FTO genotype is associated with phenotypic variability of body mass index (original) (raw)

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Acknowledgements

We acknowledge funding from the Australian National Health and Medical Research Council (NHMRC grants 241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485, 613672, 613601 and 1011506), the US National Institutes of Health (grants AA07535, AA10248, AA014041, AA13320, AA13321, AA13326, DA12854 and GM057091) and the Australian Research Council (ARC grant DP1093502). A detailed list of acknowledgements by study is provided in the Supplementary Information. We apologize to authors whose work we could not cite owing to space restrictions.

Author information

Author notes

1. Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Authors and Affiliations

1. University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.,
   Jian Yang, Joseph E. Powell & Peter M. Visscher
2. Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.,
   Jian Yang, Joseph E. Powell, Sarah E. Medland, Dale R. Nyholt, Grant W. Montgomery, Nicholas G. Martin & Peter M. Visscher
3. MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.,
   Ruth J. F. Loos, Jing Hua Zhao, Jian’an Luan & Nicholas J. Wareham
4. Mount Sinai School of Medicine, New York, 10029, New York, USA
   Ruth J. F. Loos
5. Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.,
   Elizabeth K. Speliotes
6. Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.,
   Elizabeth K. Speliotes
7. Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue, Boston, Massachusetts 02215, USA.,
   Daniel I. Chasman, Lynda M. Rose & Paul M. Ridker
8. Harvard Medical School, Boston, 02215, Massachusetts, USA
   Daniel I. Chasman & Paul M. Ridker
9. deCODE genetics, IS-101 Reykjavik, Iceland.,
   Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Unnur Thorsteinsdottir & Kari Stefansson
10. Estonian Genome Center, University of Tartu, Tartu 50410, Estonia.,
    Reedik Mägi, Tõnu Esko, Krista Fischer & Andres Metspalu
11. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.,
    Reedik Mägi, Anubha Mahajan, Anuj Goel, Inga Prokopenko, Cecilia M. Lindgren, Hugh Watkins & Mark I. McCarthy
12. Hudson Alpha Institute for Biotechnology, Huntsville, 35806, Alabama, USA
    Lindsay Waite
13. Icelandic Heart Association, IS-201 Kopavogur, Iceland.,
    Albert Vernon Smith & Vilmundur Gudnason
14. University of Iceland, IS-101 Reykjavik, Iceland.,
    Albert Vernon Smith & Vilmundur Gudnason
15. Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA
    Laura M. Yerges-Armstrong, Alan R. Shuldiner & Jeffrey R. O’Connell
16. Department of Epidemiology, The University of North Carolina, Chapel Hill, 27514, North Carolina, USA
    Keri L. Monda
17. Division of Population Health Sciences & Education, St George’s, University of London, London SW17 0RE, UK.,
    David Hadley & David P. Strachan
18. Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.,
    Guo Li
19. Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland.,
    Karen Kapur, Zoltán Kutalik & Jacques S. Beckmann
20. Swiss Institute of Bioinformatics, 1005 Lausanne, Switzerland.,
    Karen Kapur & Zoltán Kutalik
21. MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK.,
    Veronique Vitart, Jennifer E. Huffman, Caroline Hayward & Alan F. Wright
22. Department of Genetics, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Sophie R. Wang & Joel N. Hirschhorn
23. Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA.,
    Sophie R. Wang, Cameron Palmer & Joel N. Hirschhorn
24. Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.,
    Sophie R. Wang, Cameron Palmer & Joel N. Hirschhorn
25. Department of Epidemiology, Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.,
    Ayşe Demirkan, Aaron Isaacs, Ben A. Oostra & Cornelia M. van Duijn
26. Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.,
    Mary F. Feitosa, Ingrid B. Borecki & Michael A. Province
27. Boston University, Boston, 02118, Massachusetts, USA
    Nancy L. Heard-Costa, Charles White, L. Adrienne Cupples & Larry D. Atwood
28. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.,
    Anne U. Jackson & Michael Boehnke
29. Universität zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lübeck, Germany.,
    Michael Preuss, Jeanette Erdmann & Heribert Schunkert
30. Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, 23562 Lübeck, Germany.,
    Michael Preuss & Andreas Ziegler
31. Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.,
    Joel Eriksson, Mattias Lorentzon & Claes Ohlsson
32. Department of Health Sciences, University of Milano, 20133 Milano, Italy.,
    Francesca Frau & Daniele Cusi
33. Department of Epidemiology, Unit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.,
    Ilja M. Nolte & Harold Snieder
34. Department of Endocrinology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.,
    Jana V. Van Vliet-Ostaptchouk & Melanie M. Van der Klauw
35. LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.,
