The open pore conformation of potassium channels (original) (raw)
References
del Camino, D., Holmgren, M., Liu, Y. & Yellen, G. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature403, 321–325 (2000) ArticleADSCAS Google Scholar
Liu, Y., Holmgren, M., Jurman, M. E. & Yellen, G. Gated access to the pore of a voltage-dependent K+ channel. Neuron19, 175–184 (1997) Article Google Scholar
Doyle, D. A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science280, 69–77 (1998) ArticleADSCAS Google Scholar
Zhou, Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution. Nature414, 43–48 (2001) ArticleADSCAS Google Scholar
del Camino, D. & Yellen, G. Tight steric closure at the intracellular activation gate of a voltage-gated K+ channel. Neuron32, 649–656 (2001) ArticleCAS Google Scholar
Cuello, L. G., Romero, J. G., Cortes, D. M. & Perozo, E. pH-dependent gating in the Streptomyces lividans K+ channel. Biochemistry37, 3229–3236 (1998) ArticleCAS Google Scholar
Heginbotham, L., LeMasurier, M., Kolmakova-Partensky, L. & Miller, C. Single streptomyces lividans K+ channels. Functional asymmetries and sidedness of proton activation. J. Gen. Physiol.114, 551–560 (1999) ArticleCAS Google Scholar
Perozo, E., Cortes, D. M. & Cuello, L. G. Structural rearrangements underlying K+-channel activation gating. Science285, 73–78 (1999) ArticleCAS Google Scholar
Liu, Y. S., Sompornpisut, P. & Perozo, E. Structure of the KcsA channel intracellular gate in the open state. Nature Struct. Biol.8, 883–887 (2001) ArticleCAS Google Scholar
Zhou, M., Morais-Cabral, J. H., Mann, S. & MacKinnon, R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature411, 657–661 (2001) ArticleADSCAS Google Scholar
Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature417, 515–522 (2002) ArticleADSCAS Google Scholar
Flynn, G. E., Johnson, J. P. Jr & Zagotta, W. N. Cyclic nucleotide-gated channels: shedding light on the opening of a channel pore. Nature Rev. Neurosci.2, 643–651 (2001) ArticleCAS Google Scholar
Sigworth, F. J. Voltage gating of ion channels. Q. Rev. Biophys.27, 1–40 (1994) ArticleCAS Google Scholar
Bezanilla, F. The voltage sensor in voltage-dependent ion channels. Physiol. Rev.80, 555–592 (2000) ArticleCAS Google Scholar
Jiang, Y., Pico, A., Cadene, M., Chait, B. T. & MacKinnon, R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron29, 593–601 (2001) ArticleCAS Google Scholar
Armstrong, C. M. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol.58, 413–437 (1971) ArticleCAS Google Scholar
Armstrong, C. M. Ionic pores, gates, and gating currents. Q. Rev. Biophys.7, 179–210 (1974) ArticleCAS Google Scholar
Holmgren, M., Smith, P. L. & Yellen, G. Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol.109, 527–535 (1997) ArticleCAS Google Scholar
Mitcheson, J. S., Chen, J., Lin, M., Culberson, C. & Sanguinetti, M. C. A structural basis for drug-induced long QT syndrome. Proc. Natl Acad. Sci. USA97, 12329–12333 (2000) ArticleADSCAS Google Scholar
Roux, B. & MacKinnon, R. The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations. Science285, 100–102 (1999) ArticleCAS Google Scholar
Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science250, 533–538 (1990) ArticleADSCAS Google Scholar
Zagotta, W. N., Hoshi, T. & Aldrich, R. W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science250, 568–571 (1990) ArticleADSCAS Google Scholar
Bezanilla, F. & Armstrong, C. M. Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol.70, 549–566 (1977) ArticleCAS Google Scholar
Armstrong, C. M. & Bezanilla, F. Inactivation of the sodium channel. II. Gating current experiments. J. Gen. Physiol.70, 567–590 (1977) ArticleCAS Google Scholar
Rettig, J. et al. Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit. Nature369, 289–294 (1994) ArticleADSCAS Google Scholar
Warwicker, J. & Watson, H. C. Calculation of the electric potential in the active site cleft due to alpha-helix dipoles. J. Mol. Biol.157, 671–679 (1982) ArticleCAS Google Scholar
Klapper, I., Hagstrom, R., Fine, R., Sharp, K. & Honig, B. Focusing of electric fields in the active site of Cu-Zn superoxide dismutase: effects of ionic strength and amino-acid modification. Proteins1, 47–59 (1986) ArticleCAS Google Scholar
Esnouf, R. M. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. Model.15, 132–133 (1997) ArticleCAS Google Scholar
Nicholls, A., Sharp, K. A. & Honig, B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins11, 281–296 (1991) ArticleCAS Google Scholar