2006) Lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity. J AAPOS 10:445–448
  Article PubMed Google Scholar
• Liu K, Akula JD, Falk C, Hansen RM, Fulton AB (2006) The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci 47:2639–2647
  Article PubMed Google Scholar
• Hartnett ME, Martiniuk DJ, Byfield GE, Geisen P, Zeng G, Bautch VL (2008) Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in rat model of ROP: relevance to plus disease. Invest Ophthalmol Vis Sci 49(7):3107–3114. Epub 2008 Mar 31
  Google Scholar
• McColm JR, Geisen P, Hartnett ME (2004) VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP. Mol Vis 10:512–520
  PubMed CAS Google Scholar
• Werdich XQ, Penn JS (2006) Specific involvement of Src family kinase activation in the pathogenesis of retinal neovascularization. Invest Ophthalmol Vis Sci 47:5047–5056
  Article PubMed Google Scholar
• Aylward SR, Bullitt E (2002) Initialization, noise, singularities, and scale in height ridge traversal for tubular object centerline extraction. IEEE Trans Med Imaging 21:61–75
  Article PubMed Google Scholar
• Chan-Ling T, Gock B, Stone J (1995) The effect of oxygen on vasoformative cell division: evidence that ‘physiological hypoxia’ is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci 36:1201–1214
  PubMed CAS Google Scholar
• Stone J, Itin A, Alon T, Peer J, Gnessin H, Chan-Ling T, Keshet E (1995) Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 15:4738–4747
  PubMed CAS Google Scholar
• Saint-Geniez M, Maldonado AE, D’Amore PA (2006) VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci 47:3135–3142
  Article PubMed Google Scholar
• Maharaj ASR, Saint-Geniez M, Maldonado AE, D’Amore PA (2006) Vascular endothelial growth factor localization in the adult. Am J Pathol 168:639–648
  Article PubMed CAS Google Scholar
• Robinson GS, Aiello LP (1998) Angiogenic factors in diabetic ocular disease: mechanisms of today, therapies for tomorrow. Int Ophthalmol Clin 38:89–102
  PubMed CAS Google Scholar
• Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, Yeo KT (1994) Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 118:445–450
  PubMed CAS Google Scholar
• Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285:245–248
  Article PubMed CAS Google Scholar
• Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, Katai M, Yan L, Suzuma K, West K, Pearlman J, Crabb JW, Aiello LP, Campochiaro PA, Zack DJ (2002) Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci 43:821–829
  PubMed Google Scholar
• Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA (2002) Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 43:2428–2434
  PubMed Google Scholar
• Gao G, Li Y, Gee S, Dudley A, Fant J, Crosson C, Ma J (2002) Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor. A possible mechanism for the anti-angiogenesis activity of plasminogen kringle 5. J Biol Chem 277:9492–9497
  Article PubMed CAS Google Scholar
• Shima DT, Kuroki M, Deutsch U, Ng YS, Adamis AP, D’Amore PA (1996) The mouse gene for vascular endothelial growth factor. J Biol Chem 271:3877–3883
  Article PubMed CAS Google Scholar
• Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA (1991) The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266:11947–11954
  PubMed CAS Google Scholar
• Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D’Amore PA, Shima DT, Adamis AP (2003) VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 198:483–489
  Article PubMed CAS Google Scholar
• Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP (2004) VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest Ophthalmol Vis Sci 45:368–374
  Article PubMed Google Scholar
• Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML (2005) Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169:681–691
  Article PubMed CAS Google Scholar
• Stalmans I, Ng YS, Rohan R, Fruttiger M, Bouche A, Yuce A, Fujisawa H, Hermans B, Shani M, Jansen S, Hicklin D, Anderson DJ, Gardiner TA, Hammes HP, Moons L, Dewerchin M, Collen D, Carmeliet P, D’Amore PA (2002) Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest 109:327–336
  PubMed CAS Google Scholar
• Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard J-C, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D’Amore PA, Shima DT (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med 5:495–501
  Article PubMed CAS Google Scholar
• Ng YS, Rohan R, Sunday ME, Demello DE, D’Amore PA (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220:112–121
  Article PubMed CAS Google Scholar
• Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, Fujisawa H, Betsholtz C, Shima DT (2002) Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 16:2684–2698
  Article PubMed CAS Google Scholar
• Hutchings H, Ortega N, Plouet J (2003) Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation. FASEB J 17:1520–1522
  PubMed CAS Google Scholar
• Pierce E, Foley E, Lois EH (1996) Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 114:1219–1228
  PubMed CAS Google Scholar
• Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161:1163–1177
  Article PubMed CAS Google Scholar