    Jana V. Van Vliet-Ostaptchouk, Melanie M. Van der Klauw & Harold Snieder
36. Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands.,
    Jouke-Jan Hottenga, Gonneke Willemsen, Jacqueline M. Vink, Eco J. C. de Geus & Dorret I. Boomsma
37. Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.,
    Kevin B. Jacobs
38. Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.,
    Niek Verweij & Pim van der Harst
39. Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK.,
    Anuj Goel & Hugh Watkins
40. Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, The Netherlands.,
    Carolina Medina-Gomez, Karol Estrada, M. Carola Zillikens, André G. Uitterlinden, Fernando Rivadeneira & M. Carola Zillikens
41. Department of Epidemiology, Erasmus MC, Rotterdam 3015GE, The Netherlands.,
    Carolina Medina-Gomez, Karol Estrada, Albert Hofman, Jacqueline C. Witteman, André G. Uitterlinden & Fernando Rivadeneira
42. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.,
    Carolina Medina-Gomez, Karol Estrada, Albert Hofman, Jacqueline C. Witteman, André G. Uitterlinden & Fernando Rivadeneira
43. Biostatistics - Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.,
    Jennifer Lynn Bragg-Gresham, Carlo Sidore & Goncalo R. Abecasis
44. Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy.,
    Serena Sanna
45. Dipartimento di Scienze Biomediche, Università di Sassari, 07100 SS, Italy.,
    Carlo Sidore
46. Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.,
    Jonathan Tyrer
47. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17487 Greifswald, Germany.,
    Alexander Teumer & Georg Homuth
48. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7BN, UK.,
    Inga Prokopenko & Mark I. McCarthy
49. Department of Twin Research and Genetic Epidemiology, King’s College London, Lambeth Palace Road, London SE1 7EH, UK.,
    Massimo Mangino & Tim D. Spector
50. Department of Medicine, Stanford University School of Medicine, Stanford 94305, California, USA.,
    Themistocles L. Assimes
51. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA.,
    Alan R. Shuldiner
52. Pathology and Laboratory Medicine, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Jennie Hui & John P. Beilby
53. Molecular Genetics, PathWest Laboratory Medicine WA, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Jennie Hui & John P. Beilby
54. School of Population Health, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Jennie Hui
55. School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.,
    Wendy L. McArdle
56. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.,
    Per Hall, Henrik Grönberg & Erik Ingelsson
57. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.,
    Talin Haritunians
58. Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.,
    Lina Zgaga, Sarah H. Wild, Igor Rudan, James F. Wilson & Harry Campbell
59. Andrija Stampar School of Public Health, Medical School University of Zagreb, Zagreb, Croatia
    Lina Zgaga
60. Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.,
    Ivana Kolcic, Ozren Polasek, Tatijana Zemunik & Igor Rudan
61. Department Of Internal Medicine, Institute of Clinical Medicine, University of Oulu, 90014 Oulu, Finland.,
    M. Juhani Junttila & Heikki V. Huikuri
62. Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, 24098 Kiel, Germany.,
    Stefan Schreiber
63. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.,
    Annette Peters
64. Munich Heart Alliance, 80802 Munich, Germany.,
    Annette Peters
65. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.,
    Andrew A. Hicks
66. Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.,
    Jonathan Stephens, Nicola S. Foad & Jennifer D. Jolley
67. NHS Blood and Transplant, Cambridge, Cambridge CB2 0PT, UK.,
    Jonathan Stephens, Nicola S. Foad & Jennifer D. Jolley
68. Finnish Institute of Occupational Health, 90220 Oulu, Finland.,
    Jaana Laitinen
69. National Institute for Health and Welfare, 90101 Oulu, Finland.,
    Anneli Pouta & Marjo-Riitta Jarvelin
70. Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland.,
    Anneli Pouta
71. Institute of Health Sciences, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.,
    Marika Kaakinen & Marjo-Riitta Jarvelin
72. Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.,
    Gerjan Navis
73. Department of Cardiology, Division Heart & Lungs, University medical Center Utrecht, 3508 GA Utrecht, The Netherlands.,
    Folkert W. Asselbergs
74. Institute of Epidemiology and Social Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.,
    Ulrich John
75. Division of Research, Kaiser Permanente Northern California, Oakland, 94612, California, USA
    Carlos Iribarren
76. National Institutes on Aging, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Tamara Harris & Lenore Launer
77. Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Centers, Houston, 77030, Texas, USA
    Eric Boerwinkle
78. Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.,
    Gemma Cadby & Lyle J. Palmer
