A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection (original) (raw)

Nature volume 386, pages 292–296 (1997)Cite this article

Abstract

Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL)1–6. MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens7, and also mediates cation-independent macrophage adhesion _in vitro_8. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

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Authors and Affiliations

  1. Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Shizuoka, 412, Japan
    Hiroshi Suzuki, Nobuo Kamada, Kouichi Jishage, Otoya Ueda, Tsukasa Suzuki, Yoshiaki Takashima, Yoshiki Kawabe & Osamu Cynshi
  2. CSK Research Park Inc., 1-135 Komakado, Shizuoka, 412, Japan
    Motoyukl Kataoka
  3. Third Department of Internal Medicine, University of Tokyo, Tokyo, 113, Japan
    Yukiko Kurihara, Youichiro Wada, Makoto Honda, Hiroki Kurihara, Hiroyuki Aburatani, Yoshio Yazaki & Shun Ishibashi
  4. Department of Pathology, Kumamoto University School of Medicine, Kumamoto, 860, Japan
    Motohiro Takeya, Hisashl Sakaguchi & Kiyoshi Takahashi
  5. Department of Biochemistry, Kumamoto University School of Medicine, Kumamoto, 860, Japan
    Takayuki Higashi & Seikoh Horiuchi
  6. Faculty of Pharmaceutical Science, Osaka University, Osaka, 565, Japan
    Takefumi Doi
  7. National Institute of Health and Nutrition, Tokyo, 162, Japan
    Akiyo Matsumoto & Hiroshige Itakura
  8. Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan
    Sadahiro Azuma
  9. Cancer Institute, Tokyo, 170, Japan
    Tetsuo Noda
  10. The Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080, Japan
    Yutaka Toyoda
  11. Division of Biopharmaceutics, Leiden University, Leiden, 2300 RA, The Netherlands
    J. Kar Kruijt & Theo J. C. van Berkel
  12. Department of Medicine, University of British Columbia, Vancouver, V5Z4E3, Canada
    Urs P. Steinbrecher
  13. Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27599-7525, USA
    Nobuyo Maeda
  14. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Siamon Gordon
  15. Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, 153, Japan
    Hiroshi Suzuki, Yoshiki Kawabe & Tatsuhiko Kodama

Authors

  1. Hiroshi Suzuki
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  2. Yukiko Kurihara
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  3. Motohiro Takeya
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  4. Nobuo Kamada
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  5. Motoyukl Kataoka
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  6. Kouichi Jishage
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  7. Otoya Ueda
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  8. Hisashl Sakaguchi
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  9. Takayuki Higashi
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  10. Tsukasa Suzuki
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  11. Yoshiaki Takashima
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  12. Yoshiki Kawabe
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  13. Osamu Cynshi
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  14. Youichiro Wada
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  15. Makoto Honda
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  16. Hiroki Kurihara
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  17. Hiroyuki Aburatani
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  18. Takefumi Doi
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  19. Akiyo Matsumoto
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  20. Sadahiro Azuma
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  21. Tetsuo Noda
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  22. Yutaka Toyoda
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  23. Hiroshige Itakura
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  24. Yoshio Yazaki
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  25. Seikoh Horiuchi
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  26. Kiyoshi Takahashi
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  27. J. Kar Kruijt
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  28. Theo J. C. van Berkel
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  29. Urs P. Steinbrecher
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  30. Shun Ishibashi
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  31. Nobuyo Maeda
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  32. Siamon Gordon
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  33. Tatsuhiko Kodama
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Suzuki, H., Kurihara, Y., Takeya, M. et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.Nature 386, 292–296 (1997). https://doi.org/10.1038/386292a0

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