Tumorigenesis: Twist1 links EMT to self-renewal (original) (raw)

Nature Cell Biology volume 12, pages 924–925 (2010)Cite this article

Subjects

The epithelial–mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Molecular links are beginning to emerge between hypoxia, EMT and stemness.

References

  1. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Nature 414, 105–111 (2001).
    Article CAS Google Scholar
  2. Gupta, H., Chaffer, C. L. & Weinberg, R. A. Nat. Med. 9, 1010–1012 (2009).
    Article Google Scholar
  3. Thiery J. P., Acloque H., Huang R. Y. & Nieto M. A. Cell 139, 871–890 (2009).
    Article CAS Google Scholar
  4. Mani, S. A. et al. Cell 133, 704–715 (2008).
    Article CAS Google Scholar
  5. Morel, A. P. et al. PLoS One 3, e2888 (2008).
    Article Google Scholar
  6. Wellner. et al. Nat. Cell Biol. 11, 1487–1495 (2009).
    Article CAS Google Scholar
  7. Yang, M. -H. et al. Nat. Cell Biol. 12, 982–992 (2010).
    Article Google Scholar
  8. Yang, M. -H. et al. Nat. Cell Biol. 10, 295–305 (2008).
    Article CAS Google Scholar
  9. Park, I.-K., Morrison, S. J. & Clarke, M. F. J. Clin. Invest. 113, 175–179 (2004).
    Article CAS Google Scholar
  10. Jacobs, J. J. et al. Nature 397, 164–168 (1999).
    Article CAS Google Scholar
  11. Cano, A & Nieto, M. A. Trends Cell Biol. 18, 357–359 (2008).
    Article CAS Google Scholar
  12. Brabletz, T. et al. Nat. Rev. Cancer 5, 744–749 (2005).
    Article CAS Google Scholar
  13. Li, R. et al. Cell Stem Cell 7, 51–63 (2010).
    Article CAS Google Scholar
  14. Samavarchi-Tehrani, P. et al. Cell Stem Cell 7, 64–77 (2010).
    Article CAS Google Scholar
  15. Ocaña, O. H. & Nieto, M. A. Cell Research doi: 10.1038/cr.2010.127 (in the press).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Alberto Martin and Amparo Cano are in the Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, IdiPAZ, Arzobispo Morcillo, 2, 28029 Madrid, Spain and the Instituto de Investigaciones Biomédicas “Alberto Sols” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Arzobispo Morcillo, 2, 28029 Madrid, Spain.,
    Alberto Martin & Amparo Cano

Authors

  1. Alberto Martin
  2. Amparo Cano

Corresponding author

Correspondence toAmparo Cano.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

About this article

Cite this article

Martin, A., Cano, A. Tumorigenesis: Twist1 links EMT to self-renewal.Nat Cell Biol 12, 924–925 (2010). https://doi.org/10.1038/ncb1010-924

Download citation

This article is cited by