A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection (original) (raw)
- Letter
- Published: 20 March 1997
- Yukiko Kurihara3,
- Motohiro Takeya4,
- Nobuo Kamada1,
- Motoyukl Kataoka2,
- Kouichi Jishage1,
- Otoya Ueda1,
- Hisashl Sakaguchi4,
- Takayuki Higashi5,
- Tsukasa Suzuki1,
- Yoshiaki Takashima1,
- Yoshiki Kawabe1,15,
- Osamu Cynshi1,
- Youichiro Wada3,
- Makoto Honda3,
- Hiroki Kurihara3,
- Hiroyuki Aburatani3,
- Takefumi Doi6,
- Akiyo Matsumoto7,
- Sadahiro Azuma8,
- Tetsuo Noda9,
- Yutaka Toyoda10,
- Hiroshige Itakura7,
- Yoshio Yazaki3,
- Seikoh Horiuchi5,
- Kiyoshi Takahashi4,
- J. Kar Kruijt11,
- Theo J. C. van Berkel11,
- Urs P. Steinbrecher12,
- Shun Ishibashi3,
- Nobuyo Maeda13,
- Siamon Gordon14 &
- …
- Tatsuhiko Kodama15
Nature volume 386, pages 292–296 (1997)Cite this article
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Abstract
Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL)1–6. MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens7, and also mediates cation-independent macrophage adhesion _in vitro_8. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.
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Authors and Affiliations
- Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Shizuoka, 412, Japan
Hiroshi Suzuki, Nobuo Kamada, Kouichi Jishage, Otoya Ueda, Tsukasa Suzuki, Yoshiaki Takashima, Yoshiki Kawabe & Osamu Cynshi - CSK Research Park Inc., 1-135 Komakado, Shizuoka, 412, Japan
Motoyukl Kataoka - Third Department of Internal Medicine, University of Tokyo, Tokyo, 113, Japan
Yukiko Kurihara, Youichiro Wada, Makoto Honda, Hiroki Kurihara, Hiroyuki Aburatani, Yoshio Yazaki & Shun Ishibashi - Department of Pathology, Kumamoto University School of Medicine, Kumamoto, 860, Japan
Motohiro Takeya, Hisashl Sakaguchi & Kiyoshi Takahashi - Department of Biochemistry, Kumamoto University School of Medicine, Kumamoto, 860, Japan
Takayuki Higashi & Seikoh Horiuchi - Faculty of Pharmaceutical Science, Osaka University, Osaka, 565, Japan
Takefumi Doi - National Institute of Health and Nutrition, Tokyo, 162, Japan
Akiyo Matsumoto & Hiroshige Itakura - Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan
Sadahiro Azuma - Cancer Institute, Tokyo, 170, Japan
Tetsuo Noda - The Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080, Japan
Yutaka Toyoda - Division of Biopharmaceutics, Leiden University, Leiden, 2300 RA, The Netherlands
J. Kar Kruijt & Theo J. C. van Berkel - Department of Medicine, University of British Columbia, Vancouver, V5Z4E3, Canada
Urs P. Steinbrecher - Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27599-7525, USA
Nobuyo Maeda - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
Siamon Gordon - Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, 153, Japan
Hiroshi Suzuki, Yoshiki Kawabe & Tatsuhiko Kodama
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Suzuki, H., Kurihara, Y., Takeya, M. et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.Nature 386, 292–296 (1997). https://doi.org/10.1038/386292a0
- Received: 12 November 1996
- Accepted: 28 January 1997
- Issue Date: 20 March 1997
- DOI: https://doi.org/10.1038/386292a0
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