The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells (original) (raw)
References
Fuller, G.N. in Pediatric Neoplasia: Morphology and Biology (ed. David M. Parham) 153–204 (Lippincott-Ravel, Philadelphia, 1996). Google Scholar
Provias, J.P., and Becker, L. E. Cellular and molecular pathology of medulloblastoma. J. Neurooncol.29, 35 –43 (1996). ArticleCAS Google Scholar
He, X.M. et al. Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. J. Neuropathol. Exp. Neurol.48, 48–68 (1989). ArticleCAS Google Scholar
Whelan, H.T., Krouwer, H.G., Schmidt, M.H., Reichert, K.W. & Kovnar, E.H. Current therapy and new perspectives in the treatment of medulloblastoma. Pediatr. Neurol.18, 103–115 (1998). ArticleCAS Google Scholar
Goussia, A.C., Bruner, J.M., Kyritsis, A.P., Agnantis, N.K. & Fuller, G.N. Cytogenetic and molecular genetic abnormalities in primitive neuroectodermal tumors of the central nervous system . Anticancer Res.20, 65– 74 (2000). CASPubMed Google Scholar
Adesina, A.M., Nalbantoglu, J. & Cavenee, W.K. p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res.54, 5649–5651 (1994). CASPubMed Google Scholar
Chong, J.A. et al. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell80, 949 –957 (1995). ArticleCAS Google Scholar
Schoenherr, C.J. & Anderson, D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science267, 1360– 1363 (1995). ArticleCAS Google Scholar
Schoenherr, C.J., Paquette, A.J. & Anderson, D.J. Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl. Acad. Sci. USA93, 9881–9886 (1996). ArticleCAS Google Scholar
Tapia-Ramirez, J., Eggen, B.J., Peral-Rubio, M.J., Toledo-Aral, J.J. & Mandel, G. A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter. Proc. Natl. Acad. Sci. USA94, 1177–1182 (1997). ArticleCAS Google Scholar
Tohyama, T. et al. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab. Invest.66, 303–313 (1992). CASPubMed Google Scholar
Andres, M.E. et al. CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl. Acad. Sci. USA96, 9873–9878 (1999). ArticleCAS Google Scholar
Huang, Y., Meyers, S.J. & Dingledine . Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nature Neurosci.2, 867 –872 (1999). ArticleCAS Google Scholar
Grimes, J.A. et al. The co-repressor mSin3A is a functional component of the REST–CoREST repressor complex. J. Biol. Chem.31, 9461 –9467 (2000). Article Google Scholar
Majumder, S., Zhao, Z., Kaneko, K. & DePamphilis, M.L. Developmental acquisition of enhancer function requires a unique coactivator activity. EMBO J.16, 1721–1731 ( 1997). ArticleCAS Google Scholar
Chen, Z.F., Paquette, A.J. & Anderson, D.J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nature Genet.20, 136–142 ( 1998). ArticleCAS Google Scholar
Jacobsen, P.F., Jenkyn, D.J. & Papadimitriou, J.M. Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice. J. Neuropathol. Exp. Neurol.44, 472–485 ( 1985). ArticleCAS Google Scholar
Hollstein M., Sidransky, D., Vogelstein, B. & Harris, C.C. p53 mutations in human cancers. Science253, 49–53 (1991). ArticleCAS Google Scholar
Harris, C.C. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J. Natl. Cancer Inst.88, 1442–1455 (1996) ArticleCAS Google Scholar
Raffel, C., Thomas, G.A., Tishler, D.M., Lassoff, S. & Allen, J.C. Absence of p53 mutations in childhood central nervous system primitive neuroectodermal tumors. Neurosurgery33, 301–306 ( 1993). ArticleCAS Google Scholar
Xie, J. et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res.57, 2369– 2372 (1997). CASPubMed Google Scholar
Goodrich, L.V., Milenkovic, L., Higgins, K.M. & Scott, M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science277, 1109–1113 ( 1997). ArticleCAS Google Scholar
Perrimon, N. & McMahon, A.P. Negative feedback mechanisms and their roles during pattern formation. Cell97, 13–16 (1999). ArticleCAS Google Scholar
McMahon, A.P. More surprises in the hedgehog signaling pathway. Cell100, 185–188 (2000). ArticleCAS Google Scholar