Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation (original) (raw)

• Kennedy BK, Steffen KK, Kaeberlein M. Ruminations on dietary restriction and aging. Cell Mol Life Sci. 2007;64:1323–8.
  Article PubMed CAS Google Scholar
• Omodei D, Fontana L. Calorie restriction and prevention of age-associated chronic disease. FEBS Lett. 2011;585:1537–42.
  Article PubMed CAS Google Scholar
• Grifantini K. Understanding pathways of calorie restriction: a way to prevent cancer? J Natl Cancer Inst. 2008;100:619–21.
  Article PubMed Google Scholar
• Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010;31:89–98.
  Article PubMed CAS Google Scholar
• Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005;12 Suppl 2:1542–52.
  Article PubMed CAS Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069–75.
  Article PubMed CAS Google Scholar
• Gump JM, Thorburn A. Autophagy and apoptosis: what is the connection? Trends Cell Biol. 2011;21:387–92.
  Article PubMed CAS Google Scholar
• Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis. 2008;13:1–9.
  Article PubMed CAS Google Scholar
• Warburg O. On the origin of cancer cells. Science. 1956;123:309–14.
  Article PubMed CAS Google Scholar
• Levy JM, Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther. 2011;131:130–41.
  Article PubMed CAS Google Scholar
• Maycotte P, Thorburn A. Autophagy and cancer therapy. Cancer Biol Ther. 2011;11:127–37.
  Article PubMed CAS Google Scholar
• Fan C, Wang W, Zhao B, Zhang S, Miao J. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg Med Chem. 2006;14:3218–22.
  Article PubMed CAS Google Scholar
• Jiang PD, Zhao YL, Deng XQ, Mao YQ, Shi W, Tang QQ, et al. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed Pharmacother. 2010;64:609–14.
  Article PubMed CAS Google Scholar
• Munshi A. Chloroquine in glioblastoma–new horizons for an old drug. Cancer. 2009;115:2380–3.
  Article PubMed CAS Google Scholar
• Rahim R, Strobl JS. Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. Anticancer Drugs. 2009;20:736–45.
  Article PubMed CAS Google Scholar
• Solomon VR, Hu C, Lee H. Design and synthesis of chloroquine analogs with anti-breast cancer property. Eur J Med Chem. 2010;45:3916–23.
  Article PubMed CAS Google Scholar
• Zheng Y, Zhao YL, Deng X, Yang S, Mao Y, Li Z, et al. Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis. Cancer Invest. 2009;27:286–92.
  Article PubMed CAS Google Scholar
• Hu C, Solomon VR, Ulibarri G, Lee H. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg Med Chem. 2008;16:7888–93.
  Article PubMed CAS Google Scholar
• Solomon VR, Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol. 2009;625:220–33.
  Article PubMed CAS Google Scholar
• Poole B, Ohkuma S. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol. 1981;90:665–9.
  Article PubMed CAS Google Scholar
• Glaumann H, Ahlberg J. Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity–formation of crinosomes. Exp Mol Pathol. 1987;47:346–62.
  Article PubMed CAS Google Scholar
• Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005;120:237–48.
  Article PubMed CAS Google Scholar
• Carew JS, Medina EC, Esquivel 2nd JA, Mahalingam D, Swords R, Kelly K, et al. Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. J Cell Mol Med. 2010;14:2448–59.
  Article PubMed CAS Google Scholar
• Kaludjerovic GN, Miljkovic D, Momcilovic M, Djinovic VM, Mostarica Stojkovic M, Sabo TJ, et al. Novel platinum(IV) complexes induce rapid tumor cell death in vitro. Int J Cancer. 2005;116:479–86.
  Article PubMed CAS Google Scholar
• Harhaji L, Isakovic A, Vucicevic L, Janjetovic K, Misirkic M, Markovic Z, et al. Modulation of tumor necrosis factor-mediated cell death by fullerenes. Pharm Res. 2008;25:1365–76.