79. Medicine and Pharmacology, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Alan L. James & Arthur W. Musk
80. Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Alan L. James
81. Respiratory Medicine, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia.,
    Arthur W. Musk
82. Departments of Medicine, Cardiovascular Health Research Unit, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101, USA.,
    Bruce M. Psaty
83. Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.,
    Bruce M. Psaty
84. Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland.,
    Jacques S. Beckmann
85. Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland.,
    Gerard Waeber & Peter Vollenweider
86. Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, 20502 Malmö, Sweden.,
    Leif C. Groop
87. Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.,
    Kay-Tee Khaw
88. Département de Médecine, Université de Montréal, Montréal, Québec H4J 1C5, Canada.,
    Jean-Claude Tardif & Guillaume Lettre
89. Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada.,
    Jean-Claude Tardif & Guillaume Lettre
90. Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA.,
    L. Adrienne Cupples, Caroline S. Fox & Sekar Kathiresan
91. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.,
    Francis S. Collins
92. Department of Genetics, University of North Carolina, Chapel Hill, 27599-7264, North Carolina, USA
    Karen L. Mohlke
93. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universität zu Lübeck, 23562 Lübeck, Germany.,
    Jeanette Erdmann & Heribert Schunkert
94. Klinik und Poliklinik für Innere Medizin II, 93053 Regensburg, Germany.,
    Christian Hengstenberg & Klaus Stark
95. Department of Cardiovascular Diseases, University of Leuven, 3000 Leuven, Belgium.,
    Jan A. Staessen
96. Department of Epidemiology, Maastricht University, 6200 MD Maastricht, The Netherlands.,
    Jan A. Staessen
97. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.,
    Peter P. Pramstaller
98. Department of Neurology, General Central Hospital, 39100 Bolzano, Italy.,
    Peter P. Pramstaller
99. Department of Neurology, University of Lübeck, 23562 Lübeck, Germany.,
    Peter P. Pramstaller
100. Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.,
     Sekar Kathiresan
101. Center for Human Genetics Research, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
     Sekar Kathiresan
102. Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
     Sekar Kathiresan
103. Department of Medicine, Harvard Medical School, Boston, 02115, Massachusetts, USA
     Sekar Kathiresan
104. Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland.,
     Samuli Ripatti
105. Public Health Genomics Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.,
     Samuli Ripatti
106. Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.,
     Samuli Ripatti
107. Department of Epidemiology and Biostatistics, MRC-HPA Center for Environment and Health, Imperial College London, London W2 1PG, UK.,
     Marjo-Riitta Jarvelin
108. Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.,
     Brenda Penninx
109. Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA.,
     Stephen J. Chanock & Sonja I. Berndt
110. Karolinska Institutet, 171 77 Stockholm, Sweden.,
     Anders Hamsten
111. Department of Medicine, Atherosclerosis Research Unit, Solna, 171 76 Stockholm, Sweden.,
     Anders Hamsten
112. Epidemiology, Biostatistics & HTA, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.,
     Lambertus A. Kiemeney & Sita H. Vermeulen
113. National Institute on Aging, National Institutes of Health, Bethesda, 20892, Maryland, USA
     David Schlessinger
114. Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.,
     Sabine Schipf
115. Department of Medicine, University of Leipzig, 04103 Leipzig, Germany.,
     Michael Stumvoll & Anke Tönjes
116. IFB Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany.,
     Michael Stumvoll & Anke Tönjes
117. Department of Epidemiology and Carolina Center for Genome Sciences, The University of North Carolina, Chapel Hill, North Carolina 27514, USA.,
     Kari E. North
118. Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford OX3 7LJ, UK.,
     Mark I. McCarthy
119. Department of Psychiatry, Washington University St Louis, 63110, Missouri, USA
     Andrew C. Heath & Pamela A. F. Madden
120. Department of Biostatistics, University of Washington, Seattle, 98115, Washington, USA
     Barbara McKnight
121. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.,
     William G. Hill
122. Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.,
     Unnur Thorsteinsdottir & Kari Stefansson
123. Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter EX1 2LU, UK.,
     Timothy M. Frayling
124. Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia.,
     Michael E. Goddard
125. Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria 3083, Australia.,
     Michael E. Goddard
126. Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Queensland, Australia
     Peter M. Visscher

