Pten is essential for embryonic development and tumour suppression (original) (raw)
Li, J. et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science275, 1943–1947 (1997). ArticleCAS Google Scholar
Steck, P.A. et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nature Genet.15, 356–362 ( 1997). ArticleCAS Google Scholar
Guldberg, P. et al. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res.57, 3660–3663 (1997). CASPubMed Google Scholar
Risinger, J.I., Hayes, A.K., Berchuck, A. & Barrett, J.C. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res.57, 4736–4738 (1997). CASPubMed Google Scholar
Liaw, D. et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nature Genet.16 , 64–67 (1997). ArticleCAS Google Scholar
Marsh, D.J. et al. Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosom. Cancer21, 61–69 (1998).
Nelen, M.R. et al. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease . Hum. Mol. Genet.6, 1383– 1387 (1997). ArticleCAS Google Scholar
Bannayan, G.A. Lipomatosis, angiomatosis, and macrencephalia. A previously undescribed congenital syndrome . Arch. Pathol.92, 1–5 (1971). CASPubMed Google Scholar
Zonana, J., Rimoin, D.L. & Davis, D.C. Macrocephaly with multiple lipomas and hemangiomas. J. Paediatr.89, 600–603 ( 1976). ArticleCAS Google Scholar
Eng, C. et al. Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J. Med. Genet.31, 458– 461 (1994). ArticleCAS Google Scholar
Myers, M.P. & Tonks, N.K. PTEN: sometimes taking it off can be better than putting it on. Am. J. Hum. Genet.61, 1234–1238 (1997). ArticleCAS Google Scholar
Barford, D., Jia, Z. & Tonks, N.K. Protein tyrosine phosphatases take off. Nature Struct. Biol.2, 1043–1053 (1995). ArticleCAS Google Scholar
Furnari, F.B., Lin, H., Huang, H.S. & Cavenee, W.K. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl Acad. Sci. USA94, 12479 –12484 (1997). ArticleCAS Google Scholar
Akiyama, S.K., Olden, K. & Yamada, K.M. Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev.14, 173–189 ( 1995). ArticleCAS Google Scholar
Tamura, M. et al. Inhibition of cell migration, spreading and focal adhesions by tumour suppressor PTEN. Science280, 1614– 1617 (1998). ArticleCAS Google Scholar
Thomas, K.R. & Capecchi, M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell51, 503–512 (1987). ArticleCAS Google Scholar
Tybulewicz, V.L.J., Crawford, C.E., Jackson, P.K., Bronson, R.T. & Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell65, 1153–1163 ( 1991). ArticleCAS Google Scholar
Padberg, G.W., Schot, J.D., Vielvoye, G.J., Bots, G.T. & de Beer, F.C. Lhermitte-Duclos disease and Cowden disease: a single phakomatosis. Ann. Neurol. 29, 517– 523 (1991). ArticleCAS Google Scholar
Gerlach, C., Golding, M., Larue, L., Alison, M.R. & Gerdes, J. Ki-67 immunoexpression is a robust marker of proliferative cells in the rat. Lab. Invest.77, 697– 698 (1997). CASPubMed Google Scholar
Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W. & Kemler, R. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol.87, 27–45 (1985). CASPubMed Google Scholar
Robertson, E.J., Teratocarcinomas and embryonic stem cells: a practical approach. (IRL, Oxford, U.K.,1987). Google Scholar
Keller, G., Kennedy, M., Papayannopoulou, T. & Wiles, M.V. Hematopoietic commitment during embryonic stem cell differentiation in culture . Mol. Cell. Biol.13, 473– 486 (1993). ArticleCAS Google Scholar
Coucouvanis, E. & Martin, G.R. Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell83, 279–287 ( 1995). ArticleCAS Google Scholar
Rosti, V. et al. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion. J. Clin. Invest.100, 1028–1036 (1997). ArticleCAS Google Scholar
Elefanty, A.G., Robb, L., Birner, R. & Begley, C.G. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells. Blood90, 1435– 1447 (1997). CASPubMed Google Scholar
Winnier, G., Blessing, M., Labosky, P.A. & Hogan, B.L. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev.9, 2105–2116 (1995). ArticleCAS Google Scholar
Collignon, J. et al. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development122, 509– 520 (1996). CASPubMed Google Scholar
Roach, S., Schmid, W. & Pera, M.F. Hepatocytic transcription factor expression in human embryonal carcinoma and yolk sac carcinoma cell lines: expression of HNF-3 alpha in models of early endodermal cell differentiation. Exp. Cell. Res.215 , 189–198 (1994). ArticleCAS Google Scholar
Chen, W.S. et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev.8, 2466–2477 (1994). ArticleCAS Google Scholar
Sirard, C. et al. The tumour suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev.12, 107–119 (1998). ArticleCAS Google Scholar
Edelhoff, S. et al. Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene9, 665–668 (1994). CASPubMed Google Scholar
Shapiro, D.N. et al. Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25 . Genomics23, 282–285 (1994). ArticleCAS Google Scholar
Wechsler, D.S. et al. Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. Genomics21, 669– 672 (1994). ArticleCAS Google Scholar
Marsh, D.J. et al. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum. Mol. Genet.7, 507–515 (1998). ArticleCAS Google Scholar
Kinzler, K.W. & Vogelstein, B. Landscaping the cancer terrain . Science280, 1036–1037 (1998). ArticleCAS Google Scholar
Whang, Y.E. et al. Inactivation of the tumour suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl Acad. Sci. USA95, 5246–5250 (1998). ArticleCAS Google Scholar
Schreiber-Agus, N. et al. Role of Mxi1 in aging organ systems and the regulation of normal and neoplastic growth. Nature393, 483– 487 (1998). ArticleCAS Google Scholar
Eagle, L.R. et al. Mutation of the MXI1 gene in prostate cancer. Nature Genet.9, 249–255 ( 1995). ArticleCAS Google Scholar
Howe, J.R. et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science280, 1086–1088 ( 1998). ArticleCAS Google Scholar
Takaku, K. et al. Intestinal tumour igenesis in compound mutant mice of both Dpc4 ( Smad4) and Apc gene. Cell92, 645–656 (1998). ArticleCAS Google Scholar
Serrano, M. et al. Role of the INK4a locus in tumour suppression and cell mortality. Cell85, 27–37 ( 1996). ArticleCAS Google Scholar
Suzuki, H. et al. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res.58, 204–209 (1998). CASPubMed Google Scholar
Wiles, M.V. Embryonic stem cell differentiation in vitro. Methods Enzymol.225 , 900–918 (1993). ArticleCAS Google Scholar