Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection (original) (raw)

References

  1. Reiner, S.L. & Locksley, R.M. The regulation of immunity to Leishmania major. Annu. Rev. Immuol. 13, 151–177 (1995).
    Article CAS Google Scholar
  2. Heinzel, F.P., Schoenhaut, D.S., Rerko, R.M., Rosser, L.E. & Gately, M.K. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177, 1505–1509 (1993).
    Article CAS Google Scholar
  3. Sypek, J.P. et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177, 1797–1802 (1993).
    Article CAS Google Scholar
  4. Scharton-Kersten, T., Alfonso, L.C., Wysocka, M., Trinchieri, G. & Scott, P. IL-12 is required for NK cell activation and subsequent Th1 cell development in experimental leishmaniasis. J. Immunol. 154, 5320–5330 (1995).
    CAS Google Scholar
  5. Locksley, R.M., Reiner, S.L., Hatam, F., Littman, D.R. & Killeen, N. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261, 1448–1451 (1993).
    Article CAS Google Scholar
  6. Launois, P., Swihart, K.G., Milon, G. & Louis, J.A. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158, 3317–3324 (1997).
    CAS PubMed Google Scholar
  7. Julia, V., Rassoulzadegan, M. & Glaichenhaus, N. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274, 421–423 (1996).
    Article CAS Google Scholar
  8. Launois, P. et al. IL-4 rapidly produced by Vβ4Vα8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6, 541– 549 (1997).
    Article CAS Google Scholar
  9. Afonso, L.C. et al. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263, 235– 237 (1994).
    Article CAS Google Scholar
  10. Mougneau, E. et al. Expression cloning of a protective Leishmania antigen. Science 268, 563–566 (1995).
    Article CAS Google Scholar
  11. Gurunathan, S. et al. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186, 1137– 1147 (1997).
    Article CAS Google Scholar
  12. Jankovic, D. et al. Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 antibody responses to HIV-1 gp120. J. Immunol. 159, 2409– 2417 (1997).
    CAS PubMed Google Scholar
  13. Campbell, K. A. et al. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 14, 283–289 (1996).
    Article Google Scholar
  14. Ma, X. et al. The IL-12 p40 gene promoter is primed by IFN-λ in monocytic cells. J. Exp. Med. 183–174 (1996).
    Article Google Scholar
  15. Ridge, J.P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474–477 ( 1998).
    Article CAS Google Scholar
  16. Bennett, S.R.M. et al. Help for cytotoxic T-cell responses is mediated by CD40 signalling. Nature 393, 478–480 (1998).
    Article CAS Google Scholar
  17. Schoenberger, S.P., Toes, R.E.M., van der Voort, E.I.H., Offringa, R. & Melief, C.J.M. T-cell help for cytotoxic T cells is mediated by CD40-CD40L interactions. Nature 393, 480–483 (1998).
    Article CAS Google Scholar
  18. Wolff, J. A., Ludtke, J.J., Acsadi, G., Williams, P. & Jani, A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363–369 (1992).
    Article CAS Google Scholar
  19. Klinman, D.M., Yi, A.K., Beaucage, S.L., Conover, J. & Krieg, A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon λ. Proc. Natl. Acad. Sci. USA 93, 2879– 2883 (1996).
    Article CAS Google Scholar
  20. Sato, Y. et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352– 354 (1996).
    Article CAS Google Scholar
  21. Zimmermann, S. et al. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160; 3627–3630 (1998).
    CAS Google Scholar
  22. Seder, R.A., Kelsall, B.L. & Jankovics, D. Differential roles of IL-12 in maintenance of immune responses in infectious vs. autoimmune disease. J. Immunol. 157, 2745–2748 (1996).
    CAS Google Scholar
  23. Hu-Li, J., Huang, H., Ryan, J. & Paul, W.E. In differentiated CD4+ T cells, interleukin-4 production is cytokine-autonomous, whereas interferon λ production is cytokine dependent. Proc. Natl. Acad. Sci. USA 94, 3189– 3194 (1997).
    Article CAS Google Scholar
  24. Murphy, E.E. et al. B7 and interleukin 12 cooperate for proliferation and interferon-λ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180, 223– 231 (1994).
    Article CAS Google Scholar
  25. Clerici, M. et al. Type 1/type 2 cytokine modulation to T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. Proc. Natl. Acad. Sci. USA 91, 11811– 11815 (1994).
    Article CAS Google Scholar
  26. Marth, T., Strober, W. & Kelsall, B.L. High dose oral tolerance in ovalbumin TCR-transgenic mice. Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157, 2348– 2357 (1996).
    CAS PubMed Google Scholar
  27. Muller, I., Pedrazzini, T., Kropf, P., Louis, J. & Milon, G. Establishment of resistance to Leishmania major infection in susceptible BALB/c mice requires parasite-specific CD8+ T cells. Int. Immunol. 3, 587–597 (1991).
    Article CAS Google Scholar
  28. Muller, I., Kropf, P., Etges, R.J. & Louis J.A. Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells. Infect. Immunol. 61, 3730–3738 (1993).
    CAS Google Scholar
  29. da Conceicao-Silva, F., Perlaza, B.L., Louis, J.A. & Romero, P. Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted CD8+ cytotoxic T cell responses. Eur. J. Immunol. 24, 2813– 2817 (1994).
    Article CAS Google Scholar
  30. Stefani, M.M., Muller, I. & Louis, J.A. _Leishmania major_-specific CD8+ T cells are inducers and targets of nitric oxide produced by parasitized macrophages. Eur. J. Immunol. 24, 746– 752 (1994).
    Article CAS Google Scholar
  31. Conceicao-Silva, F., Hahne, M., Schröter M., Louis J. & Tschopp, J. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur. J. Immunol. 28, 237–245 (1998).
    Article CAS Google Scholar
  32. Behr, M.A. & Small, P.M. Has BCG attenuated to impotence? Nature 389, 133–134 (1997).
    Article CAS Google Scholar

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