• Geisen P, Peterson LJ, Martiniuk D, Uppal A, Saito Y, Hartnett ME (2008) Neutralizing antibody to VEGF reduces intravitreous neovascularization and does not interfere with vascularization of avascular retina in an ROP model. Mol Vis 14:345–357
  PubMed CAS Google Scholar
• Hughes S, Gardiner T, Baxter L, Chan-Ling T (2007) Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: implications for plus disease. Invest Ophthalmol Vis Sci 48:1368–1379
  Article PubMed Google Scholar
• Holland D, Saunders R, Kagemann L, Bluestein E, Hutchinson A, Corson D, Harris A (1999) Color Doppler imaging of the central retinal artery in premature infants undergoing examination for retinopathy of prematurity. J AAPOS 3:194–198
  Article PubMed CAS Google Scholar
• Niwald A, Gralek M (2006) Evaluation of blood flow in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity. Klin Oczna 108:32–35
  PubMed Google Scholar
• Brooks SE, Gu X, Samuel S, Marcus DM, Bartoli M, Huang PL, Caldwell RB (2001) Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Invest Ophthalmol Vis Sci 42:222–228
  PubMed CAS Google Scholar
• Zeng G, Taylor SM, McColm JR, Kappas NC, Kearney JB, Williams LH, Hartnett ME, Bautch VL (2007) Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Blood 109:1345–1352
  Article PubMed CAS Google Scholar
• Katz ML, Robison WG Jr (1988) Autoxidative damage to the retina: potential role in retinopathy of prematurity. Birth Defects 24:237–248
  PubMed CAS Google Scholar
• Penn JS (1990) Oxygen-induced retinopathy in the rat: possible contribution of peroxidation reactions. Doc Ophthalmol 74:179–186
  Article PubMed CAS Google Scholar
• Phelps DL, Rosenbaum AL (1979) Observations of vitamin E in experimental oxygen-induced retinopathy. Ophthalmology 86:1741–1748
  PubMed CAS Google Scholar
• Penn JS, Tolman BL, Lowery LA (1993) Variable oxygen exposure causes preretinal neovascularisation in the newborn rat. Invest Ophthalmol Vis Sci 34:576–585
  PubMed CAS Google Scholar
• Ushio-Fukai M (2006) Redox signaling in angiogenesis: role of NADPH oxidase. Cardiovasc Res 71:226–235
  Article PubMed CAS Google Scholar
• Jay Forman H, Torres M (2001) Redox signaling in macrophages. Mol Aspects Med 22:189–216
  Article CAS Google Scholar
• Al Shabrawey M, Bartoli M, El Remessy AB, Platt DH, Matragoon S, Behzadian MA, Caldwell RW, Caldwell RB (2005) Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy. Am J Pathol 167:599–607
  PubMed CAS Google Scholar
• Raju TNK, Langenberg P, Bhutani V, Quinn GE (1997) Vitamin E prophylaxis to reduce retinopathy of prematurity: a reappraisal of published trials. J Pediatr 131:844–850
  Article PubMed CAS Google Scholar
• Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV (2006) Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol 168:1722–1736
  Article PubMed CAS Google Scholar
• Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M (2007) Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci USA 104:967–972
  Article PubMed CAS Google Scholar
• Jo N, Mailhos C, Ju M, Cheung E, Bradley J, Nishijima K, Robinson GS, Adamis AP, Shima DT (2006) Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 168:2036–2053
  Article PubMed CAS Google Scholar
• Sears JE, Pietz J, Sonnie C, Dolcini D, Hoppe G (2009) A change in oxygen supplementation can decrease the incidence of retinopathy of prematurity. Ophthalmology 116:513–518
  Article PubMed Google Scholar
• Byfield GE, Budd S, Hartnett ME (2009) Supplemental oxygen can cause intravitreous neovascularization through JAK/STAT pathways in a model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. Epub (Mar 5), PMID: 19264880
• Ushio-Fukai M, Alexander RW (2004) Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase. Mol Cell Biochem V264:85–97
  Article Google Scholar
• Ushio-Fukai M (2007) VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 9:731–739
  Article PubMed CAS Google Scholar
• Liu T, Castro S, Brasier AR, Jamaluddin M, Garofalo RP, Casola A (2004) Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. J Biol Chem 279:2461–2469
  Article PubMed CAS Google Scholar
• Lee YJ, Heo JS, Suh HN, Lee MY, Han HJ (2007) Interleukin-6 stimulates {alpha}-MG uptake in renal proximal tubule cells: involvement of STAT3, PI3K/Akt, MAPKs, and NF-{kappa}B. Am J Physiol Renal Physiol 293:F1036–F1046
  Article PubMed CAS Google Scholar
• Banes AK, Shaw S, Jenkins JA, Redd H, Amiri F, Pollock DM, Marrero MB (2004) Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol 286:F653–F659
  Article PubMed CAS Google Scholar
• Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LEH (1996) Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 93:4851–4856
  Article PubMed CAS Google Scholar
• Akula JD, Hansen RM, Martinez-Perez ME, Fulton AB (2007) Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurity. Invest Ophthalmol Vis Sci 48:4351–4359
  Article PubMed Google Scholar
• Berkowitz BA, Roberts R, Penn JS, Gradianu M (2007) High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 48:4733–4740
  Article PubMed Google Scholar
• Cringle SJ, Yu PK, Su EN, Yu DY (2006) Oxygen distribution and consumption in the developing rat retina. Invest Ophthalmol Vis Sci 47:4072–4076
  Article PubMed Google Scholar