  Article PubMed CAS Google Scholar
• Bastien-Dionne PO, Valenti L, Kon N, Gu W, Buteau J. Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion. Diabetes. 2011;60:3217–22.
  Google Scholar
• Kaushik S, Rodriguez-Navarro JA, Arias E, Kiffin R, Sahu S, Schwartz GJ, et al. Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab. 2011;14:173–83.
  Article PubMed CAS Google Scholar
• Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005;171:603–14.
  Article PubMed Google Scholar
• Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem. 1997;243:240–6.
  Article PubMed CAS Google Scholar
• Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy. 2008;4:849–950.
  PubMed CAS Google Scholar
• Rogers SW, Rechsteiner M. Degradation of structurally characterized proteins injected into HeLa cells. Effects of intracellular location and the involvement of lysosomes. J Biol Chem. 1988;263:19843–9.
  PubMed CAS Google Scholar
• van Es HH, Renkema H, Aerts H, Schurr E. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene. Mol Biochem Parasitol. 1994;68:209–19.
  Article PubMed Google Scholar
• Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept. J Physiol. 2006;574:7–15.
  Article PubMed CAS Google Scholar
• Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol. 2005;25:1025–40.
  Article PubMed CAS Google Scholar
• Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy. 2012;8:200–12.
  Article PubMed CAS Google Scholar
• Yoon YH, Cho KS, Hwang JJ, Lee SJ, Choi JA, Koh JY. Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells. Invest Ophthalmol Vis Sci. 2010;51:6030–7.
  Article PubMed Google Scholar
• Michihara A, Toda K, Kubo T, Fujiwara Y, Akasaki K, Tsuji H. Disruptive effect of chloroquine on lysosomes in cultured rat hepatocytes. Biol Pharm Bull. 2005;28:947–51.
  Article PubMed CAS Google Scholar
• Jiang PD, Zhao YL, Shi W, Deng XQ, Xie G, Mao YQ, et al. Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37. Cell Physiol Biochem. 2008;22:431–40.
  Article PubMed CAS Google Scholar
• Loeffler M, Kroemer G. The mitochondrion in cell death control: certainties and incognita. Exp Cell Res. 2000;256:19–26.
  Article PubMed CAS Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta. 2006;1757:509–17.
  Article PubMed CAS Google Scholar
• Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003;304:463–70.
  Article PubMed CAS Google Scholar
• Ono K, Wang X, Han J. Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency. Mol Cell Biol. 2001;21:8276–88.
  Article PubMed CAS Google Scholar
• Ershler WB, Berman E, Moore AL. Slower B16 melanoma growth but greater pulmonary colonization in calorie-restricted mice. J Natl Cancer Inst. 1986;76:81–5.
  PubMed CAS Google Scholar
• Inoue S, Hasegawa K, Ito S, Wakamatsu K, Fujita K. Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin. Pigment Cell Res. 1993;6:354–8.
  Article PubMed CAS Google Scholar
• Vogler C, Rosenberg HS, Williams JC, Butler I. Electron microscopy in the diagnosis of lysosomal storage diseases. Am J Med Genet Suppl. 1987;3:243–55.
  Article PubMed CAS Google Scholar
• Lin CL, Huang HC, Lin JK. Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J Lipid Res. 2007;48:2334–43.
  Article PubMed CAS Google Scholar
• Jarzyna R, Lenarcik E, Bryla J. Chloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbit. Pharmacol Res. 1997;35:79–84.
  Article PubMed CAS Google Scholar
• Mastorodemos V, Zaganas I, Spanaki C, Bessa M, Plaitakis A. Molecular basis of human glutamate dehydrogenase regulation under changing energy demands. J Neurosci Res. 2005;79:65–73.
  Article PubMed CAS Google Scholar
• Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 2011;19:613–28.
  Article PubMed CAS Google Scholar