Authors

1. Jian Yang
2. Ruth J. F. Loos
3. Joseph E. Powell
4. Sarah E. Medland
5. Elizabeth K. Speliotes
6. Daniel I. Chasman
7. Lynda M. Rose
8. Gudmar Thorleifsson
9. Valgerdur Steinthorsdottir
10. Reedik Mägi
11. Lindsay Waite
12. Albert Vernon Smith
13. Laura M. Yerges-Armstrong
14. Keri L. Monda
15. David Hadley
16. Anubha Mahajan
17. Guo Li
18. Karen Kapur
19. Veronique Vitart
20. Jennifer E. Huffman
21. Sophie R. Wang
22. Cameron Palmer
23. Tõnu Esko
24. Krista Fischer
25. Jing Hua Zhao
26. Ayşe Demirkan
27. Aaron Isaacs
28. Mary F. Feitosa
29. Jian’an Luan
30. Nancy L. Heard-Costa
31. Charles White
32. Anne U. Jackson
33. Michael Preuss
34. Andreas Ziegler
35. Joel Eriksson
36. Zoltán Kutalik
37. Francesca Frau
38. Ilja M. Nolte
39. Jana V. Van Vliet-Ostaptchouk
40. Jouke-Jan Hottenga
41. Kevin B. Jacobs
42. Niek Verweij
43. Anuj Goel
44. Carolina Medina-Gomez
45. Karol Estrada
46. Jennifer Lynn Bragg-Gresham
47. Serena Sanna
48. Carlo Sidore
49. Jonathan Tyrer
50. Alexander Teumer
51. Inga Prokopenko
52. Massimo Mangino
53. Cecilia M. Lindgren
54. Themistocles L. Assimes
55. Alan R. Shuldiner
56. Jennie Hui
57. John P. Beilby
58. Wendy L. McArdle
59. Per Hall
60. Talin Haritunians
61. Lina Zgaga
62. Ivana Kolcic
63. Ozren Polasek
64. Tatijana Zemunik
65. Ben A. Oostra
66. M. Juhani Junttila
67. Henrik Grönberg
68. Stefan Schreiber
69. Annette Peters
70. Andrew A. Hicks
71. Jonathan Stephens
72. Nicola S. Foad
73. Jaana Laitinen
74. Anneli Pouta
75. Marika Kaakinen
76. Gonneke Willemsen
77. Jacqueline M. Vink
78. Sarah H. Wild
79. Gerjan Navis
80. Folkert W. Asselbergs
81. Georg Homuth
82. Ulrich John
83. Carlos Iribarren
84. Tamara Harris
85. Lenore Launer
86. Vilmundur Gudnason
87. Jeffrey R. O’Connell
88. Eric Boerwinkle
89. Gemma Cadby
90. Lyle J. Palmer
91. Alan L. James
92. Arthur W. Musk
93. Erik Ingelsson
94. Bruce M. Psaty
95. Jacques S. Beckmann
96. Gerard Waeber
97. Peter Vollenweider
98. Caroline Hayward
99. Alan F. Wright
100. Igor Rudan
101. Leif C. Groop
102. Andres Metspalu
103. Kay-Tee Khaw
104. Cornelia M. van Duijn
105. Ingrid B. Borecki
106. Michael A. Province
107. Nicholas J. Wareham
108. Jean-Claude Tardif
109. Heikki V. Huikuri
110. L. Adrienne Cupples
111. Larry D. Atwood
112. Caroline S. Fox
113. Michael Boehnke
114. Francis S. Collins
115. Karen L. Mohlke
116. Jeanette Erdmann
117. Heribert Schunkert
118. Christian Hengstenberg
119. Klaus Stark
120. Mattias Lorentzon
121. Claes Ohlsson
122. Daniele Cusi
123. Jan A. Staessen
124. Melanie M. Van der Klauw
125. Peter P. Pramstaller
126. Sekar Kathiresan
127. Jennifer D. Jolley
128. Samuli Ripatti
129. Marjo-Riitta Jarvelin
130. Eco J. C. de Geus
131. Dorret I. Boomsma
132. Brenda Penninx
133. James F. Wilson
134. Harry Campbell
135. Stephen J. Chanock
136. Pim van der Harst
137. Anders Hamsten
138. Hugh Watkins
139. Albert Hofman
140. Jacqueline C. Witteman
141. M. Carola Zillikens
142. André G. Uitterlinden
143. Fernando Rivadeneira
144. M. Carola Zillikens
145. Lambertus A. Kiemeney
146. Sita H. Vermeulen
147. Goncalo R. Abecasis
148. David Schlessinger
149. Sabine Schipf
150. Michael Stumvoll
151. Anke Tönjes
152. Tim D. Spector
153. Kari E. North
154. Guillaume Lettre
155. Mark I. McCarthy
156. Sonja I. Berndt
157. Andrew C. Heath
158. Pamela A. F. Madden
159. Dale R. Nyholt
160. Grant W. Montgomery
161. Nicholas G. Martin
162. Barbara McKnight
163. David P. Strachan
164. William G. Hill
165. Harold Snieder
166. Paul M. Ridker
167. Unnur Thorsteinsdottir
168. Kari Stefansson
169. Timothy M. Frayling
170. Joel N. Hirschhorn
171. Michael E. Goddard
172. Peter M. Visscher

Contributions

P.M.V., M.E.G. and J.Y. conceived and designed the study. J.Y. and P.M.V. derived the analytical theory. J.Y. performed the meta-analyses and simulations. J.Y. and P.M.V. wrote the first draft of the manuscript. J.Y., D.I.C., J.H.Z. and R.J.F.L. performed further statistical verification analyses. D.P.S., W.G.H., R.J.F.L., S.I.B. and H. Snieder contributed important additional concepts and critically reviewed the manuscript before submission. S.E.M., P.A.F.M., A.C.H., N.G.M., D.R.N. and G.W.M. contributed the individual-level genotype and phenotype data of the QIMR cohort. T.M.F., J.N.H. and R.J.F.L. liaised with the GIANT consortium for this project. The cohort-specific contributions of all other authors are provided in the Supplementary Information.

Corresponding author

Correspondence toPeter M. Visscher.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Information

This file contains Supplementary Figures 1-10, Supplementary Tables 1-5, Supplementary Notes and Data, Supplementary References, Supplementary Acknowledgements (study-specific) and Supplementary Author Contributions. Supplementary Tables 4, 5 and the Acknowledgements were corrected on 31 January 2013. (PDF 1652 kb)

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Yang, J., Loos, R., Powell, J. et al. FTO genotype is associated with phenotypic variability of body mass index.Nature 490, 267–272 (2012). https://doi.org/10.1038/nature11401

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• Received: 15 January 2012
• Accepted: 06 July 2012
• Published: 16 September 2012
• Issue date: 11 October 2012
• DOI: https://doi.org/10.1038/nature11401